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2000
Volume 29, Issue 19
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Carbazoloquinones possess a unique structural characteristic commonly found in natural compounds. Precisely, these molecules have been integral to traditional medicine, addressing various health concerns such as malaria, cancer, and neuronal protection. This review centers on the occurrence, biological activity, and asymmetric synthesis of bioactive carbazole-3,4-quinone alkaloids, which demonstrate notable properties like neuronal cell protection and free radical scavenging. To date, this is the first exclusive review focusing on carbazole-3,4-quinones. We delve into the asymmetric and enantioselective synthetic methods used to synthesise three families of naturally occurring carbazole-3,4-quinone molecules: carbazoquinocins, (±)-carquinostatins, and (±)-lavanduquinocins. Despite the existence of efficient synthetic strategies for some of these compounds, there remain challenges and opportunities for developing new methods for carbazole-3,4-quinone natural products.

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/content/journals/coc/10.2174/0113852728359677250402131159
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A Review on the Occurrence and Synthetic Strategies of Natural Carbazole-3,4-Quinones: Racemic and Enantioselective Approaches
Current Organic Chemistry 29, 1472 (2025); https://doi.org/10.2174/0113852728359677250402131159
/content/journals/coc/10.2174/0113852728359677250402131159
/content/journals/coc/10.2174/0113852728359677250402131159
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  • Article Type:     Review Article
Keyword(s): Carbazole; carbazole-3,4-quinone; malaria; natural product; neuronal cell; quinone

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