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2000
Volume 25, Issue 17
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Diosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as , and . It has been shown that diosmetin has pharmacological actions that include neuroprotective, antioxidant, and anticancer properties. The objective of this manuscript is to provide a comprehensive review of the pharmacological, pharmacokinetic, and toxicological profile of diosmetin. The information has been collected from several research papers found in various databases, including Web of Science, Pubmed, Scopus, and ScienceDirect. Diosmetin has the potential to reduce inflammation, and it can also improve vascular functions and protect against oxidative stress, both of which are essential for the prevention and management of several diseases.

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2025-02-17
2026-02-02
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References

  1. LiuR.H. Health benefits of dietary flavonoids: Flavonols and flavones.New York Fru. Quart.20021032124
    [Google Scholar]
  2. ChenYuting Zheng,; Rongliang,; Jia Zhongjian,; Ju Yong, Flavonoids as superoxide scavengers and antioxidants.Free Radic. Biol. Med.199091192110.1016/0891‑5849(90)90045‑K 2170243
    [Google Scholar]
  3. FerrándizM.L. AlcarazM.J. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids.Agents Actions1991323-428328810.1007/BF01980887 1650522
    [Google Scholar]
  4. G, M.S.; Swetha, M.; Keerthana, C.K.; Rayginia, T.P.; Anto, R.J. Cancer chemoprevention: A strategic approach using phytochemicals.Front. Pharmacol.20221280930810.3389/fphar.2021.809308 35095521
    [Google Scholar]
  5. PatelK. GadewarM. TahilyaniV. PatelD.K. A review on pharmacological and analytical aspects of diosmetin: A concise report.Chin. J. Integr. Med.2013191079280010.1007/s11655‑013‑1595‑3 24092244
    [Google Scholar]
  6. MeirinhosJ. SilvaB.M. ValentÃo, P.; Seabra, R.M.; Pereira, J.A.; Dias, A.; Andrade, P.B.; Ferreres, F. Analysis and quantification of flavonoidic compounds from Portuguese olive (Olea Europaea L.) leaf cultivars.Nat. Prod. Res.200519218919510.1080/14786410410001704886 15715265
    [Google Scholar]
  7. GargM. ChaudharyS.K. GoyalA. SarupP. KumariS. GargN. VaidL. ShiveenaB. Comprehensive review on therapeutic and phytochemical exploration of diosmetin: A promising moiety.Phytomed. Plus20222110017910.1016/j.phyplu.2021.100179
    [Google Scholar]
  8. ChenY. WangY. LiuM. ZhouB. YangG. Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways.Phytother. Res.20203461310131910.1002/ptr.6596 31833613
    [Google Scholar]
  9. GeA. MaY. LiuY.N. LiY.S. GuH. ZhangJ.X. WangQ.X. ZengX.N. HuangM. Diosmetin prevents TGF-β1-induced epithelial-mesenchymal transition via ROS/MAPK signaling pathways.Life Sci.20161531810.1016/j.lfs.2016.04.023 27101925
    [Google Scholar]
  10. XieB. PanD. LiuH. LiuM. ShiX. ChuX. LuJ. ZhuM. XiaB. WuJ. Diosmetin protects against obesity and metabolic dysfunctions through activation of adipose estrogen receptors in mice.Mol. Nutr. Food Res.20216517210007010.1002/mnfr.202100070 34223710
    [Google Scholar]
  11. KahnS.R. The clinical diagnosis of deep venous thrombosis: Integrating incidence, risk factors, and symptoms and signs.Arch. Intern. Med.1998158212315232310.1001/archinte.158.21.2315 9827782
    [Google Scholar]
  12. MiyakeY. MochizukiM. OkadaM. HiramitsuM. MorimitsuY. OsawaT. Isolation of antioxidative phenolic glucosides from lemon juice and their suppressive effect on the expression of blood adhesion molecules.Biosci. Biotechnol. Biochem.20077181911191910.1271/bbb.70115 17690486
    [Google Scholar]
  13. CaristiC. BelloccoE. GargiulliC. ToscanoG. LeuzziU. Flavone-di-C-glycosides in juices from Southern Italy.Food Chem.200695343143710.1016/j.foodchem.2005.01.031
    [Google Scholar]
  14. PeregoR. BeccagliaP. AngeliniM. VillaP. CovaD. Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver.Xenobiotica199323121345135210.3109/00498259309059444 8135038
    [Google Scholar]
  15. MastudaH. MorikawaT. UedaK. ManagiH. YoshikawaM. Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-α and IL-4 production from RBL-2H3 cells.Bioorg. Med. Chem.200210103123312810.1016/S0968‑0896(02)00227‑4 12150856
    [Google Scholar]
  16. XiaJ. LiJ. DengM. YinF. LiuJ. WangJ. Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function.Inflammopharmacology20233142037204710.1007/s10787‑023‑01228‑7 37074600
    [Google Scholar]
  17. HvattumE. EkebergD. Study of the collision‐induced radical cleavage of flavonoid glycosides using negative electrospray ionization tandem quadrupole mass spectrometry.J. Mass Spectrom.2003381434910.1002/jms.398 12526005
    [Google Scholar]
  18. DongX. HuangH. WangR. LuoS. MiY. PanY. ShenW. CuiJ. HuX. ChengX. ShiX. WangH. High‐speed counter‐current chromatography assisted preparative isolation of phenolic compounds from the flowers of Chrysanthemum morifolium cv.Fubaiju. J. Sep. Sci.20234619230017210.1002/jssc.202300172 37528737
    [Google Scholar]
  19. KalaycıB. Şimşek ÖzekN. AysinF. ÖzbekH. KazazC. ÖnalM. GüvenalpZ. Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC.Saudi Pharm. J.202331810168210.1016/j.jsps.2023.06.015 37448848
    [Google Scholar]
  20. HuangY. GongZ. YanC. ZhengK. ZhangL. LiJ. LiangE. ZhangL. MaoJ. Investigation on the mechanisms of Zanthoxylum bungeanum for treating diabetes mellitus based on network pharmacology, molecular docking, and experiment verification.BioMed Res. Int.202320231929872810.1155/2023/9298728 36874926
    [Google Scholar]
  21. JöhrerK. Galarza PérezM. KircherB. ÇiçekS.S. Flavones, flavonols, lignans, and caffeic acid derivatives from Dracocephalum moldavica and their in vitro effects on multiple myeloma and acute myeloid leukemia.Int. J. Mol. Sci.202223221421910.3390/ijms232214219 36430695
    [Google Scholar]
  22. ErenlerR. YildizI. AydinA. GencN. Antiproliferative and cytotoxic effects of bioactive compounds isolated from Onosma bourgaei.Med. Oncol.202239811610.1007/s12032‑022‑01705‑z 35674858
    [Google Scholar]
  23. El GizawyH.A. El-HaddadA.E. SaadeldeenA.M. BoshraS.A. Tentatively identified (UPLC/T-TOF–MS/MS) compounds in the extract of Saussurea costus roots exhibit in vivo hepatoprotection via modulation of HNF-1α, Sirtuin-1, C/Ebpα, MiRNA-34a and MiRNA-223.Molecules2022279280210.3390/molecules27092802 35566153
    [Google Scholar]
  24. KhanJ. SakibS.A. MahmudS. KhanZ. IslamM.N. SakibM.A. EmranT.B. Simal-GandaraJ. Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: Molecular docking, molecular dynamic simulations and quantum computations.J. Biomol. Struct. Dyn.20224021107411075210.1080/07391102.2021.1947893 34278965
    [Google Scholar]
  25. JiM. WangC. YangT. MengX. WangX. LiM. Integrated phytochemical analysis based on UPLC–MS/MS and network pharmacology approaches to explore the effect of Odontites vulgaris Moench on rheumatoid arthritis.Front. Pharmacol.20211270768710.3389/fphar.2021.707687 34526896
    [Google Scholar]
  26. MoharramF.A. NagyM.M. El DibR.A. el-TantawyM.M. El HossaryG.G. El-HosariD.G. Pharmacological activity and flavonoids constituents of Artemisia judaica L aerial parts.J. Ethnopharmacol.202127011377710.1016/j.jep.2021.113777 33412247
    [Google Scholar]
  27. ZhangR. HuX. ZhangB. WangZ. HaoC. XinJ. GuoQ. Whitening activity of constituents isolated from the Trichosanthes pulp.Evid. Based Complement. Alternat. Med.202020201258257910.1155/2020/2582579 32774406
    [Google Scholar]
  28. BenvenuttiR.C. Dalla VecchiaC.A. LocateliG. SerpaP.Z. LutinskiJ.A. Rodrigues JuniorS.A. CorraloV. GutiérrezM.V. VilegasW. SomensiL.B. LongoB. KnihsJ.F. Mota da SilvaL. de AndradeS.F. Roman JuniorW.A. Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents.J. Ethnopharmacol.202025011247310.1016/j.jep.2019.112473 31836518
    [Google Scholar]
  29. YanY. LiuX. GaoJ. WuY. LiY. Inhibition of TGF-β Signaling in Gliomas by the Flavonoid diosmetin isolated from Dracocephalum peregrinum L.Molecules202025119210.3390/molecules25010192 31906574
    [Google Scholar]
  30. DeipenbrockM. HenselA. Polymethoxylated flavones from Orthosiphon stamineus leaves as antiadhesive compounds against uropathogenic E. coli.Fitoterapia201913910438710.1016/j.fitote.2019.104387 31678632
    [Google Scholar]
  31. ChoiJ. LeeD.H. ParkS.Y. SeolJ.W. Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer.Biomed. Pharmacother.201911710909110.1016/j.biopha.2019.109091 31228803
    [Google Scholar]
  32. HuZ. CaiB. WangM. WenX. GengA. HuX. XueR. MaoZ. JiangY. WanX. Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer.Cell Cycle202019223115312610.1080/15384101.2020.1831257 33064975
    [Google Scholar]
  33. WangJ. MaS. LiL. ChenY. YangQ. WangF. ZhengM. MiaoS. ShiX. Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics.Front. Pharmacol.20221398382110.3389/fphar.2022.983821 36060002
    [Google Scholar]
  34. KooshaS. MohamedZ. SinniahA. AlshawshM.A. Evaluation of anti-tumorigenic effects of diosmetin against human colon cancer xenografts in athymic nude mice.Molecules20192414252210.3390/molecules24142522 31295840
    [Google Scholar]
  35. SongC. DengS. HuH. ZhengZ. ShenB. WuX. HuangM. WangJ. WangZ. Diosmetin affects gene expression on human lung adenocarcinoma cells.J. Oncol.202220221910.1155/2022/5482148 35646118
    [Google Scholar]
  36. MaA. ZhangR. Diosmetin inhibits cell proliferation, induces cell apoptosis and cell cycle arrest in liver cancer.Cancer Manag. Res.2020123537354610.2147/CMAR.S240064 32547191
    [Google Scholar]
  37. LiuJ. WenX. LiuB. ZhangQ. ZhangJ. MiaoH. ZhuR. Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP-2 and MMP-9.Mol. Med. Rep.20161332401240810.3892/mmr.2016.4872 26847170
    [Google Scholar]
  38. ZhaoF. HongX. LiD. WeiZ. CiX. ZhangS. Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway.Med. Oncol.20213855410.1007/s12032‑021‑01501‑1 33811596
    [Google Scholar]
  39. KamranS. SinniahA. ChikZ. AlshawshM.A. Diosmetin exerts synergistic effects in combination with 5-fluorouracil in colorectal cancer cells.Biomedicines202210353110.3390/biomedicines10030531 35327333
    [Google Scholar]
  40. LiuY. ShaoZ. LiaoY. XiaX. HuangC. HeJ. HuT. YuC. JiangL. LiuJ. HuangH. Targeting SKP2/Bcr-Abl pathway with Diosmetin suppresses chronic myeloid leukemia proliferation.Eur. J. Pharmacol.202088317336610.1016/j.ejphar.2020.173366 32679184
    [Google Scholar]
  41. OakC. KhalifaA. IsaliI. BhaskaranN. WalkerE. ShuklaS. Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest.Int. J. Oncol.201853283584310.3892/ijo.2018.4407 29767250
    [Google Scholar]
  42. QiuM. LiuJ. SuY. GuoR. ZhaoB. LiuJ. Diosmetin induces apoptosis by downregulating AKT phosphorylation via P53 activation in human renal carcinoma ACHN cells.Protein Pept. Lett.202027101022102810.2174/0929866527666200330172646 32223728
    [Google Scholar]
  43. XuZ. YanY. XiaoL. DaiS. ZengS. QianL. WangL. YangX. XiaoY. GongZ. Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway.PLoS One2017124e017597710.1371/journal.pone.0175977 28414793
    [Google Scholar]
  44. LiuJ. RenH. LiuB. ZhangQ. LiM. ZhuR. Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells.Oncol. Lett.20161264385439210.3892/ol.2016.5301 28101201
    [Google Scholar]
  45. BoisnicS. BranchetM.C. Quioc-SalomonB. DoanJ. DelvaC. GendronC. Anti-inflammatory and antioxidant effects of diosmetin-3-O-β-d-glucuronide, the main metabolite of diosmin: Evidence from ex vivo human skin models.Molecules20232814559110.3390/molecules28145591 37513462
    [Google Scholar]
  46. WangB.S. HuangG.J. TaiH.M. HuangM.H. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq.Food Chem. Toxicol.2012503-452653110.1016/j.fct.2011.12.010 22198607
    [Google Scholar]
  47. MeephatS. PrasatthongP. PotueP. BunbuphaS. PakdeechoteP. ManeesaiP. Diosmetin ameliorates vascular dysfunction and remodeling by modulation of Nrf2/HO-1 and p-JNK/p-NF-κB expression in hypertensive rats.Antioxidants2021109148710.3390/antiox10091487 34573119
    [Google Scholar]
  48. ShiM. WangJ. BiF. BaiZ. Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition.Environ. Toxicol.20223761529154210.1002/tox.23504 35191607
    [Google Scholar]
  49. SaghaeiE. Nasiri BoroujeniS. SafaviP. Borjian BoroujeniZ. BijadE. Diosmetin mitigates cognitive and memory impairment provoked by chronic unpredictable mild stress in mice.Evid. Based Complement. Alternat. Med.202020201572536110.1155/2020/5725361 33414836
    [Google Scholar]
  50. ZhangY. JiangY. LuD. Diosmetin suppresses neuronal apoptosis and inflammation by modulating the phosphoinositide 3-kinase (PI3K)/AKT/nuclear factor-κB (NF-κB) signaling pathway in a rat model of pneumococcal meningitis.Med. Sci. Monit.2019252238224510.12659/MSM.911860 30914630
    [Google Scholar]
  51. AhmadT. KhanT. KiraboA. ShahA.J. Antioxidant flavonoid diosmetin is cardioprotective in a rat model of myocardial infarction induced by beta 1-adrenergic receptors activation.Curr. Issues Mol. Biol.20234564675468610.3390/cimb45060297 37367046
    [Google Scholar]
  52. MoG. HeY. ZhangX. LeiX. LuoQ. RETRACTED: Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis.Clin. Exp. Pharmacol. Physiol.202047101713172210.1111/1440‑1681.13309 32219867
    [Google Scholar]
  53. YangK. LiW.F. YuJ.F. YiC. HuangW.F. Diosmetin protects against ischemia/reperfusion-induced acute kidney injury in mice.J. Surg. Res.2017214697810.1016/j.jss.2017.02.067 28624062
    [Google Scholar]
  54. AlqahtaniM.J. NegmW.A. SaadH.M. SalemE.A. HusseinI.A. IbrahimH.A. Fenofibrate and Diosmetin in a rat model of testicular toxicity: New insight on their protective mechanism through PPAR-α/NRF-2/HO-1 signaling pathway.Biomed. Pharmacother.202316511509510.1016/j.biopha.2023.115095 37413905
    [Google Scholar]
  55. LiuQ. CiX. WenZ. PengL. Diosmetin alleviates lipopolysaccharide-induced acute lung injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.Biomol. Ther. (Seoul)201826215716610.4062/biomolther.2016.234 28365974
    [Google Scholar]
  56. ParkS. BongS.K. LeeJ.W. ParkN.J. ChoiY. KimS.M. YangM.H. KimY.K. KimS.N. Diosmetin and its glycoside, diosmin, improve atopic dermatitis-like lesions in 2, 4-dinitrochlorobenzene-induced murine models.Biomol. Ther. (Seoul)202028654254810.4062/biomolther.2020.135 32938818
    [Google Scholar]
  57. Gomez-ChangE. Uribe-EstanislaoG.V. Martinez-MartinezM. Gálvez-MariscalA. RomeroI. Anti-Helicobacter pylori potential of three edible plants known as Quelites in Mexico.J. Med. Food201821111150115710.1089/jmf.2017.0137 30036109
    [Google Scholar]
  58. RussoR. ChandradharaD. De TommasiN. Comparative bioavailability of two diosmin formulations after oral administration to healthy volunteers.Molecules2018239217410.3390/molecules23092174 30158431
    [Google Scholar]
  59. SerraH. MendesT. BronzeM.R. SimplícioA.L. Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.Bioorg. Med. Chem.20081674009401810.1016/j.bmc.2008.01.028 18249545
    [Google Scholar]
  60. ChenX. XuL. GuoS. WangZ. JiangL. WangF. ZhangJ. LiuB. Profiling and comparison of the metabolites of diosmetin and diosmin in rat urine, plasma and feces using UHPLC-LTQ-Orbitrap MSn.J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.20191124587110.1016/j.jchromb.2019.05.030 31177049
    [Google Scholar]
  61. MoriwakiM. KitoK. NakagawaR. KapoorM.P. MatsumiyaY. FukuharaT. KobayashiJ. SatomotoK. YamagataH. KuroiwaY. Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats.Biosci. Biotechnol. Biochem.202387777177610.1093/bbb/zbad051 37133406
    [Google Scholar]
  62. PalmaM.P. Topical microemulsion of diosmetin and uses thereof.WO Patent 2018078412A1,2018
  63. ShanY. LiG. WangZ. LiuJ. CaoW. Recombinant Escherichia coli and method for biosynthesizing diosmetin by using recombinant Escherichia coli.CN Patent 112725256B2023
  64. GuoW. XiaoJ. ZhaoJ. YangX. Semi-synthesis method of diosmetin.CN Patent 109180627B2020
  65. ChenS. XieB. Application of Diosmetin in preparation of medicine for treating non-alcoholic fatty liver disease.CN Patent 116440121A2023
  66. RiverY. ZhaoM. KongD. ChenJ. Culture medium for CART cell culture and application thereof.CN Patent 116790505A92023
  67. LiuY. WangZ. YangB. JiaY. ShiJ. Application of flavonoid compound in preparation of drug-resistant plasmid conjugation transfer inhibition drug.CN Patent 116492330A2023
  68. ZhaoY. ZhengZ. QinL. ZhaoM. XuH. WenlongW. WengL. ZhangX. PengL. Chinese herbal compound preparation for treating ischemic cerebral apoplexy and preparation method thereof.CN Patent 116270943A2023
  69. LaRosaT. Topical antibiotic.US Patent 20230226144A12023
  70. MartinaI. CarolinH. JürgenC. LarsJ. Additive for sunscreens.WO Patent 2023175129A12023
  71. Embedded structure containing honeysuckle, [beta]-glucan, lactobacillus and maslinic acid compound.TWM Patent 642999U2023
  72. KarstenT. AlvinT. SarahB. RosemaryC. EmilyT. KevinH. DouglasH. Methods and compositions for improving plant traits.WO Patent 2018132774A12018
  73. MatthewF. BarryK. GregorM. ShaneM. JulianN. Sugar cane extracts for use in animal feeds.AU Patent 2023201457A12023
  74. Jeong-AiK. Nae-GyuS.K. Composition for stabilizing polyphenolic effective ingredient.KR Patent 20230038154A2023
  75. PiaD. MichaelS. New composition containing liposomes and biosurfactants.WO Patent 2023161179A12023
  76. YaakovN. AaronC. AvnerE. Combination therapy for reducing drug-induced nephrotoxicity, dyslipidemia and hyperglycemia.WO Patent 2022044014A12022
  77. MatthewF. BarryK. GregorM. ShaneM. JulianN. Improving the taste of consumables.AU Patent 2023200820A12023
  78. ChandramouliC. Huey-JingH. LiZ. RuiZ. MihaiA. BoC. Trkb ligand conjugated compounds and uses thereof.WO Patent 2023154896A22023
  79. Freckle removing composition containing bovine placenta tissuederived exosomes and application thereof.CN Patent 116115547A2023
  80. ZengX. LiY. LiJ. CaiJ. HanZ. Method for preparing diosmin by microwave and eutectic reagent synergistic hydrolysis of diosmin.CN Patent 116003364A2023
  81. Plant cleaning powder and preparation method and use method thereof.CN Patent 114774208A2022
  82. FengG. ZhangH. FangJ. WangL. ZhangX. LiuY. ZhengL. PengJ. PengY. YangQ. YangQ. TanH. Application of flavonoid as peroxidase mimic enzyme and wound bacteriostatic composition.CN Patent 114712344A2022
  83. Method for extracting dandelion anti-inflammatory component by ultrasonic-assisted eutectic solvent method.CN patent 114668790B2023
  84. SilS. DasA. SealI. MukherjeeS. RoyS. A toxicological evaluation for safety assessment of ruthenium-based diosmetin complex in rats.Regul. Toxicol. Pharmacol.202313710530310.1016/j.yrtph.2022.105303 36427689
    [Google Scholar]
  85. TerzoS. AmatoA. Magán-FernándezA. CastellinoG. CalviP. ChianettaR. GiglioR.V. PattiA.M. NikolicD. FirenzeA. MulèF. CiaccioM. RizzoM. A nutraceutical containing chlorogenic acid and luteolin improves cardiometabolic parameters in subjects with pre-obesity: a 6-month randomized, double-blind, placebo-controlled study.Nutrients202315246210.3390/nu15020462 36678333
    [Google Scholar]
  86. MeiZ. DuL. LiuX. ChenX. TianH. DengY. ZhangW. Diosmetin alleviated cerebral ischemia/reperfusion injury in vivo and in vitro by inhibiting oxidative stress via the SIRT1/Nrf2 signaling pathway.Food Funct.202213119821210.1039/D1FO02579A 34881386
    [Google Scholar]
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  • Article Type:
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Keyword(s): anti-inflammatory; anticancer; antioxidant; Diosmetin; flavonoids; pharmacokinetic
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