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2000
Volume 6, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

This review aims to investigate and evaluate the existing scientific research on the potential of nutraceuticals in preventing or curing diabetes. It involves summarizing and analyzing studies, clinical trials, and data related to the effects of specific nutraceuticals on diabetes prevention and treatment.

Moreover, it examines the potential of various nutraceuticals in the prevention and treatment of diabetes, focusing on evidence-based studies that demonstrate their efficacy, safety, and potential to improve overall health outcomes for individuals with diabetes or at risk for developing the condition.

Synthetic medication treatment solutions do not suit the needs of patients. The notion of nutraceuticals was born out of a survey conducted in the United Kingdom, Germany, and France, which found that consumers value nutrition more than exercise or inherited factors in achieving excellent health. Nutraceuticals, which give health advantages and are an alternative to contemporary medicine, have gained popularity in recent years. Herbal medications provide a better therapeutic promise with fewer side effects than conventional therapeutic needs for treating diabetes. Nutraceuticals encompass a wide range of substances, including botanicals, vitamins, antioxidants, minerals, amino acids, and fatty acids. Incorporating them into your diet or supplement routine can provide a variety of health benefits. While they may have broad applications, their effects are often more targeted compared to traditional pharmaceutical drugs, and they are commonly used as complementary or alternative therapies in conjunction with conventional medical treatments.

Nutraceuticals are nutritionally valuable dietary supplements. Many of the nutrients mentioned, including botanicals, vitamins, antioxidants, minerals, amino acids, and fatty acids, have demonstrated clinical and pharmacological efficacy in various aspects of health, including their potential anti-diabetic effects.

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References

  1. BandayM.Z. SameerA.S. NissarS. Pathophysiology of diabetes: An overview.Avicenna J. Med.202010417418810.4103/ajm.ajm_53_2033437689
    [Google Scholar]
  2. National diabetes statistics report2017Available from: www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf
  3. NakshineV.S. JogdandS.D. A comprehensive review of gestational diabetes mellitus: Impacts on maternal health, Fetal development, Childhood outcomes, and long-term treatment strategies.Cureus20231510e4750010.7759/cureus.4750038021940
    [Google Scholar]
  4. SpeightJ. ConnJ. DunningT. SkinnerT.C. Diabetes australia position statement. A new language for diabetes: Improving communications with and about people with diabetes.Diabetes Res. Clin. Pract.201297342543110.1016/j.diabres.2012.03.01522513346
    [Google Scholar]
  5. RamaaC. ShirodeA. MundadaA. KadamV. Nutraceuticals--An emerging era in the treatment and prevention of cardiovascular diseases.Curr. Pharm. Biotechnol.200671152310.2174/13892010677578964716472130
    [Google Scholar]
  6. ElliottR. OngT.J. Science, medicine, and the future: Nutritional genomics.BMJ200232473511438144210.1136/bmj.324.7351.143812065270
    [Google Scholar]
  7. BiesalskiH.K. KramerK. HoppeP.P. PackerL. Nutraceuticals: the link between nutrition and medicine.Nutraceuticals in health and disease prevention.Marcel Dekker IncNew York2001151742CRC Press10.1201/9780203908174.ch1
    [Google Scholar]
  8. RossS. Functional foods: The food and drug administration perspective.Am. J. Clin. Nutr.2000716Suppl.1735S1738S10.1093/ajcn/71.6.1735S10837331
    [Google Scholar]
  9. WilcoxG. Insulin and insulin resistance.Clin. Biochem. Rev.2005262193916278749
    [Google Scholar]
  10. Diaz-SantanaM.V. O’BrienK.M. ParkY.M.M. SandlerD.P. WeinbergC.R. Persistence of risk for type 2 diabetes after gestational diabetes mellitus.Diabetes Care202245486487010.2337/dc21‑143035104325
    [Google Scholar]
  11. KhanR. ChuaZ. TanJ. YangY. LiaoZ. ZhaoY. From pre-diabetes to diabetes: Diagnosis, treatments and translational research.Medicina201955954610.3390/medicina5509054631470636
    [Google Scholar]
  12. AhmedA.M. History of diabetes mellitus.Saudi Med. J.200223437337811953758
    [Google Scholar]
  13. LakhtakiaR. The history of diabetes mellitus.Sultan Qaboos Univ. Med. J.201313336837010.12816/0003257
    [Google Scholar]
  14. NasriH. BaradaranA. ShirzadH. Rafieian-KopaeiM. New concepts in nutraceuticals as alternative for pharmaceuticals.Int. J. Prev. Med.20145121487149925709784
    [Google Scholar]
  15. HathcockJ. Dietary supplements: How they are used and regulated.J. Nutr.200113131114S1117S10.1093/jn/131.3.1114S11238828
    [Google Scholar]
  16. Afkhami-ArdekaniM. Shojaoddiny-ArdekaniA. Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients.Indian J. Med. Res.2007126547147418160753
    [Google Scholar]
  17. JeannetteM. Wylie-RosettJ. The role of dietary proteins among persons with diabetes.Curr. Atheroscler. Rep.201310.1007/s11883‑013‑0348‑223881544
    [Google Scholar]
  18. CoenzymeD.M. Coenzyme Q10 supplementation for diabetes and its complications: An overview.BJDVD20177410.15277/bjd.2017.149
    [Google Scholar]
  19. ChenH. KarneR.J. HallG. CampiaU. PanzaJ.A. CannonR.O.III WangY. KatzA. LevineM. QuonM.J. High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance.Am. J. Physiol. Heart Circ. Physiol.20062901H137H14510.1152/ajpheart.00768.200516126809
    [Google Scholar]
  20. SantaguidaP.L. BalionC. HuntD. MorrisonK. GersteinH. RainaP. BookerL. YazdiH. Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose.Evid. Rep. Technol. Assess.200512812811116194123
    [Google Scholar]
  21. AmarteifioJ.O. David MunthaliS.K. KarikariS.K. MorakeT.K. The composition of pigeon peas (Cajanus cajan (L.) Millsp.) grown in Botswana.200257217317710.1023/A:1015248326920
    [Google Scholar]
  22. BhartiS.K. KrishnanS. KumarA. KumarA. Awanish kumar antidiabetic phytoconstituents and their mode of action on metabolic pathways2018938110010.1177/204201881875501929492244
    [Google Scholar]
  23. KumarP. BhargavaS. AgarwalP. GargA. KhoslaA. Association of serum magnesium with type 2 diabetes mellitus and diabetic retinopathy.J. Family Med. Prim. Care2019851671167710.4103/jfmpc.jfmpc_83_1931198735
    [Google Scholar]
  24. PandeyK.B. RizviS.I. Plant polyphenols as dietary antioxidants in human health and disease.Oxid. Med. Cell. Longev.20092527027810.4161/oxim.2.5.949820716914
    [Google Scholar]
  25. ElbadawyA.M. Abd ElmoniemR.O. ElsayedA.M. Alpha lipoic acid and diabetes mellitus: Potential effects on peripheral neuropathy and different metabolic parameters.Alex. J. Med.202157111312010.1080/20905068.2021.1907961
    [Google Scholar]
  26. JoséL. GómezM. Vanadium compounds for the treatment of human diabetes mellitus: A scientific curiosity? A review of thirty years of research.Food. Chem. Toxicol.201613714110.1016/j.fct.2016.07.00527417449
    [Google Scholar]
  27. RautA. BichileL. ChopraA. PatwardhanB. VaidyaA. Comparative study of amrutbhallataka and glucosamine sulphate in osteoarthritis: Six months open label randomized controlled clinical trial.J. Ayurveda Integr. Med.20134422923610.4103/0975‑9476.12370824459390
    [Google Scholar]
  28. ChopraA. SalujaM. TilluG. VenugopalanA. SarmukaddamS. RautA.K. BichileL. NarsimuluG. HandaR. PatwardhanB. A randomized controlled exploratory evaluation of standardized ayurvedic formulations in symptomatic osteoarthritis knees: A government of India NMITLI Project.Evid. Based Complement. Alternat. Med.20112011172429110.1155/2011/72429120981160
    [Google Scholar]
  29. RoozbehN. DarvishL. AbdiF. Hypoglycemic effects of Acacia nilotica in type II diabetes: A research proposal.BMC Res. Notes201710133110.1186/s13104‑017‑2646‑128747209
    [Google Scholar]
  30. KamalakannanD. BaskarV. BartonD.M. AbduT.A.M. Diabetic ketoacidosis in pregnancy.Postgrad. Med. J.20037993445445710.1136/pmj.79.934.45412954957
    [Google Scholar]
  31. MathewP.T. AugustiK.T. Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes. I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis.Indian J. Biochem. Biophys.19731032092124792931
    [Google Scholar]
  32. Arellano-BuendíaA.S. Castañeda-LaraL.G. Loredo-MendozaM.L. García-ArroyoF.E. Rojas-MoralesP. Argüello-GarcíaR. Juárez-RojasJ.G. TapiaE. Pedraza-ChaverriJ. Sánchez-LozadaL.G. Osorio-AlonsoH. Effects of allicin on pathophysiological mechanisms during the progression of nephropathy associated to diabetes.Antioxidants2020911113410.3390/antiox911113433203103
    [Google Scholar]
  33. AjabnoorM.A. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice.J. Ethnopharmacol.199028221522010.1016/0378‑8741(90)90031‑N2109811
    [Google Scholar]
  34. ShirwaikarA. RajendranK. Dinesh KumarC. BodlaR. Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin–nicotinamide type 2 diabetic rats.J. Ethnopharmacol.200491117117510.1016/j.jep.2003.12.01715036485
    [Google Scholar]
  35. ModakM. DixitP. LondheJ. GhaskadbiS. DevasagayamT.P.A. Indian herbs and herbal drugs used for the treatment of diabetes.J. Clin. Biochem. Nutr.200740316317310.3164/jcbn.40.16318398493
    [Google Scholar]
  36. SinghU. KochharA. SinghS. Blood glucose lowering potential of some herbal plants.J. Med. Plant Res.201151946914695
    [Google Scholar]
  37. ReyesB.A.S. BautistaN.D. TanquilutN.C. AnunciadoR.V. LeungA.B. SanchezG.C. MagtotoR.L. CastronuevoP. TsukamuraH. MaedaK-I. Anti-diabetic potentials of momordica charantia and andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats.J. Ethnopharmacol.20061051-219620010.1016/j.jep.2005.10.01816298503
    [Google Scholar]
  38. YoshikawaM. MurakamiT. KadoyaM. MatsudaH. MuraokaO. YamaharaJ. MurakamiN. Medicinal foodstuff. III. Sugar beet. (1): Hypoglycemic oleanolic acid oligoglycosides, betavulgarosides I, II, III, and IV, from the root of Beta vulgaris L. (Chenopodiaceae).Chem. Pharm. Bull.19964461212121710.1248/cpb.44.12128814952
    [Google Scholar]
  39. GroverJ.K. YadavS. VatsV. Hypoglycemic and antihyperglycemic effect of Brassicajuncea diet and their effect on hepatic glycogen content and the key enzymes of carbohydrate metabolism.Mol. Cell. Biochem.20022411/29510110.1023/A:102081470911812482030
    [Google Scholar]
  40. LathaM. PariL. Antihyperglycaemic effect of Cassia auriculata in experimental diabetes and its effects on key metabolic enzymes involved in carbohydrate metabolism.Clin. Exp. Pharmacol. Physiol.2003301-2384310.1046/j.1440‑1681.2003.03785.x12542451
    [Google Scholar]
  41. PariL. Amarnath SatheeshM. Antidiabetic effect of Boerhavia diffusa: Effect on serum and tissue lipids in experimental diabetes.J. Med. Food20047447247610.1089/jmf.2004.7.47215671692
    [Google Scholar]
  42. ZhouQ. LeiX. FuS. LiZ. ChenY. LongC. LiS. ChenQ. Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review.Front. Physiol.20221396058010.3389/fphys.2022.96058036505061
    [Google Scholar]
  43. Abdel-HassanI.A. Abdel-BarryJ.A. MohammedaS.T. 2000The hypoglycaemic and antihyperglycaemic effect of Citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits.711-232533010.1016/S0378‑8741(99)00215‑9
    [Google Scholar]
  44. AmalrajT. IgnacimuthuS. Evaluation of the hypoglycemic effect of Cajanus cajan (seeds) in mice.Indian J. Exp. Biol.1998361032103310356965
    [Google Scholar]
  45. NammiS. BoiniM.K. LodagalaS.D. BeharaR.B.S. The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits.BMC Complement. Altern. Med.200331410.1186/1472‑6882‑3‑412950994
    [Google Scholar]
  46. SabuM.C. SmithaK. KuttanR. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes.J. Ethnopharmacol.2002831-210911610.1016/S0378‑8741(02)00217‑912413715
    [Google Scholar]
  47. LakshmiE. Optimization of product incorporating indian blackberry (Syzygium cumini) seed flour: A diabetic study.Asian J. Pharm. Clin. Res.201811319110.22159/ajpcr.2018.v11i3.2326512413715
    [Google Scholar]
  48. JacobBindu NarendhirakannanR.T. Role of medicinal plants in the management of diabetes mellitus: A review.201991410.1007/s13205‑018‑1528‑030555770
    [Google Scholar]
  49. AkhtarN. AkramM. DaniyalM. AhmadS. Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats.Int. J. Immunopathol. Pharmacol.201832205873841881467810.1177/205873841881467830477357
    [Google Scholar]
  50. ChenS. XiM. GaoF. LiM. DongT. GengZ. LiuC. HuangF. WangJ. LiX. WeiP. MiaoF. Evaluation of mulberry leaves’ hypoglycemic properties and hypoglycemic mechanisms.Front. Pharmacol.202314104530910.3389/fphar.2023.104530937089923
    [Google Scholar]
  51. KhanB.A. AbrahamA. LeelammaS. Hypoglycemic action of Murraya koenigii (curry leaf) and Brassica juncea (mustard): Mechanism of action.Indian J. Biochem. Biophys.19953221061087642200
    [Google Scholar]
  52. GuptaR. BajpaiK.G. JohriS. SaxenaA.M. An overview of indian novel traditional medicinal plants with anti-diabetic potentials.Afr. J. Tradit. Complement. Altern. Med.20075111720162049
    [Google Scholar]
  53. HuangT.H.W. PengG. KotaB.P. LiG.Q. YamaharaJ. RoufogalisB.D. LiY. Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: Role of lowering circulating lipids.Br. J. Pharmacol.2005145676777410.1038/sj.bjp.070624515880139
    [Google Scholar]
  54. ChandramohanG. IgnacimuthuS. PugalendiK.V. A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats.Eur. J. Pharmacol.20085901-343744310.1016/j.ejphar.2008.02.08218635165
    [Google Scholar]
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  • Article Type:
    Review Article
Keyword(s): CoQ10; diabetes; insulin; metabolic syndrome; Nutraceuticals; synthetic medication
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