Synthesis and Functionalization of 6,7-Dihydro-[1,4]Dioxino[2,3-d] Pyrimidines

Guido Lavecchia; Sabine Berteina-Raboin; Gerald Guillaumet

doi:10.2174/157017806779468031

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis and Functionalization of 6,7-Dihydro-[1,4]Dioxino[2,3-d] Pyrimidines
Authors: Guido Lavecchia¹, Sabine Berteina-Raboin² and Gerald Guillaumet³
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¹ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d'Orleans, BP 6759, 45067 Orleans Cedex 2, France. ² Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d'Orleans, BP 6759, 45067 Orleans Cedex 2, France. ³ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d'Orleans, BP 6759, 45067 Orleans Cedex 2, France.
Source: Letters in Organic Chemistry, Volume 3, Issue 12, Dec 2006, p. 877 - 881
DOI: https://doi.org/10.2174/157017806779468031
- Available online: 01 Dec 2006

Abstract

The cyclization of 4,5-dihydroxy-2-methyl-pyrimidine followed by dibromination and oxidation of the methyl group led to 6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidine-2-carboxaldehyde. This compound underwent different chemical transformations on carbonyl group to synthesize various 2-substituted-6,7- dihydro-[1,4]dioxino[2,3-d]pyrimidines.

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2006-12-01

2025-09-09

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Article Type: Research Article

Keyword(s): 2-dibromomethyl-DDP; modified Harris synthesis; N-alkylation; quantitative deprotection; Wittig reaction

Synthesis and Functionalization of 6,7-Dihydro-[1,4]Dioxino[2,3-d] Pyrimidines

Abstract

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