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2000
Volume 22, Issue 9
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In this work, novel bis(benzimidazole)amine, -benzimidazole(benzothiazole)amine, and benzimidazole(benzoxazole)amine have been synthesized a one-pot, intramolecular cyclization of 2-iodoaniline and 2-aminobenzimidazoles (thiazoles and oxazoles)-trichloroacetonitrile adduct using copper(I) iodide and DMF under ultrasound-assisted reaction with moderate to good yields. Using basic materials and simple and available reagents, gentle copper-catalyzed reaction conditions, easy purification with the help of solvent, good yields, non-addition of ligands, application of a simple and efficient sonochemical method, short reaction times, and the synthesis of 15 new heterocycle compounds have been appreciable features of this protocol.

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2025-02-17
2025-09-08

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Synthesis of Novel Substituted Bis(benzimidazole)amine, N-Benzimidazole(benzothiazole)amine, and N Benzimidazole(benzoxazole)amine Under Ultrasound Irradiation via Copper-Catalyzed Reaction
Lett. Org. Chem. 22, 730 (2025); https://doi.org/10.2174/0115701786365139250130094121
/content/journals/loc/10.2174/0115701786365139250130094121
/content/journals/loc/10.2174/0115701786365139250130094121
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  • Article Type:     Research Article
Keyword(s): 2-iodoaniline; bis(benzimidazole)amine; copper-catalyzed; N-benzimidazole(benzothiazole)amine; N-benzimidazole(benzoxazole)amine; trichloroacetonitrile; ullmann coupling; Ultrasound-assisted

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