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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Novel Synthesis of p-Nitrobenzylphosphonic Acid and its Action on Alkaline Phosphatase
- Source: Letters in Organic Chemistry, Volume 5, Issue 7, Oct 2008, p. 563 - 565
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- 01 Oct 2008
Abstract
p-Nitrobenzylphosphonic acid was obtained via a nucleophilic substitution of nitrobenzyl bromide with trimethyl phosphite as opposed to nitration of benzylphosphonic acid. This compound is a competitive inhibitor of alkaline phosphatase (KI ∼ 125 μM) and has potential to inhibit a wide range of other phosphatases including serine/threonine phosphatases and tyrosine phosphatases.
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