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2000
Volume 15, Issue 3
  • ISSN: 2210-3031
  • E-ISSN: 2210-304X

Abstract

Rectal Drug Delivery System (RDDS) emerges as an alternative administration route due to the rectum's small surface area and limited enzyme activity, which contribute to efficient drug absorption. RDDS offers various advantages, such as reduced first-pass metabolism, rapid absorption of low molecular weight drugs, and the ability to accommodate large retention volumes and facilitate absorption the lymphatic system. Moreover, RDDS is preferable for drugs with low stability, solubility, and permeability oral administration, as well as effectively addressing concerns related to gastric irritation or degradation. This review delves into the factors influencing drug absorption in RDDS, including drug properties, formulation types, and physiological and pathology-associated considerations. It further explores conventional RDDS, including enemas, suppositories, tablets, gels, sprays, ointments, and creams, as well as novel approaches involving nanoparticles, liposomes, microspheres, and solid lipid nanoparticles (SLNs) in rectal dosage forms. Furthermore, the challenges and prospects of RDDS in treating rectal diseases are discussed. This review provides valuable insights into the potential of RDDS, highlighting the importance of continuous research and development in enhancing patient outcomes and advancing healthcare practices.

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2024-10-31
2025-12-15

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Advanced Technologies in Rectal Drug Delivery Systems: A Comprehensive Review of Recent Innovations and Future Prospects
Drug Deliv Lett 15, 163 (2025); https://doi.org/10.2174/0122103031328871241023075235
/content/journals/ddl/10.2174/0122103031328871241023075235
/content/journals/ddl/10.2174/0122103031328871241023075235
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  • Article Type:     Review Article
Keyword(s): advanced technologies; nano-based technologies; nanoparticles; novel polymers, healthcare practices; Rectal drug delivery systems; rectum delivery

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