Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

E. Kerouredan; M. Prakesch; D. Gree; R. Gree

doi:10.2174/1570178043488662

ISSN: 1570-1786
E-ISSN: 1875-6255

Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE
Authors: E. Kerouredan¹, M. Prakesch², D. Gree³ and R. Gree⁴
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¹ ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, CNRS UMR 6052, Avenue du General Leclerc, 35700 Rennes Beaulieu, France. ² ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, CNRS UMR 6052, Avenue du General Leclerc, 35700 Rennes Beaulieu, France. ³ ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, CNRS UMR 6052, Avenue du General Leclerc, 35700 Rennes Beaulieu, France. ⁴ ENSCR, Laboratoire de Syntheses et Activations de Biomolecules, CNRS UMR 6052, Avenue du General Leclerc, 35700 Rennes Beaulieu, France.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 78 - 80
DOI: https://doi.org/10.2174/1570178043488662
- Available online: 01 Jan 2004

Abstract

The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below.

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2004-01-01

2025-10-03

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Article Type: Review Article

Keyword(s): 13 hode; dast; fluorine; lipids

Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

Abstract

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