Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Jose C. Barros; Joaquim F. M. da Silva; Alexandre R. Calazans; Amilcar Tanuri; Rodrigo de Morais Brindeiro; John S. Williamson; Octavio A.C. Antunes

doi:10.2174/157017806779468040

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease
Authors: Jose C. Barros¹, Joaquim F. M. da Silva², Alexandre R. Calazans³, Amilcar Tanuri⁴, Rodrigo de Morais Brindeiro⁵, John S. Williamson⁶ and Octavio A.C. Antunes⁷
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¹ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ² Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ³ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ⁴ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ⁵ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ⁶ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil. ⁷ Instituto de Quimica, Universidade Federal do Rio de Janeiro, 21944-910, Rio de Janeiro, Brazil.
Source: Letters in Organic Chemistry, Volume 3, Issue 12, Dec 2006, p. 882 - 886
DOI: https://doi.org/10.2174/157017806779468040
- Available online: 01 Dec 2006

Abstract

New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1' and P2/P2' subsites of the enzyme. The products were obtained in good yields without noticeable racemization.

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2006-12-01

2025-09-09

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Article Type: Research Article

Keyword(s): AIDS; C2 symmetry; HIV; protease inhibitors; pseudopeptides; tartaric acid

Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Abstract

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