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2000
Volume 26, Issue 16
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Introduction

Docetaxel (DTX) is a chemotherapeutic drug that has high toxicity and low bioavailability. To solve these problems, PLGA nanoparticles (NPs) were loaded with DTX and coated with mucoadhesive polymers; chitosan (CS), carboxymethyl chitosan (CMCS), or glycol chitosan (GCS). The NPs were characterized for size, charge, and polydispersity.

Methods

The particles were explored using SEM, FTIR, DSC, and XRD. studies were performed to evaluate the mucoadhesive properties of the NPs and the drug release.

Results

The results validated the successful formation of spherical and monodispersed DTX NPs. The coated NPs exhibited highly positive charges, reaching +44.30±0.21 mV, whereas the uncoated NPs were almost neutral. The formulations demonstrated excellent encapsulation efficiency (>98%) and loading capacity (>45%). All polymers used in the coating process enhanced the mucoadhesive properties of PLGA NPs and sustained DTX release. Both the mucoadhesiveness and release were related to the used coating polymer and its concentration. The formulations were stable for up to three months in the refrigerator.

Conclusion

In conclusion, loading DTX in PLGA NPs and coating them with CS, CMCS, or GCS provides a promising strategy to increase the NPs' residence time on mucosal surfaces, which is expected to decrease the required dose of DTX and reduce its side effects.

© 2025 Bentham Science Publishers
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Poly(Lactic-co-glycolic Acid Nanoparticles Loaded with Docetaxel and Coated with Chitosan, Carboxymethyl Chitosan, or Glycol Chitosan
Current Pharmaceutical Biotechnology 26, 2590 (2025); https://doi.org/10.2174/0113892010335722240923110808
/content/journals/cpb/10.2174/0113892010335722240923110808
/content/journals/cpb/10.2174/0113892010335722240923110808
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  • Article Type:     Research Article
Keyword(s): carboxymethyl chitosan; chitosan; Docetaxel; glycol chitosan; mucoadhesive; nanoparticles

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