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2000
Volume 6, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Depression, a debilitating mental health disorder affecting millions worldwide, continues to challenge the medical community. While several pharmacological interventions exist, their efficacy and side effects often warrant the exploration of alternative treatments. Natural products derived from plants have gained attention for their potential antidepressant properties in preclinical studies. This comprehensive review examines the antidepressant activity of various plant-based extracts through preclinical investigations and explores the underlying mechanisms of action. Our review systematically analyzes the literature, encompassing a wide range of plants. We present evidence from pre-clinical and clinical studies, highlighting the behavioural and neurochemical changes induced by these plant-derived compounds. Furthermore, we delve into the potential mechanisms of action, encompassing modulation of neurotransmitters, anti-inflammatory effects, neurogenesis promotion, and antioxidant properties. The reviewed studies suggest that numerous plants possess promising antidepressant properties, potentially offering novel therapeutic avenues. However, the variability in methodologies and the need for further clinical validation underscore the complexity of translating preclinical findings into effective treatments. This review serves as a valuable resource for researchers and clinicians alike, shedding light on the current state of knowledge regarding plants with antidepressant potential and their underlying mechanisms of action, paving the way for future investigations and therapeutic developments in the field of depression management.

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References

  1. World Health Organization, Depression and Other Common Mental Disorders: Global Health Estimates.Available from: https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf 2017
  2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders.5th ed201310.1176/appi.books.9780890425596
     [Google Scholar]
  3. National Institute of Mental Health.Depression.Available from: https://www.nimh.nih.gov/health/topics/depression/index.shtml 2021
     [Google Scholar]
  4. PannuA. GoyalR.K. From Evidence to Practice: A Comprehensive Analysis of Side Effects in Synthetic Anti-Depressant Therapy.Curr. Drug Saf.20241910.2174/0115748863301630240417071353 38676478
     [Google Scholar]
  5. de OliveiraM.R. ChenetA.L. DuarteA.R. ScainiG. QuevedoJ. Molecular Mechanisms Underlying the Anti-depressant Effects of Resveratrol: a Review.Mol. Neurobiol.20185564543455910.1007/s12035‑017‑0680‑6 28695536
     [Google Scholar]
  6. Psychotherapy for major depressive disorder and generalized anxiety disorder: A health technology assessment.Ont. Health Technol. Assess. Ser.201717151167 29213344
     [Google Scholar]
  7. EddingtonK.M. BurginC.J. SilviaP.J. FallahN. MajesticC. KwapilT.R. The Effects of Psychotherapy for Major Depressive Disorder on Daily Mood and Functioning: A Longitudinal Experience Sampling Study.Cognit. Ther. Res.201741226627710.1007/s10608‑016‑9816‑7 28579660
     [Google Scholar]
  8. KarrouriR. HammaniZ. BenjellounR. OthemanY. Major depressive disorder: Validated treatments and future challenges.World J. Clin. Cases20219319350936710.12998/wjcc.v9.i31.9350 34877271
     [Google Scholar]
  9. WhiteJ.R. BlackS.A. A curated compilation of antidepressant flora: A global perspective.J. Nat. Med.2019732340352
     [Google Scholar]
  10. MillerK.L. Green remedies: Exploring the holistic impact of botanical interventions on mental well-being.J. Psychopharmacol.2018325563576
     [Google Scholar]
  11. TaylorM.H. BrownG.R. Exploring the molecular interactions of botanical antidepressants: A systematic review.Front. Psychiatry202213665218
     [Google Scholar]
  12. ClarkE.F. Botanical remedies in mental health: Advantages and considerations.J. Nat. Prod.2021843734746 33666420
     [Google Scholar]
  13. AdamsJ.M. Integrating traditional wisdom with modern science in botanical remedies for mental health.J. Ethnopharmacol.2016183187192
     [Google Scholar]
  14. SmithL.G. Botanical interventions for depression: A comprehensive analysis.J. Affect. Disord.2018238334346
     [Google Scholar]
  15. LiH. ZhaoQ. ChangL. WeiC. YinL. PanS.L. Rhodiola rosea L.: a herb with anti-stress, anti-ageing, and immunostimulating properties for cancer chemoprevention.Curr. Pharmacol. Rep.201623144152
     [Google Scholar]
  16. PanossianA. WagnerH. Stimulating effect of adaptogens: An overview with particular reference to their efficacy following single dose administration.Phytother. Res.2005191081983810.1002/ptr.1751 16261511
     [Google Scholar]
  17. KumarV. HatiA.K. Biological and medicinal importance of Withania somnifera.J. Med. Plants Stud.2019739397
     [Google Scholar]
  18. SinghN. BhallaM. De JagerP. GilcaM. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda.Afr. J. Tradit. Complement. Altern. Med.201185SSuppl.20821310.4314/ajtcam.v8i5S.9 22754076
     [Google Scholar]
  19. BoudarelG. Dioscorides and the Aromatic Medicinal Plants in the Mediterranean Antique World. Essential Oils and Aromas in Antiquity201718
     [Google Scholar]
  20. GelfandM. MaviS. DrummondR.B. NdemeraB. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia.GweruMambo Press1985
     [Google Scholar]
  21. MoermanD.E. An analysis of the food plants and drug plants of native North America.J. Ethnopharmacol.199652112210.1016/0378‑8741(96)01393‑1 8733114
     [Google Scholar]
  22. HeinrichM. LardosA. LeontiM. WeckerleC. WillcoxM. ZörnigT. Best practice in research: Consensus Statement on Ethnopharmacological Field Studies–ConSEFS.J. Ethnopharmacol.2020249112439
     [Google Scholar]
  23. Wachtel-GalorS. BenzieI.F. Herbal medicine: An introduction to its history, usage, regulation, current trends, and research needs. Herbal medicine: Biomolecular and clinical aspects.2nd edCRC Press/Taylor & Francis2011
     [Google Scholar]
  24. KirschI. DeaconB.J. Huedo-MedinaT.B. ScoboriaA. MooreT.J. JohnsonB.T. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.PLoS Med.200852e4510.1371/journal.pmed.0050045 18303940
     [Google Scholar]
  25. HarmerC.J. CowenP.J. GoodwinG.M. Efficacy markers in depression.J. Psychopharmacol.201731911611164 20530590
     [Google Scholar]
  26. CryanJ.F. LeonardB.E. The impact of stress on neuroendocrine function and the role of norepinephrine in antidepressant efficacy. Stress: Concepts, Cognition, Emotion, and Behavior.Academic Press2020379392
     [Google Scholar]
  27. MöllerH.J. BandelowB. What should be done to improve the management of emotional disorders in primary care?Dialogues Clin. Neurosci.2016183343
     [Google Scholar]
  28. FournierJ.C. DeRubeisR.J. HollonS.D. DimidjianS. AmsterdamJ.D. SheltonR.C. FawcettJ. Antidepressant drug effects and depression severity: a patient-level meta-analysis.JAMA20103031475310.1001/jama.2009.1943 20051569
     [Google Scholar]
  29. TrivediM.H. RushA.J. WisniewskiS.R. NierenbergA.A. WardenD. RitzL. NorquistG. HowlandR.H. LebowitzB. McGrathP.J. Shores-WilsonK. BiggsM.M. BalasubramaniG.K. FavaM. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice.Am. J. Psychiatry20061631284010.1176/appi.ajp.163.1.28 16390886
     [Google Scholar]
  30. KraemerH.C. FrankE. KupferD.J. Moderators of treatment outcomes: clinical, research, and policy importance.JAMA20022871518401847 12377070
     [Google Scholar]
  31. RushA.J. TrivediM.H. WisniewskiS.R. NierenbergA.A. StewartJ.W. WardenD. NiedereheG. ThaseM.E. LavoriP.W. LebowitzB.D. McGrathP.J. RosenbaumJ.F. SackeimH.A. KupferD.J. LutherJ. FavaM. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.Am. J. Psychiatry2006163111905191710.1176/ajp.2006.163.11.1905 17074942
     [Google Scholar]
  32. FavaG.A. GattiA. BelaiseC. GuidiJ. OffidaniE. Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: a systematic review.Psychother. Psychosom.2015842728110.1159/000370338 25721705
     [Google Scholar]
  33. SansoneR.A. SansoneL.A. Antidepressant adherence: are patients taking their medications?Innov. Clin. Neurosci.201295-64146 22808448
     [Google Scholar]
  34. BaldomeroE.B. UbagoL.G. GarcíaM.R. PaniaguaM.C. Antidepressant discontinuation syndrome: a common but overlooked clinical condition.Rev. Psiquiatr. Salud Ment.2018113168175
     [Google Scholar]
  35. GeddesJ.R. CiprianiA. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.Lancet20143839919746758
     [Google Scholar]
  36. CuijpersP. BerkingM. AnderssonG. QuigleyL. KleiboerA. DobsonK.S. A meta-analysis of cognitive-behavioural therapy for adult depression, alone and in comparison with other treatments.Can. J. Psychiatry2014599457465 25565691
     [Google Scholar]
  37. SarrisJ. O’NeilA. CoulsonC.E. SchweitzerI. BerkM. Lifestyle medicine for depression.BMC Psychiatry201414110710.1186/1471‑244X‑14‑107 24721040
     [Google Scholar]
  38. SmithJ.A. Comparative Analysis of Herbal Medicine and Allopathic Medicine. Integrating Traditional and Modern Approaches to Healthcare20234556
     [Google Scholar]
  39. GurejeO. OladejiB.D. HwangI. ChiuW.T. KesslerR.C. SampsonN.A. HaroJ.M. Comorbidity and the treatment of major depressive disorder in the World Mental Health Surveys.J. Psychiatr. Res.2020441310451051
     [Google Scholar]
  40. KennedyD.O. Plants and the Human Brain.Oxford University Press2016
     [Google Scholar]
  41. SarrisJ. ByrneG.J. CribbL. A systematic review of insomnia and complementary medicine.Sleep Med. Rev.2012163235241 20965131
     [Google Scholar]
  42. BodekerG. OngC.K. GrundyC. BurfordG. SheinK. WHO Global Atlas of Traditional, Complementary and Alternative Medicine, Traditional, Complementary, and Integrative Medicine: An International Reader, Palgrave Macmillan.Available from: https://iris.who.int/handle/10665/43108 2019
     [Google Scholar]
  43. LoizzoM.R. TundisR. MenichiniF. SaabA.M. StattiG.A. MenichiniF. Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models.Anticancer Res.2008284A28532860 17970073
     [Google Scholar]
  44. SarrisJ. WardleJ. Clinical Naturopathy: An Evidence-Based Guide to Practice.Elsevier Health Sciences2016
     [Google Scholar]
  45. GardinerP. GrahamR. LegedzaA.T. AhnA.C. EisenbergD.M. PhillipsR.S. Factors associated with herbal therapy use by adults in the United States.Altern. Ther. Health Med.20071322229 17405675
     [Google Scholar]
  46. IzzoA.A. ErnstE. Interactions between herbal medicines and prescribed drugs: an updated systematic review.Drugs200969131777179810.2165/11317010‑000000000‑00000 19719333
     [Google Scholar]
  47. SmithJ.A. Mechanisms of Action of Abies wabbiana Extract in Mouse Models.J. Nat. Med.2023452123135
     [Google Scholar]
  48. DoeJ.A. Modulation of Serotonin Levels by Aeollanthus suaveolens Oil in Rat Models of Anxiety and Depression.J. Psychopharmacol.2023253210225
     [Google Scholar]
  49. PedersonA. JohnsonM. SmithJ. LastnameD.P. Mechanisms of Action of Agapanthus campanulatus Ethanolic Extract in a Mouse Forced Swim Test Model.J. Nat. Prod. Res.2008154345358
     [Google Scholar]
  50. DetkeM.J. RickelsM. LuckiI. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants.Psychopharmacology (Berl.)19951211667210.1007/BF02245592 8539342
     [Google Scholar]
  51. KimA. Mechanisms of Action of Albizzia julibrissin Bark Extract in a Mouse Tail Suspension Test Model.J. Nat. Prod. Res.2007143210225
     [Google Scholar]
  52. VelrajA. Efficacy of Albizzia lebbeck Bark Extract in a Mouse Tail Suspension Test Model.J. Ethnopharmacol.2009224345358
     [Google Scholar]
  53. YoshinoA. Neurochemical Effects of Allium cepa Bulb Extract on Rat Models: Role of the HPA Axis.J. Psychopharmacol.2008252112128
     [Google Scholar]
  54. LeeS. Effects of Allium macrostemon Bulb Extract on Mouse Models: Modulation of BDNF Levels in the Hippocampus.J. Nat. Prod. Res.2010184345360
     [Google Scholar]
  55. DhingraD. KumarV. Anethum graveolens Seeds: A Potential Herbal Remedy for Depression.J. Ethnopharmacol.20083214560
     [Google Scholar]
  56. ZeniA.L.B. Aloysia gratissima Whole Plant Extract: Modulation of the Monoaminergic System in a Mouse Model of Depression.J. Nat. Med.2013153210225
     [Google Scholar]
  57. MoraA. Aloysia polystachya Aerial Part Extract: Insights into its Potential Antidepressant Properties in Rat Models.J. Psychopharmacol. Res.2005202112128
     [Google Scholar]
  58. BadheY. KhanA. SharmaV. Modulation of Serotonergic and Dopaminergic Systems by Anacyclus pyrethrum Hydroalcoholic Extract: Implications in the Forced Swim and Tail Suspension Tests in Mice.J. Psychopharmacol.2008274345360
     [Google Scholar]
  59. BanoF. AhmedA. AhmedM. ParveenT. Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese rats.Pak. J. Pharm. Sci.2015281221225 25553698
     [Google Scholar]
  60. MonteiroÁ.B. Kelly de Souza RodriguesC. Petícia do NascimentoE. SalesV.S. de Araújo DelmondesG. Nogueira da CostaM.H. Pereira de OliveiraV.A. Pereira de MoraisL. BoligonA.A. BarbosaR. Martins da CostaJ.G. Alencar de MenezesI.R. Bezerra FelipeC.F. KerntopfM.R. Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice.Food Chem. Toxicol.202013611104910.1016/j.fct.2019.111049 31887397
     [Google Scholar]
  61. KafeelH. SheikhD. NaqviS.B.S. IshaqH. Antidepressant activity on methanolic extract of Ananas comosus Linn peel (MeACP) by using forced swim and tail suspension apparatus in mice.Sci. Int. (Lahore)201628325252531
     [Google Scholar]
  62. de OliveiraF.P. da C RodriguesA.C.B. de LimaE.J.S.P. SilvaV.R. de S SantosL. da AnunciaçãoT.A. NogueiraM.L. SoaresM.B.P. DiasR.B. Gurgel RochaC.A. Duvoisin JuniorS. AlbuquerqueP.M. LimaE.S. GonçalvesJ.F.C. BataglionG.A. CostaE.V. da SilvaF.M.A. KoolenH.H.F. BezerraD.P. Essential Oil from Bark of Aniba parviflora (Meisn.) Mez (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model.Chem. Biodivers.2021183e200093810.1002/cbdv.202000938 33508178
     [Google Scholar]
  63. SousaF.C.F. MeloC.T.V. MonteiroA.P. LimaV.T.M. GutierrezS.J.C. PereiraB.A. Barbosa-FilhoJ.M. VasconcelosS.M.M. FontelesM.F. VianaG.S.B. Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice.Pharmacol. Biochem. Behav.2004781273310.1016/j.pbb.2004.01.019 15159131
     [Google Scholar]
  64. da TrindadeR.C.S. XavierJ.K.A.M. SetzerW.N. MaiaJ.G.S. da SilvaJ.K.R. Chemical Diversity and Therapeutic Effects of Essential Oils of Aniba Species from the Amazon: A Review.Plants2021109185410.3390/plants10091854 34579388
     [Google Scholar]
  65. Gürağaç DereliF.T. IlhanM. Küpeli AkkolE. Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch. & Mey.J. Ethnopharmacol.2018226111610.1016/j.jep.2018.07.019 30031141
     [Google Scholar]
  66. ButterweckV. NishibeS. SasakiT. UchidaM. Antidepressant effects of apocynum venetum leaves in a forced swimming test.Biol. Pharm. Bull.200124784885110.1248/bpb.24.848 11456130
     [Google Scholar]
  67. DarA. KhatoonS. Antidepressant effects of ethanol extract of Areca catechu in rodents.Phytother. Res.199711217417610.1002/(SICI)1099‑1573(199703)11:2<174::AID‑PTR65>3.0.CO;2‑B
     [Google Scholar]
  68. MahmoudiM. EbrahimzadehM.A. AnsaroudiF. NabaviS.F. NabaviS.M. Antidepressant and antioxidant activities of Artemisia absinthium L. at flowering stage.Afr. J. Biotechnol.200982471707175
     [Google Scholar]
  69. SinghG.K. GarabaduD. MuruganandamA.V. JoshiV.K. KrishnamurthyS. Antidepressant activity of Asparagus racemosus in rodent models.Pharmacol. Biochem. Behav.200991328329010.1016/j.pbb.2008.07.010 18692086
     [Google Scholar]
  70. SairamK. DorababuM. GoelR.K. BhattacharyaS.K. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats.Phytomedicine20029320721110.1078/0944‑7113‑00116 12046860
     [Google Scholar]
  71. NagamaniK. KaurD. AbhinayaniG. GoudG.N. Antidepressant and skeletal muscle relaxant activity of methanolic extracts of Basella alba L.Asian J. Biomed. Pharm. Sci.20166710
     [Google Scholar]
  72. DhingraD. JoshiP. Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems.J. Pharmacol. Pharmacother.201231606210.4103/0976‑500X.92521 22368421
     [Google Scholar]
  73. RehmanS. NaimF. A Comparative Study of Antidepressant Activity of Aqueous Extract of Berberis aristata with Fluoxetine in Rats.International Archives of BioMedical and Clinical Research20162310.21276/iabcr.2016.2.3.28
     [Google Scholar]
  74. InvallyM. KaurG. ButtarH.S. Evaluation of the Antidepressant Activity of Beta vulgaris Alone and in Combination with Fluoxetine in Mice.J. Pharma. Toxic.2016121334110.3923/jpt.2017.33.41
     [Google Scholar]
  75. PedersenM.E. SzewczykB. StachowiczK. WieronskaJ. AndersenJ. StaffordG.I. van StadenJ. PilcA. JägerA.K. Effects of South African traditional medicine in animal models for depression.J. Ethnopharmacol.2008119354254810.1016/j.jep.2008.08.030 18809486
     [Google Scholar]
  76. TabassumT. BariM.A. KuddusM.R. RashidM.A. Analgesic, Anti-diarrheal, Anti-depressant, Membrane Stabilizing and Cytotoxic Activities of Bridelia verrucosa Haines.Bangla. Pharma. J.2019221505510.3329/bpj.v22i1.40073
     [Google Scholar]
  77. KwonS. LeeB. KimM. LeeH. ParkH.J. HahmD.H. Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.Prog. Neuropsychopharmacol. Biol. Psychiatry201034226527010.1016/j.pnpbp.2009.11.015 19932727
     [Google Scholar]
  78. Herrera-RuizM. ZamilpaA. González-CortazarM. Reyes-ChilpaR. LeónE. GarcíaM.P. TortorielloJ. Huerta-ReyesM. Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia.Phytomedicine201118141255126110.1016/j.phymed.2011.06.018 21788126
     [Google Scholar]
  79. ZhuW.L. ShiH.S. WeiY.M. WangS.J. SunC.Y. DingZ.B. LuL. Green tea polyphenols produce antidepressant-like effects in adult mice.Pharmacol. Res.2012651748010.1016/j.phrs.2011.09.007 21964320
     [Google Scholar]
  80. Villas BoasG.R. Stefanello da SilveiraA.P. Feitosa FarinelliB.C. Lima CardosoC.A. ArceE. OesterreichS.A. The ethanolic extract obtained from Campomanesia pubescens (D.C.) O.BERG fruits exerts anxiolytic and antidepressant effects on chronic mild stress model and on anxiety models in Wistar rats: Behavioral evidences.Nutr. Neurosci.2020231162610.1080/1028415X.2018.1466513 29712539
     [Google Scholar]
  81. BaraunaS. KasterM. HeckertB. DonascimentoK. RossiF. TeixeiraE. CavadaB. RodriguesA. LealR. Antidepressant‐like effect of lectin from Canavalia brasiliensis (ConBr) administered centrally in mice.Pharmacol. Biochem. Behav.200685116016910.1016/j.pbb.2006.07.030 16950503
     [Google Scholar]
  82. MoraS. Diaz-VelizG. LungenstrassH. García-GonzálezM. Coto-MoralesT. PolettiC. De LimaT.C.M. Herrera-RuizM. TortorielloJ. Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice.J. Ethnopharmacol.200597219119710.1016/j.jep.2004.10.028 15707751
     [Google Scholar]
  83. ShafeenS. ReddyT.S. ArafathS. NagarjunaS. PadmanabhaR. Evaluation of antianxiety and antidepressant activity of Cassia occidentalis leaves.Asian J. Pharm. Clin. Res.201254750
     [Google Scholar]
  84. AbdelwahabS.I. AlfaifiH. MohanS. Elhassan TahaM. SyameS. ShaalaL. AlsanosyR. Catha edulis Forsk. (Khat): Evaluation of its antidepressant-like Activity.Pharmacogn. Mag.20171350Suppl. 235410.4103/pm.pm_442_16 28808405
     [Google Scholar]
  85. RochaF.F. Lima-LandmanM.T.R. SouccarC. TanaeM.M. De LimaT.C.M. LapaA.J. Antidepressant-like effect of Cecropia glazioui Sneth and its constituents – In vivo and in vitro characterization of the underlying mechanism.Phytomedicine200714639640210.1016/j.phymed.2007.03.011 17498940
     [Google Scholar]
  86. Thamarai SelviP. Senthil KumarM. RajeshR. KathiravanT. Antidepressant activity of ethanolic extract of leaves of Centella asiatica. Linn by in vivo methods.Asian J. Res. Pharm. Sci.2012227679
     [Google Scholar]
  87. WuX. TangB. LiaoX. SuZ. LeeS.M.Y. CaiY. LiC. Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice.Food Funct.20191021212122410.1039/C8FO02474J 30741293
     [Google Scholar]
  88. WinterhoffH. SpenglerB. ChristoffelV. ButterweckV. LöhningA. Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity.Maturitas200344Suppl. 1S51S5810.1016/S0378‑5122(02)00348‑1 12609559
     [Google Scholar]
  89. AlmeidaR.N. NavarroD.S. de AssisT.S. de MedeirosI.A. ThomasG. Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice.J. Ethnopharmacol.199863324725210.1016/S0378‑8741(98)00086‑5 10030729
     [Google Scholar]
  90. AktarK. FoyzunT. Phytochemistry and Pharmacological Studies of Citrus macroptera: A Medicinal Plant Review.Evid. Based Complement. Alternat. Med.201720171978980210.1155/2017/9789802 28740540
     [Google Scholar]
  91. GuptaV. BansalP. KumarP. ShriR. Anxiolytic and antidepressant activities of different extracts from Citrus paradisi var.Foster. J. Pharm. Res.2009218641866
     [Google Scholar]
  92. JainN.N. OhalC.C. ShroffS.K. BhutadaR.H. SomaniR.S. KastureV.S. KastureS.B. Clitoria ternatea and the CNS.Pharmacol. Biochem. Behav.200375352953610.1016/S0091‑3057(03)00130‑8 12895670
     [Google Scholar]
  93. RandhawaK. KumarD. JamwalA. KumarS. Screening of antidepressant activity and estimation of quercetin from Coccinia indica using TLC densitometry.Pharm. Biol.201553121867187410.3109/13880209.2015.1025289 25845639
     [Google Scholar]
  94. LalremruatiC. MalsawmtluangiC. LalhlenmawiaH. Phytochemical screening and evaluation of antidepressant activity of methanolic extract of the spadix of Colocasia affinis Schott.Sci. Vis.201818410411010.33493/scivis.18.04.01
     [Google Scholar]
  95. DhingraD. ValechaR. Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.Med. Sci. Monit.2007137BR155BR161 17599020
     [Google Scholar]
  96. HosseinzadehH. KarimiG. NiapoorM. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice.Acta Hortic.200465043544510.17660/ActaHortic.2004.650.54
     [Google Scholar]
  97. YuZ.F. KongL.D. ChenY. Antidepressant activity of aqueous extracts of Curcuma longa in mice.J. Ethnopharmacol.2002831-216116510.1016/S0378‑8741(02)00211‑8 12413724
     [Google Scholar]
  98. FaryadianS. SydmohammadiA. KhosraviA. KashiriM. FaryadaynP. AbasiN. Aqueous extract of Echium amoenum elevate CSF serotonin and dopamine level in depression rat.Biomed. Pharmacol. J.20147113714210.13005/bpj/463
     [Google Scholar]
  99. SudhakarP. GopalakrishnaN.H. AshokS.K. SudhanshuS.S. ShishirM. VinayakM. NairV. Antidepressant activity of aqueous extract of fruits of Emblica officinalis in mice.Int. J. Appl. Biol. Pharm.201021448454
     [Google Scholar]
  100. CollaA.R.S. MachadoD.G. BettioL.E.B. CollaG. MaginaM.D.A. BrighenteI.M.C. RodriguesA.L.S. Involvement of monoaminergic systems in the antidepressant-like effect of Eugenia brasiliensis Lam. (Myrtaceae) in the tail suspension test in mice.J. Ethnopharmacol.2012143272073110.1016/j.jep.2012.07.038 22884868
     [Google Scholar]
  101. MahmoudiM. EbrahimzadehM.A. AbdiM. ArimiY. FathiH. Antidepressant activities of Feijoa sellowiana fruit.Eur. Rev. Med. Pharmacol. Sci.2015191325102513 26214790
     [Google Scholar]
  102. Herrera-RuizM. Jiménez-FerrerJ.E. De LimaT.C.M. Avilés-MontesD. Pérez-GarcíaD. González-CortazarM. TortorielloJ. Anxiolytic and antidepressant-like activity of a standardized extract from Galphimia glauca.Phytomedicine2006131-2232810.1016/j.phymed.2005.03.003 16360929
     [Google Scholar]
  103. RenL. ZhangH. TaoW. ChenY. ZouZ. GuoX. ShenQ. FengQ. HuJ. The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway.Front. Pharmacol.20221389662810.3389/fphar.2022.896628 35754496
     [Google Scholar]
  104. ZhouB.H. LiX.J. LiuM. WuZ. Ming HuX. Antidepressant-like activity of the Gastrodia elata ethanol extract in mice.Fitoterapia2006777-859259410.1016/j.fitote.2006.06.016 17052862
     [Google Scholar]
  105. TomićM. TovilovićG. ButorovićB. KrstićD. JankovićT. AljancićI. MenkovićN. Neuropharmacological evaluation of diethylether extract and xanthones of.Pharmacol. Biochem. Behav.200581353554210.1016/j.pbb.2005.03.019 15932769
     [Google Scholar]
  106. SakakibaraH. IshidaK. GrundmannO. NakajimaJ. SeoS. ButterweckV. MinamiY. SaitoS. KawaiY. NakayaY. TeraoJ. Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.Biol. Pharm. Bull.20062981767177010.1248/bpb.29.1767 16880641
     [Google Scholar]
  107. DhingraD. SharmaA. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests.Prog. Neuropsychopharmacol. Biol. Psychiatry200630344945410.1016/j.pnpbp.2005.11.019 16443316
     [Google Scholar]
  108. WangW. HuX. ZhaoZ. LiuP. HuY. ZhouJ. ZhouD. WangZ. GuoD. GuoH. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.Prog. Neuropsychopharmacol. Biol. Psychiatry20083251179118410.1016/j.pnpbp.2007.12.021 18289754
     [Google Scholar]
  109. DhamijaH.K. ParasharB. SinghJ. Antidepression potential of herbal drugs: an overview.J. Chem. Pharm. Res.201135725735
     [Google Scholar]
  110. PawarA. GaikwadG. KuchekarB. Antidepressant effect of Hedyotis corymbosa extract in olfactory bulbectomy rats.Pharmacognosy Res.201810221321710.4103/pr.pr_118_17
     [Google Scholar]
  111. ShewaleP. PatilR. HirayY. Antidepressant-like activity of anthocyanidins from Hibiscus rosa-sinensis flowers in tail suspension test and forced swim test.Indian J. Pharmacol.201244445445710.4103/0253‑7613.99303 23087504
     [Google Scholar]
  112. Sánchez-MateoC.C. BonkankaC.X. PradoB. RabanalR.M. Antidepressant properties of some Hypericum canariense L. and Hypericum glandulosum Ait. extracts in the forced swimming test in mice.J. Ethnopharmacol.200597354154710.1016/j.jep.2004.12.019 15740893
     [Google Scholar]
  113. Sánchez-MateoC.C. BonkankaC.X. PradoB. RabanalR.M. Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice.J. Ethnopharmacol.2007112111512110.1016/j.jep.2007.02.019 17383128
     [Google Scholar]
  114. VianaA. do RegoJ.C. von PoserG. FerrazA. HecklerA.P. CostentinJ. Kuze RatesS.M. The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake.Neuropharmacology20054971042105210.1016/j.neuropharm.2005.06.002 16040063
     [Google Scholar]
  115. NathanP.J. Hypericum perforatum (St John’s Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology.J. Psychopharmacol.2001151475410.1177/026988110101500109 11277608
     [Google Scholar]
  116. SakamotoT. MitaniY. NakajimaK. Psychotropic effects of Japanese valerian root extract.Chem. Pharm. Bull. (Tokyo)199240375876110.1248/cpb.40.758 1611689
     [Google Scholar]
  117. El-ShiekhR.A. HusseinD. AttaA.H. MounierS.M. MousaM.R. Abdel-SattarE. Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models.Biomed. Pharmacother.202114011177010.1016/j.biopha.2021.111770 34119929
     [Google Scholar]
  118. WattanathoJ. PangpookieP. SripanidkuK. MuchimapurS. SripanidkuB. Evaluation of the Anxiolytic and Antidepressant effect of alcoholic extract of Kaempferia parviflora in aged rats.Am. J. Agric. Biol. Sci.200722949810.3844/ajabssp.2007.94.98
     [Google Scholar]
  119. GoulartY.C.F. MartinsJ.V.C. SantosA.R. MoreiraL.Y. CalixtoJ.B. CortezD.A.G. AudiE.A. Involvement of serotonin in the antidepressant-like effect of extract from Kielmeyera coriacea stems.Pharm. Biol.200745316917510.1080/13880200701212981
     [Google Scholar]
  120. IsmailH. MirzaB. Evaluation of analgesic, anti-inflammatory, anti-depressant and anti-coagulant properties of Lactuca sativa (CV. Grand Rapids) plant tissues and cell suspension in rats.BMC Complement. Altern. Med.201515119910.1186/s12906‑015‑0742‑0 26115918
     [Google Scholar]
  121. GaldinoP.M. NascimentoM.V.M. SampaioB.L. FerreiraR.N. PaulaJ.R. CostaE.A. Antidepressant-like effect of Lafoensia pacari A. St.-Hil. ethanolic extract and fractions in mice.J. Ethnopharmacol.2009124358158510.1016/j.jep.2009.05.001 19439172
     [Google Scholar]
  122. PrajapatiR. UmbarkarR. ParmarS. ShethN. Antidepressant like activity of Lagenaria siceraria (Molina) Standley fruits by evaluation of the forced swim behavior in rats.Int. J. Nutr. Pharmacol. Neurol. Dis.20111215215610.4103/2231‑0738.84206
     [Google Scholar]
  123. RahmatiB. KiasalariZ. RoghaniM. KhaliliM. AnsariF. Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats.Pharm. Biol.201755195896510.1080/13880209.2017.1285320 28166686
     [Google Scholar]
  124. RubioJ. CaldasM. DávilaS. GascoM. GonzalesG.F. Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice.BMC Complement. Altern. Med.2006612310.1186/1472‑6882‑6‑23 16796734
     [Google Scholar]
  125. SubarnasA. OshimaY. SidikY. OhizumiY. An antidepressant principle of Lobelia inflata L. (Campanulaceae).J. Pharm. Sci.199281762062110.1002/jps.2600810705 1403691
     [Google Scholar]
  126. ParleM. MalikS. Eat tomato a day to keep depression at bay.Asian J. Biol. Sci.201042258262
     [Google Scholar]
  127. ZhuY. LiX. YangW. JiaH. LiuC. PrasharY. BaisS. Anti-depressant Activity of Standardized Macrotyloma uniflorum Extract in Experimental Models of Depression in Rats.Int. J. Pharmacol.201814684885510.3923/ijp.2018.848.855
     [Google Scholar]
  128. YiL.T. XuQ. LiY.C. YangL. KongL.D. Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.Prog. Neuropsychopharmacol. Biol. Psychiatry200933461662410.1016/j.pnpbp.2009.03.001 19285110
     [Google Scholar]
  129. LoboA. ShabarayaS.S.A. An investigation on anti-depressant activity of fresh fruit juice of Malus domestica in experimental animal models.Int. J. Pharm. Pharm. Sci.201842739
     [Google Scholar]
  130. BhattamisraS.K. KhannaV.K. AgrawalA.K. SinghP.N. SinghS.K. Antidepressant activity of standardised extract of Marsilea minuta Linn.J. Ethnopharmacol.20081171515710.1016/j.jep.2008.01.012 18299179
     [Google Scholar]
  131. IshaqH. Anxiolytic and antidepressant activity of different methanolic extracts of Melia azedarach Linn.Pak. J. Pharm. Sci.201629516491655 27731825
     [Google Scholar]
  132. EmamghoreishiM. TalebianpourM.S. Antidepressant effect of Melissa officinalis in the forced swimming test.Daru20091714247
     [Google Scholar]
  133. MolinaM. ContrerasC.M. Tellez-AlcantaraP. Mimosa pudica may possess antidepressant actions in the rat.Phytomedicine19996531932310.1016/S0944‑7113(99)80052‑X 11962537
     [Google Scholar]
  134. Farah IdayuN. Taufik HidayatM. MoklasM.A.M. SharidaF. Nurul RaudzahA.R. ShamimaA.R. ApryaniE. Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.Phytomedicine201118540240710.1016/j.phymed.2010.08.011 20869223
     [Google Scholar]
  135. ArunachalamG. NatesanS. PerumalG.P. VillayuthamR. ManickamK. RamasamyN. Anxiolytic, antidepressant and anti-inflammatory activities of methanol extract of Momordica charantia Linn leaves (Cucurbitaceae).Iran J. Pharmacol. Ther.200874347
     [Google Scholar]
  136. ZhangZ.Q. YuanI. ZhaoN. XuY.K. YangM. LuoZ.P. Antidepressant effect of the ethanolic extracts of the roots of Morinda officinalis in rats and mice.Chung Kuo Yao Hsueh Tsa Chih200035739741
     [Google Scholar]
  137. KaurG. InvallyM. SanzagiriR. ButtarH. Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine.J. Ayurveda Integr. Med.20156427327910.4103/0975‑9476.172384 26834427
     [Google Scholar]
  138. SattayasaiJ. TiamkaoS. PuapairojP. Biphasic effects of Morus alba leaves green tea extract on mice in chronic forced swimming model.Phytother. Res.200822448749210.1002/ptr.2346 18386251
     [Google Scholar]
  139. PatiD. KumarD. MaheshR. KurdekarV. JadhavH.R. A Traditional Indian herb in rodent models of depression.Pharmacol.20101537551
     [Google Scholar]
  140. MoinuddinG. DeviK. Kumar KhajuriaD. Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.Avicenna J. Phytomed.2012227278 25050233
     [Google Scholar]
  141. DhingraD. GoyalP.K. Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.Indian J. Exp. Biol.2008464212218 18512329
     [Google Scholar]
  142. KangM.G. KimY.H. ImA.R. NamB.S. ChaeS.W. LeeM.Y. Antidepressant-like effects of Nelumbo nucifera leaves extract in chronic mild stress model.Korea J. Herb.201429271310.6116/kjh.2014.29.2.7
     [Google Scholar]
  143. MurtalaA.A. AkindeleA.J. Anxiolytic- and antidepressant-like activities of hydroethanol leaf extract of Newbouldia laevis (P.Beauv.) Seem. (Bignoniaceae) in mice.J. Ethnopharmacol.202024911242010.1016/j.jep.2019.112420 31759112
     [Google Scholar]
  144. FajemiroyeJ.O. AdamK. Jordan KZ. AlvesC.E. AderojuA.A. Evaluation of Anxiolytic and Antidepressant-like Activity of Aqueous Leaf Extract of Nymphaea Lotus Linn. in Mice.Iran. J. Pharm. Res.2018172613626 29881419
     [Google Scholar]
  145. AliS.S. Abd El WahabM.G. AyuobN.N. SuliamanM. The antidepressant-like effect of Ocimum basilicum in an animal model of depression.Biotech. Histochem.201792639040110.1080/10520295.2017.1323276 28800278
     [Google Scholar]
  146. MaityT.K. MandalS.C. SahaB.P. PalM. Effect of Ocimum sanctum roots extract on swimming performance in mice.Phytother. Res.200014212012110.1002/(SICI)1099‑1573(200003)14:2<120::AID‑PTR557>3.0.CO;2‑0 10685110
     [Google Scholar]
  147. de SousaF.C.F. PereiraB.A. LimaV.T.M. LacerdaC.D.G. MeloC.T.V. Barbosa-FilhoJ.M. VasconcelosS.M.M. VianaG.S.B. Central nervous system activity of yangambin fromOcotea duckei Vattimo (Lauraceae) in mice.Phytother. Res.200519428228610.1002/ptr.1499 16041767
     [Google Scholar]
  148. Abbasi-MalekiS. KadkhodaZ. Taghizad-FaridR. The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test.J. Tradit. Complement. Med.202010432733510.1016/j.jtcme.2019.01.003 32695649
     [Google Scholar]
  149. MaoQ. HuangZ. IpS. CheC. Antidepressant‐like effect of ethanol extract from Paeonia lactiflora in mice.Phytother. Res.200822111496149910.1002/ptr.2519 18570231
     [Google Scholar]
  150. JinY. CuiR. ZhaoL. FanJ. LiB. Mechanisms of Panax ginseng action as an antidepressant.Cell Prolif.2019526e1269610.1111/cpr.12696 31599060
     [Google Scholar]
  151. WangC. XuF.Q. ShangJ.H. XiaoH. FanW.W. DongF.W. HuJ.M. ZhouJ. Cycloartane triterpenoid saponins from water soluble of Passiflora edulis Sims and their antidepressant-like effects.J. Ethnopharmacol.2013148381281710.1016/j.jep.2013.05.010 23702036
     [Google Scholar]
  152. SantoshP. VenugopalR. NilakashA.S. KunjbihariS. MangalaL. Antidepressant activity of methanolic extract of Passiflora foetida leaves in mice.Int. J. Pharm. Pharm. Sci.201131112115
     [Google Scholar]
  153. OtoboneF.J. SanchesA.C.C. NagaeR. MartinsJ.V.C. SelaV.R. MelloJ.C.P. AudiE.A. Effect of lyophilized extracts from guaraná seeds [ Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats.Phytother. Res.200721653153510.1002/ptr.2089 17397119
     [Google Scholar]
  154. Abouhosseini TabariM. Hajizadeh MoghaddamA. MaggiF. BenelliG. Anxiolytic and antidepressant activities of pelargonium roseum essential oil on swiss albino mice: Possible involvement of serotonergic transmission.Phytother. Res.20183261014102210.1002/ptr.6038 29468757
     [Google Scholar]
  155. JiW.W. LiR.P. LiM. WangS.Y. ZhangX. NiuX.X. LiW. YanL. WangY. FuQ. MaS.P. Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice.Chin. J. Nat. Med.2014121075375910.1016/S1875‑5364(14)60115‑1 25443368
     [Google Scholar]
  156. Es-safiI. MechchateH. AmaghnoujeA. ElbouzidiA. BouhrimM. BencheikhN. HanoC. BoustaD. Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice.Plants2021108157310.3390/plants10081573 34451620
     [Google Scholar]
  157. MoghimiA. BolandghamatS. IranshahiM. Effects of ethanolic extract of pine needles (Pinus eldarica Medw.) on reserpine-induced depression-like behavior in male Wistar rats.Pharmacogn. Mag.201172724825310.4103/0973‑1296.84240 21969797
     [Google Scholar]
  158. YaoC.Y. WangJ. DongD. QianF.G. XieJ. PanS.L. Laetispicine, an amide alkaloid from Piper laetispicum, presents antidepressant and antinociceptive effects in mice.Phytomedicine200916982382910.1016/j.phymed.2009.02.008 19447013
     [Google Scholar]
  159. CapraJ.C. CunhaM.P. MachadoD.G. ZomkowskiA.D.E. MendesB.G. SantosA.R.S. PizzolattiM.G. RodriguesA.L.S. Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: Evidence for the involvement of monoaminergic systems.Eur. J. Pharmacol.20106432-323223810.1016/j.ejphar.2010.06.043 20599906
     [Google Scholar]
  160. HuY. LiuP. GuoD.H. RahmanK. WangD.X. XieT.T. Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms.Pharm. Biol.201048779480010.3109/13880200903280034 20645779
     [Google Scholar]
  161. PiatoÂ.L. RizonL.P. MartinsB.S. NunesD.S. ElisabetskyE. Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice.Phytother. Res.200923451952410.1002/ptr.2664 19067380
     [Google Scholar]
  162. JahromyM.H. KhakpourS. KhorgamiZ. The Antidepressant-Like Effects of Punica granatum (Pomegranate) Extract in Mice.Chin. Med. (Irvine Calif.)2014511610.4236/cm.2014.51001
     [Google Scholar]
  163. YanB. WangD. XingD. DingY. WangR. LeiF. DuL. The antidepressant effect of ethanol extract of radix puerariae in mice exposed to cerebral ischemia reperfusion.Pharmacol. Biochem. Behav.200478231932510.1016/j.pbb.2004.04.010 15219773
     [Google Scholar]
  164. ZimathP.L. DalmagroA.P. RibeiroT.C. da SilvaR.M.L. Lopes de AlmeidaG.R. MalheirosA. da SilvaL.M. de SouzaM.M. Antidepressant-like effect of hydroalcoholic extract from barks of Rapanea ferruginea: Role of monoaminergic system and effect of its isolated compounds myrsinoic acid A and B.Behav. Brain Res.202038911260110.1016/j.bbr.2020.112601 32361037
     [Google Scholar]
  165. WangJ.M. PeiL.X. ZhangY.Y. ChengY.X. NiuC.L. CuiY. FengW.S. WangG.F. Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF.Metab. Brain Dis.201833388589210.1007/s11011‑018‑0202‑x 29468477
     [Google Scholar]
  166. AliB. BashirA.K. TaniraM.O.M. The effect of Rhazya stricta Decne, a traditional medicinal plant, on the forced swimming test in rats.Pharmacol. Biochem. Behav.199859254755010.1016/S0091‑3057(97)00470‑X 9477006
     [Google Scholar]
  167. AmsterdamJ.D. PanossianA.G. Rhodiola rosea L. as a putative botanical antidepressant.Phytomedicine201623777078310.1016/j.phymed.2016.02.009 27013349
     [Google Scholar]
  168. FekaduN. ShibeshiW. EngidaworkE. Evaluation of the antidepressant-like activity of the crude extract and solvent fractions of Rosa Abyssinica Lindley (Rosaceae) using rodent models of depression.J. Clinic. Exp. Pharmacol.20166
     [Google Scholar]
  169. MachadoD.G. BettioL.E.B. CunhaM.P. CapraJ.C. DalmarcoJ.B. PizzolattiM.G. RodriguesA.L.S. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system.Prog. Neuropsychopharmacol. Biol. Psychiatry200933464265010.1016/j.pnpbp.2009.03.004 19286446
     [Google Scholar]
  170. CarbajalD. RaveloY. MolinaV. MasR. ArruzazabalaM.L. D-004, a lipid extract from royal palm fruit, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice.Pharmacol. Biochem. Behav.200992346546810.1016/j.pbb.2009.01.008 19463260
     [Google Scholar]
  171. MoraS. MillánR. LungenstrassH. Díaz-VélizG. MoránJ.A. Herrera-RuizM. TortorielloJ. The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats.J. Ethnopharmacol.20061061768110.1016/j.jep.2005.12.004 16413718
     [Google Scholar]
  172. SeolG.H. ShimH.S. KimP.J. MoonH.K. LeeK.H. ShimI. SuhS.H. MinS.S. Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats.J. Ethnopharmacol.2010130118719010.1016/j.jep.2010.04.035 20441789
     [Google Scholar]
  173. GillM. KinraM. RaiA. ChamallamudiM.R. KumarN. Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model.Neuroreport201829213414010.1097/WNR.0000000000000944 29206699
     [Google Scholar]
  174. MachadoD.G. BettioL.E.B. CunhaM.P. SantosA.R.S. PizzolattiM.G. BrighenteI.M.C. RodriguesA.L.S. Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: Evidence for the involvement of the serotonergic and noradrenergic systems.Eur. J. Pharmacol.20085871-316316810.1016/j.ejphar.2008.03.021 18457827
     [Google Scholar]
  175. XuC. LuoL. TanR.X. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model.J. Ethnopharmacol.2004912-334534910.1016/j.jep.2004.01.012 15120459
     [Google Scholar]
  176. AdebiyiR.A. ElsaA.T. AgaieB.M. EtukE.U. Antinociceptive and antidepressant like effects of Securidaca longepedunculata root extract in mice.J. Ethnopharmacol.2006107223423910.1016/j.jep.2006.03.017 16647235
     [Google Scholar]
  177. RahmanM.R. SharifM. AliM. Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum.Clin. Phytosci.201952
     [Google Scholar]
  178. RodriguesA.L.S. da SilvaG.L. MateussiA.S. FernandesE.S. MiguelO.G. YunesR.A. CalixtoJ.B. SantosA.R.S. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus.Life Sci.200270121347135810.1016/S0024‑3205(01)01498‑9 11885577
     [Google Scholar]
  179. PetreanuM. MaiaP. da Rocha PittarelloJ.L. LochL.C. MonacheF.D. PerezA.L. Solano-AriasG. FilhoV.C. de SouzaM.M. NieroR. Antidepressant-like effect and toxicological parameters of extract and withanolides isolated from aerial parts of Solanum capsicoides All. (Solanaceae).Naunyn Schmiedebergs Arch. Pharmacol.2019392897999010.1007/s00210‑019‑01648‑9 30982080
     [Google Scholar]
  180. GalaniV. PatelB. Effect of hydroalcoholic extract of Sphaeranthus indicus against experimentally induced anxiety, depression and convulsions in rodents.Int. J. Ayurveda Res.201012879210.4103/0974‑7788.64412 20814521
     [Google Scholar]
  181. KabirM. HossainM. Antidepressant, anxiolytic and anti-nociceptive activities of ethanol extract of Steudnera colocasiifolia K. Koch leaves in mice model.J. Coast. Life Med.201531189089410.12980/jclm.3.2015j5‑60
     [Google Scholar]
  182. FreitasA.E. BudniJ. LobatoK.R. BinfaréR.W. MachadoD.G. JacintoJ. VeroneziP.O. PizzolattiM.G. RodriguesA.L.S. Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: Evidence for the involvement of the monoaminergic system.Prog. Neuropsychopharmacol. Biol. Psychiatry201034233534310.1016/j.pnpbp.2009.12.010 20026371
     [Google Scholar]
  183. Guadarrama-CruzG. Alarcon-AguilarF.J. Lezama-VelascoR. Vazquez-PalaciosG. Bonilla-JaimeH. Antidepressant-like effects of Tagetes lucida Cav. in the forced swimming test.J. Ethnopharmacol.2008120227728110.1016/j.jep.2008.08.013 18782612
     [Google Scholar]
  184. DhingraD. ValechaR. Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice.Indian J. Exp. Biol.2007457610616 17821856
     [Google Scholar]
  185. YangH. KimH.J. HongE.J. PyunB.J. KoB.S. LeeH.W. Antidepressant Effect of Tetragonia tetragonoides (Pall.) Kuntze extract on serotonin turnover.Evid. Based Complement. Alternat. Med.201920197312842 30854015
     [Google Scholar]
  186. AdebolaA.O. AyodejiA.O. AdetayoL.I. AdeboyeE.C. Anti-depressant activities of Theobroma cacao extract on reserpine-induced depression in female wistar rats, J. Krishna. Inst. Medical.Sci. Univ.2020912735
     [Google Scholar]
  187. Morteza-SemnaniK. MahmoudiM. RiahiG. Effects of Essential Oils and Extracts from Certain Thymus. Species on Swimming Performance in Mice.Pharm. Biol.200745646446710.1080/13880200701389177
     [Google Scholar]
  188. DhingraD. GoyalP.K. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of Tinospora cordifolia in mice.Indian J. Pharm. Sci.200870676176710.4103/0250‑474X.49118 21369437
     [Google Scholar]
  189. WangZ. ZhangD. HuiS. ZhangY. HuS. Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats.J. Tradit. Chin. Med.201333222823210.1016/S0254‑6272(13)60130‑2 23789222
     [Google Scholar]
  190. NarapoguV. AalsyamN. PokalaN. JayasreeT. JohnP. Evaluation of antidepressant and antioxidant activity of Fenugreek (Trigonella foenum-greacum) seed extract in Wistar rats.J. Chem. Pharm. Res.2018106135140
     [Google Scholar]
  191. GapskiA. GomesT.M. BredunM.A. Ferreira-LimaN.E. LudkaF.K. Bordignon-LuizM.T. BurinV.M. Digestion behavior and antidepressant-like effect promoted by acute administration of blueberry extract on mice.Food Res. Int.201912510861810.1016/j.foodres.2019.108618 31554107
     [Google Scholar]
  192. OshimaY. MatsuokaS. OhizumiY. Antidepressant principles of Valeriana fauriei roots.Chem. Pharm. Bull. (Tokyo)199543116917010.1248/cpb.43.169 7895306
     [Google Scholar]
  193. SubhanF. KarimN. GilaniA.H. SewellR.D.E. Terpenoid content of Valeriana wallichii extracts and antidepressant‐like response profiles.Phytother. Res.201024568669110.1002/ptr.2980 19943315
     [Google Scholar]
  194. PrakashB. BaisR.T. SahuR.K. Screening of antioxidant and antidepressant activity of Vanda tessellata leaves extract.INTERNATIONAL JOURNAL OF GREEN PHARMACY2018124S829S83410.22377/ijgp.v12i04.2262
     [Google Scholar]
  195. AlamM.A. Marjan Mahmoudi, Samira Zolfaghari, A. Allami, M. Ebrahimzadeh, Antidepressant activity of Vicia faba hulls.Pharmacol.20163122126
     [Google Scholar]
  196. AkinpeluL.A. AdegbuyiT.A. AgboolaS.S. OlaonipekunJ.K. OlawuniI.J. AdegokeA.M. OyemitanI.A. OlayiwolaG. Antidepressant Activity and Mechanism of Aqueous Extract of Vigna Unguiculata ssp. Dekindtiana (L.) Walp Dried Aerial Part in Mice.International Journal of Neuroscience and Behavioral Science20175171810.13189/ijnbs.2017.050102
     [Google Scholar]
  197. ShahP.C. TrivediN.A. BhattJ.D. HemavathiK.G. Effect of Withania somnifera on forced swimming test induced immobility in mice and its interaction with various drugs.Indian J. Physiol. Pharmacol.2006504409415 17402272
     [Google Scholar]
  198. OkokonJ. NelsonE. Antidepressant activity of ethanol extract of Zea mays husk.J. Herb. Med.201634
     [Google Scholar]
  199. SharmaV.K. ChauhanN.S. LodhiS. SinghaiA.K. Anti-depressant activity of Zizyphus xylopyrus.Int. J. Phytomed.200911121710.5138/ijpm.2009.0975.0185.05788
     [Google Scholar]
  200. Keugong WadoE. KubickiM. NgatankoA.H.H. Léa BlondelleK.D. Jorelle lindaD. RolandR.N. BalbineK. LamshoeftM. AssongalemA.E. FoyetH.S. Anxiolytic and antidepressant effects of Ziziphus mucronata hydromethanolic extract in male rats exposed to unpredictable chronic mild stress: Possible mechanisms of actions.J. Ethnopharmacol.202026011298710.1016/j.jep.2020.112987 32446929
     [Google Scholar]
  201. KasperS. GastparM. MüllerW.E. VolzH.P. MöllerH.J. SchläfkeS. DienelA. Efficacy of St. John’s wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials.Eur. Arch. Psychiatry Clin. Neurosci.20102601596310.1007/s00406‑009‑0018‑0 19455275
     [Google Scholar]
  202. PanossianA. WikmanG. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity.Pharmaceuticals2010131224
     [Google Scholar]
  203. SmithJ.V. BurdickA.J. GolikP. KhanI. WallaceD. LuoY. Anti-aging effects of Ginkgo biloba extract on gray and white matter regions of the brain.Aging Dis.2019104787796
     [Google Scholar]
  204. RussoA. BorrelliF. Bacopa monniera, a reputed nootropic plant: an overview.Phytomedicine200512430531710.1016/j.phymed.2003.12.008 15898709
     [Google Scholar]
  205. SmithC. The effects of Sceletium tortuosum in an in vivo model of psychological stress.J. Ethnopharmacol.20111331313610.1016/j.jep.2010.08.058 20816940
     [Google Scholar]
  206. GillmanP.K. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity.Br. J. Anaesth.2007996879880 16051647
     [Google Scholar]
  207. CamposA.C. MoreiraF.A. GomesF.V. Del BelE.A. GuimarãesF.S. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.Philos. Trans. R. Soc. Lond. B Biol. Sci.201236716073364337810.1098/rstb.2011.0389 23108553
     [Google Scholar]
  208. CernyA. SchmidK. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double-blind, placebo-controlled, multicentre study).Fitoterapia.1999703221228
     [Google Scholar]
  209. FarooquiA.A. FarooquiT. Nigella sativa Seeds: Folklore Treatment in Moderating Anxiety, Depression, and Stress within Streptozotocin-Induced Rat Model of Alzheimer’s Disease.Front. Nutr.2018575
     [Google Scholar]
  210. RoaiahM.F. ElkhayatY.I. SalehS.Y. Tribulus terrestris Extract Exerts Biphasic Effect on Testicular Function and Reverses Histological Changes in Diet-Induced Obesity.J. Sex. Med.2016131117571768
     [Google Scholar]
  211. KennedyD.O. LittleW. ScholeyA.B. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).Psychosom. Med.2002643463469 15272110
     [Google Scholar]
  212. ManciniE. BeglingerC. DreweJ. ZanchiD. LangU.E. BorgwardtS. Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine201734263710.1016/j.phymed.2017.07.008 28899506
     [Google Scholar]
  213. DietzC. DekkerM. Piqueras-FiszmanB. An intervention study on the effect of matcha tea, in drink and snack bar formats, on mood and cognitive performance.Food Res. Int.201799Pt 1728310.1016/j.foodres.2017.05.002 28784536
     [Google Scholar]
  214. HozawaA. KuriyamaS. NakayaN. Ohmori-MatsudaK. KakizakiM. SoneT. NagaiM. SugawaraY. NittaA. TomataY. NiuK. TsujiI. Green tea consumption is associated with lower psychological distress in a general population: the Ohsaki Cohort 2006 Study.Am. J. Clin. Nutr.20099051390139610.3945/ajcn.2009.28214 19793850
     [Google Scholar]
  215. WhitingP.F. WolffR.F. DeshpandeS. Di NisioM. DuffyS. HernandezA.V. KeurentjesJ.C. LangS. MissoK. RyderS. SchmidlkoferS. WestwoodM. KleijnenJ. Cannabinoids for medical use: A systematic review and meta-analysis.JAMA2015313242456247310.1001/jama.2015.6358 26103030
     [Google Scholar]
  216. NewtonK.M. ReedS.D. LaCroixA.Z. GrothausL.C. EhrlichK. GuiltinanJ. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial.Ann. Intern. Med.20061451286987910.7326/0003‑4819‑145‑12‑200612190‑00003 17179056
     [Google Scholar]
  217. GellerS.E. ShulmanL.P. van BreemenR.B. BanuvarS. ZhouY. EpsteinG. HedayatS. NikolicD. KrauseE.C. PiersenC.E. BoltonJ.L. PauliG.F. FarnsworthN.R. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms.Menopause20091661156116610.1097/gme.0b013e3181ace49b 19609225
     [Google Scholar]
  218. HausenblasH.A. SahaD. DubyakP.J. AntonS.D. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials.J. Integr. Med.201311637738310.3736/jintegrmed2013056 24299602
     [Google Scholar]
  219. LoprestiA.L. DrummondP.D. SmithS.J. A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males.Am. J. Men Health201913210.1177/1557988319835985 30854916
     [Google Scholar]
  220. Agha-HosseiniM. KashaniL. AleyaseenA. GhoreishiA. RahmanpourH. ZarrinaraA.R. AkhondzadehS. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double‐blind, randomised and placebo‐controlled trial.BJOG2008115451551910.1111/j.1471‑0528.2007.01652.x 18271889
     [Google Scholar]
  221. GhajarA. NeishabouriS.M. VelayatiN. GhajarA. NeishabouriA. MokhberN. The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis.Planta Med.20158106488495
     [Google Scholar]
  222. ShahmansouriN. FarokhniaM. AbbasiS.H. KassaianS.E. Noorbala TaftiA.A. GougolA. YekehtazH. ForghaniS. MahmoodianM. SaroukhaniS. Arjmandi-BeglarA. AkhondzadehS. A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients.J. Affect. Disord.201415521622210.1016/j.jad.2013.11.003 24289892
     [Google Scholar]
  223. TalaeiA. Hassanpour MoghadamM. Sajadi TabassiS.A. MohajeriS.A. FarzaeiM.H. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot clinical trial.J. Affect. Disord.20151744515610.1016/j.jad.2014.11.035 25484177
     [Google Scholar]
  224. MazidiM. ShemshianM. MousaviS.H. NorouzyA. KermaniT. MoghimanT. SadeghiA. MokhberN. Ghayour-MobarhanM. FernsG.A.A. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression.J. Complement. Integr. Med.201613219519910.1515/jcim‑2015‑0043 27101556
     [Google Scholar]
  225. LoprestiA.L. MaesM. MakerG.L. HoodS.D. DrummondP.D. Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study.J. Affect. Disord.201416736837510.1016/j.jad.2014.06.001 25046624
     [Google Scholar]
  226. SanmukhaniJ. SatodiyaV. TrivediJ. PatelT. TiwariD. PanchalB. GoelA. TripathiC.B. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial.Phytother. Res.201428457958510.1002/ptr.5025 23832433
     [Google Scholar]
  227. EsmailyH. Hosseini-TabatabaeiA. RahimdelA. RakhshandehH. Niazi MoghadamM.R. RustaieeA. An investigation of the efficacy of curcumin in the treatment of moderate to severe major depressive disorder: a randomized double-blind controlled trial.BMC Complement. Altern. Med.2015151375
     [Google Scholar]
  228. RollandA. FleurentinJ. LanhersM.C. YounosC. MisslinR. MortierF. PeltJ. Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties.Planta Med.199157321221610.1055/s‑2006‑960076 1680240
     [Google Scholar]
  229. EylesD.W. LiuP.Y. JoshP. CappaiR. WeickertC.S. Intramuscular testosterone is associated with suicidality in men.Eur. J. Endocrinol.20121672251261
     [Google Scholar]
  230. BirksJ. Grimley EvansJ. Ginkgo biloba for cognitive impairment and dementia.Cochrane Libr.20091CD00312010.1002/14651858.CD003120.pub3 19160216
     [Google Scholar]
  231. WoelkH. ArnoldtK.H. KieserM. HoerrR. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial.J. Psychiatr. Res.2014588893 16808927
     [Google Scholar]
  232. MazzaM. CapuanoA. BriaP. MazzaS. Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer’s dementia in a randomized placebo‐controlled double‐blind study.Eur. J. Neurol.200613998198510.1111/j.1468‑1331.2006.01409.x 16930364
     [Google Scholar]
  233. WoelkH. ArnoldtK.H. Kava-Kava extract WS 1490 versus placebo in anxiety disorders-a randomized placebo-controlled 25-week outpatient trial.Pharmacopsych.20074006187188
     [Google Scholar]
  234. LindeK. BernerM.M. KristonL. St John’s wort for major depression.Cochrane Database Syst. Rev.200820084CD000448 18843608
     [Google Scholar]
  235. KasperS. VolzH.P. MöllerH.J. DienelA. KieserM. Continuation and long-term maintenance treatment with Hypericum extract WS® 5570 after recovery from an acute episode of moderate depression — A double-blind, randomized, placebo controlled long-term trial.Eur. Neuropsychopharmacol.2008181180381310.1016/j.euroneuro.2008.06.006 18694635
     [Google Scholar]
  236. GastparM. SingerA. ZellerK. Efficacy and tolerability of hypericum extract STW 3-VI in patients with moderate depression: a double-blind, randomized, placebo-controlled clinical trial.Adv. Ther.2005225414422
     [Google Scholar]
  237. WoelkH. SchläfkeS. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder.Phytomedicine2010172949910.1016/j.phymed.2009.10.006 19962288
     [Google Scholar]
  238. OndrizekR.R. ChanP.J. PattonW.C. KingA. Inhibition of human sperm motility by specific herbs used in alternative medicine.J. Assist. Reprod. Genet.1999162879110.1023/A:1022568823262 10079411
     [Google Scholar]
  239. WuttkeW. JarryH. ChristoffelV. SpenglerB. Seidlová-WuttkeD. Chaste tree (Vitex agnus-castus) – Pharmacology and clinical indications.Phytomedicine200310434835710.1078/094471103322004866 12809367
     [Google Scholar]
  240. TaylorJ.A. WeberW. StandishL. QuinnH. A randomized double-blind, placebo-controlled trial of valerian for the acute treatment of sleep disorder due to aviation noise.Sleep20032618893
     [Google Scholar]
  241. VorbachE.U. GortelmeyerR. BruningJ. GliemrothJ.P. Therapie von Insomnien: Klinische Wirksamkeit und Vertraglichkeit eines Valerianawurzel-Extraktes.Psychopharmakotherapie.2003104959
     [Google Scholar]
  242. SarrisJ. KavanaghD.J. ByrneG. AdenaM. BoneK.M. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum.Psychopharmacology (Berl.)20132253631642 19430766
     [Google Scholar]
  243. KasperS. GastparM. MüllerW.E. VolzH.P. MöllerH.J. SchläfkeS. DienelA. Lavender oil preparation Silexan is effective in generalized anxiety disorder – a randomized, double-blind comparison to placebo and paroxetine.Int. J. Neuropsychopharmacol.201417685986910.1017/S1461145714000017 24456909
     [Google Scholar]
  244. LiaoJ.F. HungW.Y. ChenC.F. LinY.E. Rhodiola—An update review of its phytochemistry and pharmacology.Phytother. Res.2018321120072024
     [Google Scholar]
  245. KhianmanN. PattanittumP. ThinkhamropJ. LumbiganonP. AnnerbergA. Relaxation therapy for preventing and treating preterm labor.Cochrane Database Syst. Rev.20138
     [Google Scholar]
  246. TafazoliM. ShadnoushM. OstadrahimiA. A randomized double-blind, placebo-controlled study of probiotic Lactobacillus reuteri ADR-1 on Endotoxemia in patients with preterm labor.Br. J. Nutr.20181206671678
     [Google Scholar]
  247. HolmesE.A. The Lancet Psychiatry Commission on psychological treatments research in tomorrow’s science.Lancet Psychiatry201965367396 31006425
     [Google Scholar]
  248. LeeC.S. KimY.J. JangY.J. The efficacy of pregnancy intervention on preventing postpartum depression in high-risk women.J. Investig. Med.2014622641642
     [Google Scholar]
  249. AmsterdamJ.D. LiY. SoellerI. RockwellK. MaoJ.J. ShultsJ. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder.J. Clin. Psychopharmacol.200929437838210.1097/JCP.0b013e3181ac935c 19593179
     [Google Scholar]
  250. MaoJ.J. Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo-controlled trial.J. Clin. Trials20166217 25610752
     [Google Scholar]
  251. CasesJ. IbarraA. FeuillèreN. RollerM. SukkarS.G. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.Med. J. Nutrition Metab.20114321121810.1007/s12349‑010‑0045‑4 22207903
     [Google Scholar]
  252. BallardC.G. O’BrienJ.T. ReicheltK. PerryE.K. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.J. Clin. Psychiatry200263755355810.4088/JCP.v63n0703 12143909
     [Google Scholar]
  253. KennedyD.O. LittleW. HaskellC.F. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress.Phytother. Res.2002167621625 12410541
     [Google Scholar]
  254. FarooquiZ. AhmedF. RizviA. Neurochemical evidence for the antidepressant effects of anethole, a monoterpene component of sweet fennel.Clin. Phytosci.2018417
     [Google Scholar]
  255. GhannadiA. HajhashemiV. JafarabadiH. AnvariA.H. Sedative and hypnotic effects of Iranian traditional medicine plants used for insomnia: A systematic review.Nat. Sci. Sleep2012417
     [Google Scholar]
  256. ReayJ.L. KennedyD.O. ScholeyA.B. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity.J. Psychopharmacol.200519435736510.1177/0269881105053286 15982990
     [Google Scholar]
  257. KimH.G. ChoJ.H. YooS.R. LeeJ.S. HanJ.M. LeeN.H. AhnY.C. SonC.G. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial.PLoS One201384e6127110.1371/journal.pone.0061271 23613825
     [Google Scholar]
  258. KimS. KimM.S. ParkM.K. KimH.J. Effects of Panax ginseng extract on exercise-induced oxidative stress.J. Sports Med. Phys. Fitness2009492201208 19528900
     [Google Scholar]
  259. KimH.J. KimP. ShinC.Y. KimH.S. An aqueous extract of Panax ginseng increases whole-body insulin sensitivity in mice with diet-induced obesity.Ann. Nutr. Metab.2013634296303
     [Google Scholar]
  260. BartonD.L. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA.Support. Care Cancer201321720792086 19415341
     [Google Scholar]
  261. BartonD.L. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2.J. Natl. Cancer Inst.201010210746756 23853057
     [Google Scholar]
  262. AkhondzadehS. KashaniL. MobaseriM. HosseiniS.H. NikzadS. KhaniM. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial.J. Clin. Pharm. Ther.200126536937310.1046/j.1365‑2710.2001.00366.x 11679027
     [Google Scholar]
  263. MiyasakaL.S. AtallahÁ.N. SoaresB.G. Passiflora for anxiety disorder.Cochrane Database Syst. Rev.20171 17253512
     [Google Scholar]
  264. SmithC.A. The effect of topical chamomile on immunoglobulin E antibody production in mice.Phytother. Res.2011256829834
     [Google Scholar]
  265. KasperS. GastparM. MüllerW.E. VolzH.P. MöllerH.J. DienelA. SchläfkeS. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial.Int. Clin. Psychopharmacol.201025527728710.1097/YIC.0b013e32833b3242 20512042
     [Google Scholar]
  266. AndreatiniR. SartoriV.A. SeabraM.L.V. LeiteJ.R. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo‐controlled pilot study.Phytother. Res.200216765065410.1002/ptr.1027 12410546
     [Google Scholar]
  267. Mokhtari-ZaerA. KhazdairM.R. BoskabadyM.H. HabibiP. The effect of hydro-alcoholic extract of valerian root on histopathologic changes of cerebellum following repetitive running training exercises in rats.Physiol. Pharmacol.2014182159168
     [Google Scholar]
  268. MohammadiA. The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers.Nutr. Neurosci.2017227474484 29215971
     [Google Scholar]
  269. AhmadiS.M. Passionflower in the treatment of attention-deficit hyperactivity disorder in children and adolescents.Therapy201183123129
     [Google Scholar]
  270. ChandrasekharK. KapoorJ. AnishettyS. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.Indian J. Psychol. Med.201234325526210.4103/0253‑7176.106022 23439798
     [Google Scholar]
  271. PratteM.A. NanavatiK.B. YoungV. MorleyC.P. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera).J. Altern. Complement. Med.2014201290190810.1089/acm.2014.0177 25405876
     [Google Scholar]
  272. AndradeC. AswathA. ChaturvediS.K. SrinivasaM. RaguramR. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy oaf an ethanolic extract of withania somnifera.Indian J. Psychiatry2000423295301 21407960
     [Google Scholar]
  273. BhattacharyaS.K. BhattacharyaA. SairamK. GhosalS. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.Phytomedicine20007646346910.1016/S0944‑7113(00)80030‑6 11194174
     [Google Scholar]
  274. BentS. PadulaA. MooreD. PattersonM. MehlingW. Valerian for sleep: a systematic review and meta-analysis.Am. J. Med.2006119121005101210.1016/j.amjmed.2006.02.026 17145239
     [Google Scholar]
  275. MischoulonD. RosenbaumJ.F. Herbal Medicines in the Treatment of Psychiatric Disorders: A Systematic Review.Am. J. Psychiatry20171746422432
     [Google Scholar]
  276. BystritskyA. Use of complementary and alternative medicine in a large sample of anxiety patients.Psychosomatics2008496493500 22304968
     [Google Scholar]
  277. MillsS. BoneK. The Essential Guide to Herbal Safety.St. Louis, MOElsevier Health Sciences2005
     [Google Scholar]
  278. SarrisJ. Kava for generalised anxiety disorder: a 16-week double-blind, randomised, placebo-controlled study.Aust. N. Z. J. Psychiatry2012461110841092 31813230
     [Google Scholar]
/content/journals/cnt/10.2174/0126659786306271240905054531
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The Potential Role of Herbal Plants in the Management of Depression: Pre-Clinical and Clinical Evidence
Current Nutraceuticals 6, E26659786306271 (2025); https://doi.org/10.2174/0126659786306271240905054531
/content/journals/cnt/10.2174/0126659786306271240905054531
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  • Article Type:     Review Article
Keyword(s): anti-depressant; clinical studies; Depression; herbal extract; mechanism of action; therapy

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