Current Nutraceuticals - Online First
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Harnessing Nature's Arsenal: Phytoconstituents Targeting Mediators Involved in Pathogenesis of Asthma
Authors: Sahil Hussain, Badruddeen, Mohd Mursal, Juber Akhtar, Mohammad Irfan Khan and Mohammad AhmadAvailable online: 03 December 2024More LessAsthma is a persistent respiratory disorder characterized by inflammation and constriction of the air passages, resulting in recurrent symptoms, including difficulty breathing, wheezing, coughing, and a sensation of tightness in the chest. It requires ongoing management through medications and lifestyle adjustments. The use of natural bioactive compounds in asthma management is on the rise. Researchers are increasingly exploring the potential of compounds derived from plants and herbs, such as quercetin, resveratrol, and Boswellia extracts, for their anti-inflammatory and bronchodilator properties. Compounds like quercetin and resveratrol are known to reduce inflammation by inhibiting enzymes like PDE4 and LOX-5, which play key roles in asthma-related inflammation. They can additionally regulate immune reactions by inhibiting the secretion of pro-inflammatory cytokines like “IL-6, IL-5, and IL-4”. Additionally, some compounds, like those found in Boswellia extracts, inhibit NF-κB activation, which further reduces the production of inflammatory mediators. These natural remedies offer a promising avenue for complementing traditional asthma treatments, potentially providing relief from symptoms and reducing the reliance on synthetic drugs. The aim of this review is to offer an outline of well-researched plant-derived phytoconstituents that influence cellular activity to control inflammatory mediators associated with asthma. Nevertheless, additional high-quality research is essential to validate the clinical effectiveness of plant-based treatments for asthma.
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The Potential Role of Herbal Plants in the Management of Depression: Pre-Clinical and Clinical Evidence
Authors: Arzoo Pannu, Ramesh K. Goyal and Kalicharan SharmaAvailable online: 17 October 2024More LessDepression, a debilitating mental health disorder affecting millions worldwide, continues to challenge the medical community. While several pharmacological interventions exist, their efficacy and side effects often warrant the exploration of alternative treatments. Natural products derived from plants have gained attention for their potential antidepressant properties in preclinical studies. This comprehensive review examines the antidepressant activity of various plant-based extracts through preclinical investigations and explores the underlying mechanisms of action. Our review systematically analyzes the literature, encompassing a wide range of plants. We present evidence from pre-clinical and clinical studies, highlighting the behavioural and neurochemical changes induced by these plant-derived compounds. Furthermore, we delve into the potential mechanisms of action, encompassing modulation of neurotransmitters, anti-inflammatory effects, neurogenesis promotion, and antioxidant properties. The reviewed studies suggest that numerous plants possess promising antidepressant properties, potentially offering novel therapeutic avenues. However, the variability in methodologies and the need for further clinical validation underscore the complexity of translating preclinical findings into effective treatments. This review serves as a valuable resource for researchers and clinicians alike, shedding light on the current state of knowledge regarding plants with antidepressant potential and their underlying mechanisms of action, paving the way for future investigations and therapeutic developments in the field of depression management.
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