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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3- Catalysed Three-Component aza Diels-Alder Reaction
- Source: Letters in Organic Chemistry, Volume 5, Issue 7, Oct 2008, p. 559 - 562
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- 01 Oct 2008
Abstract
The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen- 2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties.
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