Drug Delivery Letters - Volume 7, Issue 1, 2017

The design and fabrication of transdermal system is an art. Out of many transdermal systems, the introduction of Drug-in-adhesive drug delivery executes close contact of the carrier with stratum corneum to deliver active molecules across the skin and then into the systemic circulation. Thus, aspect of adhesives in transdermal is vital parameter for fabrication design with respect to safety, efficacy and quality of transdermal dr Read More

Objective: To formulate pH-sensitive spray dried microspheres loaded with an anti-cancer drug, capecitabine, using hydrolyzed polyacrylamide-grafted-acacia gum (PAAm-g-AG) for colon targeted delivery. Methods: The pH-sensitive PAAm-g-AG was synthesized by free radical polymerization and allowed for alkaline hydrolysis. Results: The obtained microspheres were sphere-shaped and drug encapsulation efficiency was foun Read More

Objective: The aim of this study was to develop and evaluate self microemulsifying drug delivery system (SMEDDS) to improve oral bioavailability of tacrolimus. Methods: The solubility of tacrolimus in various oils, surfactants and co-surfactants was determined and self-microemulsion preconcentrates were prepared. Pseudo-ternary phase diagrams were constructed to identify stable microemulsion region. The prepare Read More

Background and Objective: Nanoparticles (NPs) have been recognized as important drug delivery agents in several instances including the delivery of antibiotics against intracellular pathogenic microorganisms. In this work the activity of self-assembled nanoparticles (NPs) of clarithromycin (CLA), cationic lipid and polyelectrolytes against important mycobacteria such as Mycobacterium abscessus is evaluated. Methods: NPs f Read More

Context: Nitrendipine is a model drug which is widely used to treat hypertension. It has very low solubility in water so, it has been formulated in various dosage forms to improve the dissolution. Further, it has high first pass metabolism and bioavailability is very less. Objective: The present study gives the preparation and characterization of nitrendipine nanoliposome for controlled delivery. Materials & Methods: The vesicles Read More

Background and Objective: Meclizine (MCZ) is a Biopharmaceutical Classification System (BCS) class-II drug, which is a poorly water-soluble drug along-with very slow-onset of action. In this study MCZ was complexed with different cyclodextrins (CDs), like, sodium sulfobutylether β-CD (SBEβCD), hydroxypropyl β-CD, randomly methylated β-CD, and methyl β-CD, to enhance its solubility for repurposing of this drug for th Read More

Background and Objective: The 4T1 murine breast cancer cell line is commonly employed to study breast cancer metastasis. Transfections to this cell line are frequently carried out using lipid/polymer based gene delivery vehicles. The research paper attempts to use peptide based transfecting agents Str-R8 and MTS-AR8 for in vitro transfection of 4T1 cells. Methods: These peptides were investigated previously by the authors an Read More