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2000
Volume 15, Issue 1
  • ISSN: 1877-9468
  • E-ISSN: 1877-9476

Abstract

Aims

To study the micellar effect of SDS on the oxidation of glycine by Quinolinium Dichromate (QDC) in perchloric acid medium.

Background

Among the amino acids, glycine plays a major role in multiple metabolic reactions, such as glutathione synthesis and one-carbon metabolism. The oxidation of glycine has received importance because it is the major neurotransmitter inhibitor in the spinal cord and brainstem. In the oxidation process of amino acids, highly toxic chromium (VI) compounds are converted into non-toxic chromium (III) by quinolinium dichromate (QDC) oxidant in an appropriate pH value medium.

Objective

1. To study the catalytic role of anionic surfactant (SDS) on the oxidation of glycine by QDC through micellization, evaluation of critical micelles concentration (CMC) in the presence and absence of glycine and other surface properties along with thermodynamic quantities. 2. Determination of rate constant and order of reaction with respect to QDC, glycine, acid and surfactant which will help to study the kinetics of the reaction 3. Analysis of oxidation product by FT-IR and calculation of activation parameters. 4. Synthesis of oxidant (QDC) and its characterization by UV-Visible spectrophotometer and NMR spectroscopy.

Methods

The reaction was monitored spectrophotometrically at = 440 nm using Systronics Spectrophotometer-166 and 2203. The reaction mixture containing glycine, perchloric acid, SDS and water was taken in a separate flask in a thermostat and the oxidation reaction was started by adding the required amount of oxidant.

Results

First-order kinetics was observed with respect to oxidant, glycine and hydrogen ions. The rate of reaction increased remarkably with an increase in the concentration of surfactant (SDS). The kinetic results show that the ionic strength variation does not have any significant effect on the rate whereas the increase in the dielectric constant of the medium shows a remarkable effect on the rate constant. From stoichiometry study, it was found that 2 moles of oxidant (QDC) consumed 3 moles of glycine to produce aldehyde (Formaldehyde).

Conclusion

The observed negative value of (ΔS) entropy of activation and positive (ΔH) enthalpy of activation suggests a more ordered activated complex formation and highly solvated transition state. The kinetics of the reaction in a perchloric acid medium is found to be accelerated in the presence of surfactant (SDS). The kinetics of the reaction follow pseudo first-order decay of Cr(VI) species (QDC), a unity dependence of rate on glycine and perchloric acid. The oxidation product formaldehyde was identified by FTIR. NMR spectrum analysis of synthesized QDC shows a resemblance with pure QDC.

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A Study of Micellar Catalyses on Oxidation of Glycine by QDC in the Presence of Sodium Dodecyl Sulphate (SDS) in Aqueous Perchloric Acid Medium
Current Physical Chemistry 15, 28 (2025); https://doi.org/10.2174/0118779468311853240726113410
/content/journals/cpc/10.2174/0118779468311853240726113410
/content/journals/cpc/10.2174/0118779468311853240726113410
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  • Article Type:     Research Article
Keyword(s): glycine; Kinetics; mechanism; oxidation; QDC; SDS

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