Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity

Y. N. Belokon; P. Carta; M. North

doi:10.2174/1570178043488617

ISSN: 1570-1786
E-ISSN: 1875-6255

Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity
Authors: Y. N. Belokon¹, P. Carta² and M. North³
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¹ Department of Chemistry, King's College London, Strand, London, WC2R 2LS, UK. ² Department of Chemistry, King's College London, Strand, London, WC2R 2LS, UK. ³ Department of Chemistry, King's College London, Strand, London, WC2R 2LS, UK.
Source: Letters in Organic Chemistry, Volume 1, Issue 1, Jan 2004, p. 81 - 83
DOI: https://doi.org/10.2174/1570178043488617
- Available online: 01 Jan 2004

Abstract

A bimetallic titanium(salen) complex has been shown to catalyse the asymmetric addition of potassium cyanide to aldehydes in the presence of a range of anhydrides, leading to cyanohydrin esters. Linear aliphatic anhydrides (acetic and propionic) gave products with higher enantiomeric purity than those obtained using pivalic or benzoic anhydrides.

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2004-01-01

2025-10-03

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Article Type: Review Article

Keyword(s): catalyst; cyanohydrin; ester; salen; titanium

Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity

Abstract

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