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2000
Volume 26, Issue 16
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Introduction

Liposomes were extensively used for cosmetics and pharmaceuticals due to their versatility, biocompatibility, and biodegradability, as well as the ability to encapsulate water-soluble and fat-soluble substances. However, some challenges remain unsolved, including poor stability, complex preparation process, limited encapsulation efficiencies (EE%) and drug loading capacity (DLC%).

Methods

We herein prepared universal liquid proliposomes by rotary evaporation method and optimized formulations with different pH, glycerol content, ethanol content and preparation process.

Results

The EE% of water-soluble substances was above 85%, and the maximum DLC% was 37.5%. In 7 different conditions, the optimal formulation of the proliposomes remained stable over 60 days. The excellent stability of proliposomes and nicotinamide liposomes and their essence, when applied to cosmetic formulations, was confirmed by the Turbiscan stability analyzer.

Conclusion

The proposed universal liquid proliposomes can form liposomes encapsulating a variety of water-soluble substances rapidly, making them an accessible and versatile tool for improving the stability and applicability of water-soluble raw materials.

© 2025 Bentham Science Publishers
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Preparation and Characterization of Universal Liquid Proliposomes Encapsulating Water-soluble Efficacious Substances
Current Pharmaceutical Biotechnology 26, 2604 (2025); https://doi.org/10.2174/0113892010328982241004064135
/content/journals/cpb/10.2174/0113892010328982241004064135
/content/journals/cpb/10.2174/0113892010328982241004064135
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  • Article Type:     Research Article
Keyword(s): drug loading capacity; encapsulation efficiency; Liquid proliposomes; stability; turbiscan stability; water-soluble functional substances

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