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image of Emerging Applications and Innovations in Emulgel Technology for Enhanced Topical Drug Delivery

Abstract

Topical drug delivery systems have garnered significant attention in recent years due to their advantages in localized drug administration, reduced systemic side effects, and enhanced patient compliance. Emulgels, a novel formulation combining the benefits of emulsions and gels, have emerged as a promising approach for improving the topical delivery of anti-inflammatory drugs. This review highlights the evolving trends in emulgel technology, focusing on their unique properties, formulation techniques, and advantages over traditional topical systems. The incorporation of anti-inflammatory drugs into emulgel systems enhances drug solubility, provides sustained release, and improves skin penetration, making them highly effective in treating conditions like arthritis, dermatitis, and other inflammatory disorders. Additionally, emerging trends such as the use of bio-based polymers, nanotechnology, and targeted delivery systems are discussed, emphasizing their potential to revolutionize the topical delivery of anti-inflammatory agents. This article provides a comprehensive overview of the recent advancements in emulgel formulations and their prospects in pharmaceutical applications.

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/content/journals/ddl/10.2174/0122103031384904250930153320
2025-10-03
2025-12-15
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References

  1. Almoshari Y. Novel hydrogels for topical applications: An updated comprehensive review based on source. Gels 2022 8 3 174 10.3390/gels8030174 35323287
    [Google Scholar]
  2. Adepu S. Ramakrishna S. Controlled drug delivery systems: Current status and future directions. Molecules 2021 26 19 5905 10.3390/molecules26195905 34641447
    [Google Scholar]
  3. Bindu S. Mazumder S. Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem. Pharmacol. 2020 180 114147 10.1016/j.bcp.2020.114147 32653589
    [Google Scholar]
  4. Algahtani M.S. Ahmad M.Z. Ahmad J. Nanoemulsion loaded polymeric hydrogel for topical delivery of curcumin in psoriasis. J. Drug Deliv. Sci. Technol. 2020 59 101847 10.1016/j.jddst.2020.101847
    [Google Scholar]
  5. Taléns-Visconti R. Belarbi Y. Díez-Sales O. Julián-Ortiz J.V. Vila-Busó O. Nácher A. A New Hyaluronic Emulgel of Hesperetin for Topical Application-An In Vitro Evaluation. J. Funct. Biomater. 2024 15 4 89 10.3390/jfb15040089 38667546
    [Google Scholar]
  6. Sah S.K. Badola A. Nayak B.K. Emulgel: Magnifying the application of topical drug delivery. Indian J. Pharm. Biol. Res. 2017 5 1 25 33 10.30750/ijpbr.5.1.4
    [Google Scholar]
  7. Narendra Umale SWMHSKSKDHSS Emulgel and nano emulgel as topical drug delivery system. Int. J. Pharm. Sci. 2025 10.5281/ZENODO.14622532
    [Google Scholar]
  8. Indresh Kumar S.K. Emulgels: Revolutionizing topical and transdermal drug delivery. Int. J. Pharma Sci. 2025 3 2840 2850
    [Google Scholar]
  9. Tian Y. Zhou J. He C. The formation, stabilization and separation of oil-water emulsions: A review. Processes (Basel) 2022 10 4 738 10.3390/pr10040738
    [Google Scholar]
  10. Saffarionpour S. One-step preparation of double emulsions stabilized with amphiphilic and stimuli-responsive block copolymers and nanoparticles for nutraceuticals and drug delivery. JCIS Open 2021 3 100020 10.1016/j.jciso.2021.100020
    [Google Scholar]
  11. Zakzak K. Semenescu A.D. Moacă E.A. Comprehensive biosafety profile of carbomer-based hydrogel formulations incorporating phosphorus derivatives. Gels 2024 10 7 477 10.3390/gels10070477 39057500
    [Google Scholar]
  12. Kankane M. Nigam V. Modi S. Emulgel: A dual release system for hydrophobic drug delivery. World J. Basic Pharm. Health. Sci. 2022 12 335 347
    [Google Scholar]
  13. Sereti V. Kotsiou K. Biliaderis C.G. Moschakis T. Lazaridou A. Development of oil-in-water emulsion gels enriched with barley β-glucan as potential solid fat substitute and evaluation of their physical properties. Food Hydrocoll. 2023 145 109090 10.1016/j.foodhyd.2023.109090
    [Google Scholar]
  14. Mazurkevičiūtė A. Matulytė I. Ivaškienė M. Žilius M. Assessment of physical, mechanical, biopharmaceutical properties of emulgels and bigel containing ciclopirox olamine. Polymers (Basel) 2022 14 14 2783 10.3390/polym14142783 35890559
    [Google Scholar]
  15. Naga Sravan Kumar Varma V. Maheshwari P.V. Navya M. Reddy S.C. Shivakumar H.G. Gowda D.V. Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharm. J. 2014 22 6 591 599 10.1016/j.jsps.2014.02.007 25561873
    [Google Scholar]
  16. Rathore P.N. Pal A. Pandey S. A review on exploring the emerging role of novel transdermal gel drug delivery systems for skin diseases. Next Res. 2025 2 6 100373 10.1016/j.nexres.2025.100373
    [Google Scholar]
  17. Ashara K.C. Paun J.S. Soniwala M.M. Chavda J.R. Mendapara V.P. Mori N.M. Microemulgel: An overwhelming approach to improve therapeutic action of drug moiety. Saudi Pharm. J. 2016 24 4 452 457 10.1016/j.jsps.2014.08.002 27330376
    [Google Scholar]
  18. Preeti S.S. Sambhakar S. Malik R. Bhatia S. Al Harrasi A. Rani C. Saharan R. Kumar S. Geeta; Sehrawat, R. Nanoemulsion: An emerging novel technology for improving the bioavailability of drugs. Scientifica (Cairo) 2023 2023 1 25 10.1155/2023/6640103 37928749
    [Google Scholar]
  19. Chime S.A. Kenechukwu F.C. Attama A.A. Nanoemulsions - Advances in formulation, characterization and applications in drug delivery. Appl. Nanotechnol. Drug Deliv 2014 25 10.5772/58673
    [Google Scholar]
  20. Joseph T.M. Kar Mahapatra D. Esmaeili A. Nanoparticles: Taking a unique position in medicine. Nanomaterials (Basel) 2023 13 3 574 10.3390/nano13030574 36770535
    [Google Scholar]
  21. Sghier K. Mur M. Veiga F. Paiva-Santos A.C. Pires P.C. Novel therapeutic hybrid systems using hydrogels and nanotechnology: A focus on nanoemulgels for the treatment of skin diseases. Gels 2024 10 1 45 10.3390/gels10010045 38247768
    [Google Scholar]
  22. Nikolaev B. Yakovleva L. Fedorov V. Nano- and microemulsions in biomedicine: From theory to practice. Pharmaceutics 2023 15 7 1989 10.3390/pharmaceutics15071989
    [Google Scholar]
  23. Pavoni L. Perinelli D.R. Bonacucina G. An overview of micro- and nanoemulsions as vehicles for essential oils: Formulation, preparation and stability. Nanomaterials (Basel) 2020 10 1 135 10.3390/nano10010135 31940900
    [Google Scholar]
  24. Yadav K.S. Soni G. Choudhary D. Khanduri A. Bhandari A. Joshi G. Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration. Med. Drug Discov 2023 20 100162 10.1016/j.medidd.2023.100162
    [Google Scholar]
  25. Alfaro-Rodríguez M.C. Prieto P. García M.C. Martín-Piñero M.J. Muñoz J. Influence of nanoemulsion/gum ratio on droplet size distribution, rheology and physical stability of nanoemulgels containing inulin and omega‐3 fatty acids. J. Sci. Food Agric. 2022 102 14 6397 6403 10.1002/jsfa.12005 35553436
    [Google Scholar]
  26. Alvarez-Lorenzo C. Concheiro A. Effects of surfactants on gel behavior. Am. J. Drug Deliv. 2003 1 77 101
    [Google Scholar]
  27. Vavia P. Vavia P. Bromocriptine nanoemulsion-loaded transdermal gel: Optimization using factorial design, in vitro and in vivo evaluation. AAPS PharmSciTech 2020 21 3 80 10.1208/s12249‑020‑1620‑8 31975311
    [Google Scholar]
  28. Goldberg M. Langer R. Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J. Biomater. Sci. Polym. Ed. 2007 18 3 241 268 10.1163/156856207779996931 17471764
    [Google Scholar]
  29. Said dos Santos R. Bassi da Silva J. Rosseto H.C. Vecchi C.F. Campanholi K.S.S. Caetano W. Bruschi M.L. Emulgels containing propolis and curcumin: The effect of type of vegetable oil, poly(acrylic acid) and bioactive agent on physicochemical stability, mechanical and rheological properties. Gels 2021 7 3 120 10.3390/gels7030120 34449614
    [Google Scholar]
  30. Saraf S. Kaur C.D. In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy Res. 2010 2 1 22 25 10.4103/0974‑8490.60586 21808534
    [Google Scholar]
  31. Buarque F.S. Gautério G.V. Coelho M.A.Z. Aqueous two-phase systems based on ionic liquids and deep eutectic solvents as a tool for the recovery of non-protein bioactive compounds-A review. Processes (Basel) 2023 11 1 31 10.3390/pr11010031
    [Google Scholar]
  32. Seneca S. Pramanik S.K. D’Olieslaeger L. Reekmans G. Vanderzande D. Adriaensens P. Ethirajan A. Nanocapsules with stimuli-responsive moieties for controlled release employing light and enzymatic triggers. Mater. Chem. Front. 2020 4 7 2103 2112 10.1039/D0QM00244E
    [Google Scholar]
  33. Naharros-Molinero A. Caballo-González M.Á. de la Mata F.J. García-Gallego S. Shell formulation in soft gelatin capsules: Design and characterization. Adv. Healthc. Mater. 2024 13 1 2302250 10.1002/adhm.202302250 37775861
    [Google Scholar]
  34. Gupta B. Mishra V. Gharat S. Momin M. Omri A. Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems. Pharmaceuticals 2021 14 11 1201 10.3390/ph14111201 34832983
    [Google Scholar]
  35. Xu Y. Sun L. Zhuang Y. Gu Y. Cheng G. Fan X. Ding Y. Liu H. Protein-stabilized emulsion gels with improved emulsifying and gelling properties for the delivery of bioactive ingredients: A review. Foods 2023 12 14 2703 10.3390/foods12142703 37509795
    [Google Scholar]
  36. Li A. Gong T. Hou Y. Yang X. Guo Y. Alginate-stabilized thixotropic emulsion gels and their applications in fabrication of low-fat mayonnaise alternatives. Int. J. Biol. Macromol. 2020 146 821 831 10.1016/j.ijbiomac.2019.10.050 31726145
    [Google Scholar]
  37. Zheng Y. Ouyang W.Q. Wei Y.P. Syed S. Hao C.S. Wang B.Z. Shang Y.H. Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: A skin permeation study. Int. J. Nanomedicine 2016 11 5971 5987 10.2147/IJN.S119286 27877042
    [Google Scholar]
  38. Tudoroiu E.E. Dinu-Pîrvu C.E. Albu Kaya M.G. Popa L. Anuța V. Prisada R.M. Ghica M.V. An overview of cellulose derivatives-based dressings for wound-healing management. Pharmaceuticals 2021 14 12 1215 10.3390/ph14121215 34959615
    [Google Scholar]
  39. Jadav M. Pooja D. Adams D.J. Kulhari H. Advances in xanthan gum-based systems for the delivery of therapeutic agents. Pharmaceutics 2023 15 2 402 10.3390/pharmaceutics15020402 36839724
    [Google Scholar]
  40. Abourehab M.A.S. Rajendran R.R. Singh A. Pramanik S. Shrivastav P. Ansari M.J. Manne R. Amaral L.S. Deepak A. Alginate as a promising biopolymer in drug delivery and wound healing: A Review of the State-of-the-Art. Int. J. Mol. Sci. 2022 23 16 9035 10.3390/ijms23169035 36012297
    [Google Scholar]
  41. Safitri FI Nawangsari D Febrina D Overview: Application of Carbopol 940 in gel. 2021 10.2991/AHSR.K.210127.018
    [Google Scholar]
  42. Giuliano E. Paolino D. Fresta M. Cosco D. Mucosal applications of poloxamer 407-based hydrogels: An Overview. Pharmaceutics 2018 10 3 159 10.3390/pharmaceutics10030159 30213143
    [Google Scholar]
  43. Alves T.F.R. Morsink M. Batain F. Applications of natural, semi-synthetic, and synthetic polymers in cosmetic formulations. Cosmetics 2020 7 4 75 10.3390/cosmetics7040075
    [Google Scholar]
  44. Kumar R. Islam T. Nurunnabi M. Mucoadhesive carriers for oral drug delivery. J. Control. Release 2022 351 504 559 10.1016/j.jconrel.2022.09.024 36116580
    [Google Scholar]
  45. Mostafa M. Al Fatease A. Alany R.G. Abdelkader H. Recent advances of ocular drug delivery systems: Prominence of ocular implants for chronic eye diseases. Pharmaceutics 2023 15 6 1746 10.3390/pharmaceutics15061746 37376194
    [Google Scholar]
  46. Garg S.S. Gupta J. Guar gum-based nanoformulations: Implications for improving drug delivery. Int. J. Biol. Macromol. 2023 229 476 485 10.1016/j.ijbiomac.2022.12.271 36603711
    [Google Scholar]
  47. Ciolacu D.E. Nicu R. Ciolacu F. Cellulose-based hydrogels as sustained drug-delivery systems. Materials (Basel) 2020 13 22 5270 10.3390/ma13225270 33233413
    [Google Scholar]
  48. Saeed S. Barkat K. Ashraf M.U. Shabbir M. Anjum I. Badshah S.F. Aamir M. Malik N.S. Tariq A. Ullah R. Flexible topical hydrogel patch loaded with antimicrobial drug for accelerated wound healing. Gels 2023 9 7 567 10.3390/gels9070567 37504446
    [Google Scholar]
  49. Neamtu B. Barbu A. Negrea M.O. Berghea-Neamțu C.Ș. Popescu D. Zăhan M. Mireșan V. Carrageenan-based compounds as wound healing materials. Int. J. Mol. Sci. 2022 23 16 9117 10.3390/ijms23169117 36012381
    [Google Scholar]
  50. Redkar M.R. Hasabe P.S. Jadhav S.T. Mane P.S. Kare D.J. Review on optimization base emulgel formulation. Asian J. Pharm. Technol 2019 9 3 228 237 10.5958/2231‑5713.2019.00038.2
    [Google Scholar]
  51. Shahin M. Abdel Hady S. Hammad M. Mortada N. Novel jojoba oil-based emulsion gel formulations for clotrimazole delivery. AAPS PharmSciTech 2011 12 1 239 247 10.1208/s12249‑011‑9583‑4 21225383
    [Google Scholar]
  52. Lukić M. Pantelić I. Savić, SD Towards optimal pH of the skin and topical formulations: From the current state of the art to tailored products. Cosmetics 2021 8 3 69 10.3390/cosmetics8030069
    [Google Scholar]
  53. Costa C. Medronho B. Filipe A. Mira I. Lindman B. Edlund H. Norgren M. Emulsion formation and stabilization by biomolecules: The leading role of cellulose. Polymers (Basel) 2019 11 10 1570 10.3390/polym11101570 31561633
    [Google Scholar]
  54. Tian Y. Sun F. Wang Z. Yuan C. Wang Z. Guo Z. Zhou L. Research progress on plant-based protein Pickering particles: Stabilization mechanisms, preparation methods, and application prospects in the food industry. Food Chem. X 2024 21 101066 10.1016/j.fochx.2023.101066 38268843
    [Google Scholar]
  55. Mileti O. Baldino N. Luzzi S. Lupi F.R. Gabriele D. Interfacial rheological study of β-casein/pectin mixtures at the air/water interface. Gels 2024 10 1 41 10.3390/gels10010041 38247764
    [Google Scholar]
  56. Sun J. Dai L. Lv K. Wen Z. Li Y. Yang D. Yan H. Liu X. Liu C. Li M.C. Recent advances in nanomaterial-stabilized pickering foam: Mechanism, classification, properties, and applications. Adv. Colloid Interface Sci. 2024 328 103177 10.1016/j.cis.2024.103177 38759448
    [Google Scholar]
  57. Schafer N. Balwierz R. Biernat P. Ochędzan-Siodłak W. Lipok J. Natural ingredients of transdermal drug delivery systems as permeation enhancers of active substances through the stratum corneum. Mol. Pharm. 2023 20 7 3278 3297 10.1021/acs.molpharmaceut.3c00126 37279070
    [Google Scholar]
  58. Honvo G. Leclercq V. Geerinck A. Thomas T. Veronese N. Charles A. Rabenda V. Beaudart C. Cooper C. Reginster J.Y. Bruyère O. Safety of topical non-steroidal anti-inflammatory drugs in osteoarthritis: Outcomes of a systematic review and meta-analysis. Drugs Aging 2019 36 S1 45 64 (Suppl. 1) 10.1007/s40266‑019‑00661‑0 31073923
    [Google Scholar]
  59. Otto F. Froelich A. Microemulsion-based polymer gels with ketoprofen and menthol: Physicochemical properties and drug release studies. Gels 2024 10 7 435 10.3390/gels10070435 39057458
    [Google Scholar]
  60. Pradal J. Vallet C. Frappin G. Bariguian F. Lombardi M.S. Importance of the formulation in the skin delivery of topical diclofenac: Not all topical diclofenac formulations are the same. J. Pain Res. 2019 12 1149 1154 10.2147/JPR.S191300 31114298
    [Google Scholar]
  61. Osborne D.W. Musakhanian J. Skin penetration and permeation properties of transcutol®-neat or diluted mixtures. AAPS PharmSciTech 2018 19 8 3512 3533 10.1208/s12249‑018‑1196‑8 30421383
    [Google Scholar]
  62. Kim M. Lee E.J. Lim K.M. Ibuprofen increases the hepatotoxicity of ethanol through potentiating oxidative stress. Biomol. Ther. (Seoul) 2021 29 2 205 210 10.4062/biomolther.2020.108 33024059
    [Google Scholar]
  63. Nair B. Taylor-Gjevre R. A review of topical diclofenac use in musculoskeletal disease. Pharmaceuticals 2010 3 6 1892 1908 10.3390/ph3061892 27713334
    [Google Scholar]
  64. Derry S. Conaghan P. Da Silva J.A.P. Wiffen P.J. Moore R.A. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Libr. 2016 2020 2 CD007400 10.1002/14651858.CD007400.pub3 27103611
    [Google Scholar]
  65. Schwartzberg L.S. Navari R.M. Safety of polysorbate 80 in the oncology setting. Adv. Ther. 2018 35 6 754 767 10.1007/s12325‑018‑0707‑z 29796927
    [Google Scholar]
  66. Sakeena M.H.F. Elrashid S.M. Muthanna F.A. Ghassan Z.A. Kanakal M.M. Laila L. Munavvar A.S. Azmin M.N. Effect of limonene on permeation enhancement of ketoprofen in palm oil esters nanoemulsion. J. Oleo Sci. 2010 59 7 395 400 10.5650/jos.59.395 20513974
    [Google Scholar]
  67. Oshizaka T. Kodera S. Kawakubo R. Takeuchi I. Mori K. Sugibayashi K. Enhanced drug skin permeation by azone-mimicking ionic liquids: Effects of fatty acids forming ionic liquids. Pharmaceutics 2024 17 1 41 10.3390/pharmaceutics17010041 39861689
    [Google Scholar]
  68. Shah P.N. Marshall-Batty K.R. Smolen J.A. Tagaev J.A. Chen Q. Rodesney C.A. Le H.H. Gordon V.D. Greenberg D.E. Cannon C.L. Antimicrobial activity of ibuprofen against cystic fibrosis-associated gram-negative pathogens. Antimicrob. Agents Chemother. 2018 62 3 e01574 e17 10.1128/AAC.01574‑17 29311081
    [Google Scholar]
  69. Yu W. Guo J. Liu Y. Xue X. Wang X. Wei L. Ma J. Potential impact of combined inhibition by bacteriocins and chemical substances of foodborne pathogenic and spoilage bacteria: A review. Foods 2023 12 16 3128 10.3390/foods12163128 37628127
    [Google Scholar]
  70. Stroppel L. Schultz-Fademrecht T. Cebulla M. Blech M. Marhöfer R.J. Selzer P.M. Garidel P. Antimicrobial preservatives for protein and peptide formulations: An overview. Pharmaceutics 2023 15 2 563 10.3390/pharmaceutics15020563 36839885
    [Google Scholar]
  71. Milutinov J. Krstonošić V. Ćirin D. Pavlović N. Emulgels: Promising carrier systems for food ingredients and drugs. Polymers (Basel) 2023 15 10 2302 10.3390/polym15102302 37242878
    [Google Scholar]
  72. Tadić V.M. Žugić A. Martinović M. Enhanced skin performance of emulgel vs. cream as systems for topical delivery of herbal actives (immortelle extract and hemp oil). Pharmaceutics 2021 13 11 1919 10.3390/pharmaceutics13111919 34834334
    [Google Scholar]
  73. Patel B.M. Kuchekar A.B. Pawar S.R. Emulgel approach to formulation development: A review. Biosci. Biotechnol. Res. Asia 2021 18 3 459 465 10.13005/bbra/2931
    [Google Scholar]
  74. Fadaei M.S. Fadaei M.R. Kheirieh A.E. Rahmanian-Devin P. Dabbaghi M.M. Nazari Tavallaei K. Shafaghi A. Hatami H. Baradaran Rahimi V. Nokhodchi A. Askari V.R. Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds. EXCLI J. 2024 23 212 263 38487088
    [Google Scholar]
  75. Charyulu N.R. Joshi P. Dubey A. Shetty A. Emulgel: A boon for enhanced topical drug delivery. J. Young Pharm. 2021 13 1 76 79 10.5530/jyp.2021.13.17
    [Google Scholar]
  76. Charles A. Janeway J. Travers P. Walport M. Effector mechanisms in allergic reactions. 2024 Available From: https://www.ncbi.nlm.nih.gov/books/NBK27112/
    [Google Scholar]
  77. Souto E.B. Fangueiro J.F. Fernandes A.R. Cano A. Sanchez-Lopez E. Garcia M.L. Severino P. Paganelli M.O. Chaud M.V. Silva A.M. Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery. Heliyon 2022 8 2 e08938 10.1016/j.heliyon.2022.e08938 35198788
    [Google Scholar]
  78. Lal D.K. Kumar B. Saeedan A.S. An overview of nanoemulgels for bioavailability enhancement in inflammatory conditions via topical delivery. Pharmaceutics 2023 15 4 1187 10.3390/pharmaceutics15041187 37111672
    [Google Scholar]
  79. Drosopoulou K. Kosheleva R.I. Ofrydopoulou, A Topical and transdermal delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) for inflammation and pain: Current trends and future directions in delivery systems. Processes (Basel) 2025 13 3 907 10.3390/pr13030907
    [Google Scholar]
  80. Haltner-Ukomadu E. Sacha M. Richter A. Hussein K. Hydrogel increases diclofenac skin permeation and absorption. Biopharm. Drug Dispos. 2019 40 7 217 224 10.1002/bdd.2194 31242332
    [Google Scholar]
  81. El Bejjaji S. Ramos-Yacasi G. Suñer-Carbó J. Mallandrich M. Goršek L. Quilchez C. Calpena A.C. Nanocomposite gels loaded with flurbiprofen: Characterization and skin permeability assessment in different skin species. Gels 2024 10 6 362 10.3390/gels10060362 38920910
    [Google Scholar]
  82. Khullar R. Kumar D. Seth N. Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm. J. 2012 20 1 63 67 10.1016/j.jsps.2011.08.001 23960777
    [Google Scholar]
  83. Jain A. Gautam S.P. Gupta Y. Development and characterization of ketoconazole emulgel fortopical drug delivery. Der Pharm. Sin. 2025 1 3 221 231
    [Google Scholar]
  84. Magre S. Jain R.K. Khare B. Jain V. Khangar P.K. Formulation and evaluation of flurbiprofen topical emulgels. Int. J. Med. Sci. Pharma Res. 2022 8 3 22 27 10.22270/ijmspr.v8i3.55
    [Google Scholar]
  85. Ambhore N.P. Dandagi P.M. Gadad A.P. Mandora P. Formulation and characterization of tapentadol loaded emulgel for topical application. Indian J. Pharm. Educ. Res. 2017 51 4 525 535 10.5530/ijper.51.4.81
    [Google Scholar]
  86. Amminbavi D. Lakshmi N.P. Assessment of In vitro wound healing potential of Hibiscus leaf extract Emulgel. Asian J. Pharm. Res. 2020 10 2 67 72 10.5958/2231‑5691.2020.00013.1
    [Google Scholar]
  87. Sriaandhal Sabalingam Siriwardhene, M.A. A review on emerging applications of emulgel as topical drug delivery system. Na J. Adv. Res. Rev. 2022 13 1 452 463 10.30574/wjarr.2022.13.1.0048
    [Google Scholar]
  88. Jain A. Kumar P. Verma A. Mohanta B.C. Ashique S. Pal R. Kumar S. Mishra N. Emulgel: A cutting edge approach for topical drug delivery system. Curr. Drug Res. Rev. 2024 16 2 10.2174/0125899775278612240129055753 38303537
    [Google Scholar]
  89. Yu Y.Q. Yang X. Wu X.F. Fan Y.B. Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: Novel strategies for effective transdermal applications. Front. Bioeng. Biotechnol. 2021 9 646554 10.3389/fbioe.2021.646554 33855015
    [Google Scholar]
  90. Donthi M.R. Munnangi S.R. Krishna K.V. Saha R.N. Singhvi G. Dubey S.K. Nanoemulgel: A novel nano carrier as a tool for topical drug delivery. Pharmaceutics 2023 15 1 164 10.3390/pharmaceutics15010164 36678794
    [Google Scholar]
  91. Bargakshatriya R. Pramanik S.K. Leading prodrug strategies for targeted and specific release. Future Med. Chem. 2025 17 8 865 868 10.1080/17568919.2025.2479412 40085509
    [Google Scholar]
  92. Maurya R. Misro L. Boini T. Transforming medicinal oil into advanced gel: An update on advancements. Gels 2024 10 5 342 10.3390/gels10050342 38786260
    [Google Scholar]
  93. Singh S. Singh I. Evolving implementation of emulgel as a topical drug delivery system: A systematic review. Curr. Res. Pharm. Sci. 2022 12 3 121 131 10.24092/CRPS.2022.120301
    [Google Scholar]
  94. Dănilă E. Kaya D.A. Anuța V. Formulation and characterization of niacinamide and collagen emulsion and its investigation as a potential cosmeceutical product. Cosmetics 2024 11 2 40 10.3390/cosmetics11020040
    [Google Scholar]
  95. Samari M. Kashanian S. Zinadini S. Derakhshankhah H. Enhanced delivery of azithromycin using asymmetric polyethersulfone membrane modified with KIT-6 mesoporous material: Optimization and mechanistic studies. Eur. J. Pharm. Sci. 2025 207 107038 10.1016/j.ejps.2025.107038 39933630
    [Google Scholar]
  96. Rawat A. Gupta S.S. Kalluri H. Lowenborg M. Bhatia K. Warner K. Rheological characterization in the development of topical drug products. AAPS Advances in the Pharmaceutical Sciences Series 2019 36 3 45 10.1007/978‑3‑030‑17355‑5_1
    [Google Scholar]
  97. Milanowski B. Wosicka-Frąckowiak H. Główka E. Sosnowska M. Woźny S. Stachowiak F. Suchenek A. Wilkowski D. Optimization and evaluation of the in vitro permeation parameters of topical products with non-steroidal anti-inflammatory drugs through strat-m® membrane. Pharmaceutics 2021 13 8 1305 10.3390/pharmaceutics13081305 34452264
    [Google Scholar]
  98. Eddouks M. Chattopadhyay D. Zeggwagh N.A. Animal models as tools to investigate antidiabetic and anti-inflammatory plants. Evid. Based Complement. Alternat. Med. 2012 2012 1 14 10.1155/2012/142087 22899950
    [Google Scholar]
  99. Thomas-Brown P.G. Ruddock P.L. Gossell-Williams M. Phar-macokinetics. PharmacognosyFundamentals, Applications, and Strategies, 2nd ed Academic Press 2023 559 577
    [Google Scholar]
  100. Pachauri A. Chitme H. Visht S. Permeability-enhanced liposomal emulgel formulation of 5-fluorouracil for the treatment of skin cancer. Gels 2023 9 3 209 10.3390/gels9030209 36975657
    [Google Scholar]
  101. Mashabela L.T. Maboa M.M. Miya N.F. A comprehensive review of cross-linked gels as vehicles for drug delivery to treat central nervous system disorders. Gels 2022 8 9 563 10.3390/gels8090563 36135275
    [Google Scholar]
  102. Calienni M.N. Martínez L.M. Izquierdo M.C. Alonso S.V. Montanari J. Rheological and viscoelastic analysis of hybrid formulations for topical application. Pharmaceutics 2023 15 10 2392 10.3390/pharmaceutics15102392 37896152
    [Google Scholar]
  103. Zhang X. Niu J. Wu J. Evaluation and manipulation of the key emulsification factors toward highly stable PCM-water nano-emulsions for thermal energy storage. Sol. Energy Mater. Sol. Cells 2021 219 110820 10.1016/j.solmat.2020.110820
    [Google Scholar]
  104. Simões A. Miranda M. Cardoso C. Veiga F. Vitorino C. Rheology by design: A regulatory tutorial for analytical method validation. Pharmaceutics 2020 12 9 820 10.3390/pharmaceutics12090820 32872221
    [Google Scholar]
  105. Raeisi Estabragh M.A. Sajadi Bami M. Dehghannoudeh G. Noudeh Y.D. Moghimipour E. Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review. Int. J. Biol. Macromol. 2023 241 124538 10.1016/j.ijbiomac.2023.124538 37085064
    [Google Scholar]
  106. Bariguian Revel F. Fayet M. Hagen M. Topical diclofenac, an efficacious treatment for osteoarthritis: A narrative review. Rheumatol. Ther. 2020 7 2 217 236 10.1007/s40744‑020‑00196‑6 32086778
    [Google Scholar]
  107. Sinha A. Garg U. Nagaich U. Chaudhary A. Pandey M. Jain N. Emulgels: A promising topical drug delivery system for arthritis management and care. Pharm. Dev. Technol. 2024 29 1 25 39 10.1080/10837450.2023.2289170 38014878
    [Google Scholar]
  108. Sultana N. Akhtar J. Badruddeen; Irfan Khan, M.; Ahmad, U.; Arif, M.; Ahmad, M.; Upadhyay, T. Nanoemulgel: For promising topical and systemic delivery. Drug Dev. Life. Cycle 2022 11 10.5772/intechopen.103878
    [Google Scholar]
  109. Kola-Mustapha A.T. Ibraheem H.F. Taiwo, S Formulation of Entandrophragma utile into an herbal emulgel for the management of inflammation. Gels 2023 9 12 956 10.3390/gels9120956 38131942
    [Google Scholar]
  110. Wohlrab J. Kreft B. Scholz L.S. Anti-inflammatory topical medication - new developments in the treatment of atopic dermatitis. Allergol. Select 2021 5 1 260 264 10.5414/ALX02255E 34532634
    [Google Scholar]
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