Current Signal Transduction Therapy - Current Issue

BackgroundAKT inhibition presents a promising avenue for cancer treatment strategies. By exploring natural analogues using in silico docking and ADMET profiles, this work aims to design effective anti-cancer therapies shown by binding affinities and pharmacokinetic assessments.Aims and ObjectivesThe aim of this research paper is to utilize in silico ADMET profiling and molecular docking studies to investigate the potential Read More

Parkinson’s Disease (PD) is a common neurodegenerative disease, characterized by motor deficit. Diabetes Mellitus (DM) is a metabolic condition characterized by high glucose levels in the blood. The prevalence of chronic disorders like PD has significantly risen in recent decades. Emerging research has increasingly linked PD with Type 2 Diabetes Mellitus (T2DM) in recent years. Apart from the β-cells of the pancreas, insulin i Read More

Pattern Recognition Receptors (PRRs), particularly Toll-like Receptors (TLRs), are pivotal in the innate immune system for recognizing Pathogen-associated Molecular Patterns (PAMPs) and initiating inflammatory responses. TLRs, characterized by their transmembrane structure, Leucine-rich Repeat (LRR) ectodomain, and Toll/Interleukin-1 Receptor (TIR) domains, detect a diverse range of microbial and endogenous ligands thr Read More

IntroductionNoncommunicable chronic diseases account for the highest number of mortalities across the globe and are responsible as the greatest contributor to medical healthcare expenses. To create new medicines to fight these diseases, we need to fully understand the pathological mechanisms behind them in addition to the usual therapeutic targets. TGF-β has become a promising target for therapy to help a numb Read More

Novo Nordisk has innovated a subcutaneous formulation of semaglutide, branded as Ozempic, which functions as a modified human glucagon-like peptide-1 (GLP-1) analogue. This formulation is tailored to address the treatment needs of individuals diagnosed with type 2 diabetes mellitus (T2DM). By providing a modified version of the naturally occurring hormone GLP-1, Ozempic offers a therapeutic approach that targets Read More