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2000
Volume 29, Issue 13
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

To improve the activity of isatin-1,2,3-triazole hybrids as anti-cancer agents, new derivatives of isatin-thiosemicarbazone-1,2,3-triazoles were designed and synthesized the condensation of isatin-1,2,3-triazole hybrids with thiosemicarbazide. Spectral and elemental analysis confirmed the structure of the prepared derivatives . Also, as anticancer agents, the latter derivatives were screened against three human cancerous cell lines: human lung fibroblast (WI38), colorectal carcinoma colon cancer (HCT-116), and mammary gland breast cancer (MCF-7). , a standard control, was used to compare viable cell percentages and IC values. In general, derivatives and revealed a higher potency against the three human cancerous cell lines. Finally, the molecular descriptors of compounds and were correlated with their observed cytotoxicity.

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Synthesis, Characterization, and Molecular Docking of Novel Isatin-thiosemicarbazone Containing 1,2,3-triazole Derivatives as Potential Anti-cancer Agents
Current Organic Chemistry 29, 1050 (2025); https://doi.org/10.2174/0113852728332494240919044627
/content/journals/coc/10.2174/0113852728332494240919044627
/content/journals/coc/10.2174/0113852728332494240919044627
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  • Article Type:     Research Article
Keyword(s): 1,2,3-triazole derivatives; anti-cancer agents; cytotoxicity; docking of molecules; Isatin; thiosemicarbazone

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