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2000
Volume 25, Issue 17
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Aim

Our goal was to investigate the use of Cyclodextrin in creating an aqueous extract of Cinnamon with a high content of its bioactive ingredients, validated by cell-based assays.

Background

Due to their safety and cost-effectiveness, natural compounds have garnered attention for cancer therapy, which often faces challenges related to drug toxicity and resistance. Cinnamon (; also known as Ceylon Cinnamon) is a commonly used spice with a history in folk medicine for treating various ailments. However, its active ingredients suffer from poor solubility, stability, and bioavailability, which limits its use and benefits.

Objective

We prepared γCyclodextrin (γCD)-assisted aqueous extract of Cinnamon (CD-CIN) and compared its activity with the DMSO extract (DM-CIN).

Methods

The cells were exposed to CD-CIN and DM-CIN extracts under normal and stressed (oxidative, metal, and hypoxic) conditions and then analyzed for stress and cancerous phenotypes using various molecular assays.

Results

We found that CD-CIN possesses considerable anticancer activity that involves the activation of tumor suppressor proteins and DNA damage response. Low, non-toxic concentrations of DM-CIN and CD-CIN caused comparable inhibition of migration and invasion capability of cells, supported by molecular marker analyses. Furthermore, protection against oxidative, metal, and hypoxia stress, as well as induction of differentiation, was recorded in both DM-CIN and CD-CIN treated cells, as compared to the control.

Conclusion

We report CD-CIN as a new economic and easy Cinnamon-derived resource that possesses considerable anticancer and antistress activities and hence warrants further chemical, and studies.

© 2025 Bentham Science Publishers
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γCyclodextrin-assisted Aqueous Extract of Cinnamon for Cancer and Stress Management
Curr. Top. Med. Chem. 25, 2086 (2025); https://doi.org/10.2174/0115680266309291240808114508
/content/journals/ctmc/10.2174/0115680266309291240808114508
/content/journals/ctmc/10.2174/0115680266309291240808114508
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  • Article Type:     Research Article
Keyword(s): cancer; Cinnamon; management; metastasis; mortalin; p53; stress; γCyclodextrin

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