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2000
Volume 19, Issue 6
  • ISSN: 1570-193X
  • E-ISSN: 1875-6298

Abstract

5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure 9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine- 2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a 98% yield. Biological evaluations of various prepared derivatives by various researchers were described.

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/content/journals/mroc/10.2174/1570193X19666220110121158
2022-09-01
2025-10-20
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