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2000
Volume 21, Issue 10
  • ISSN: 1573-4013
  • E-ISSN: 2212-3881

Abstract

Introduction

Creatine is a semi-essential nutrient involved in cellular bioenergetics. While its effects on energy metabolism are well established, its potential influence on appetite regulation remains unclear. This study examined the association between dietary creatine intake and serum leptin levels in a nationally representative U.S. population.

Methods

Data were analyzed from NHANES III (1988–1994), including 6,415 participants who completed a 24-hour dietary recall and had fasting serum leptin levels measured. Creatine intake (g/day) was estimated based on established food composition values. Serum leptin was quantified radioimmunoassay. Multivariate regression models adjusted for age, gender, and body mass index (BMI) were used to assess associations.

Results

The mean creatine intake was 0.91 ± 0.87 g/day, and the mean serum leptin concentration was 12.6 ± 11.8 µg/L. A significant inverse association was observed between dietary creatine intake and serum leptin levels (B = -1.586, < 0.01), independent of age, gender, and BMI.

Discussion

Higher dietary creatine intake is associated with lower circulating leptin concentrations, suggesting a potential role for creatine in the regulation of long-term energy balance through mechanisms that extend beyond its established effects on muscle metabolism.

Conclusion

Higher dietary creatine intake is associated with lower serum leptin levels, suggesting a potential role for creatine in appetite regulation. Further research is needed to clarify underlying mechanisms and causality.

© 2025 Bentham Science Publishers
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2025-07-21
2026-02-02

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References

  1. OstojicS.M. ForbesS.C. Creatine, a conditionally essential nutrient: Building the case.Adv. Nutr.2022131343710.1093/advances/nmab11134662902
     [Google Scholar]
  2. WyssM. Kaddurah-DaoukR. Creatine and creatinine metabolism.Physiol. Rev.20008031107121310.1152/physrev.2000.80.3.110710893433
     [Google Scholar]
  3. RackayovaV. CudalbuC. PouwelsP.J.W. BraissantO. Creatine in the central nervous system: From magnetic resonance spectroscopy to creatine deficiencies.Anal. Biochem.201752914415710.1016/j.ab.2016.11.00727840053
     [Google Scholar]
  4. BonillaD.A. KreiderR.B. StoutJ.R. ForeroD.A. KerksickC.M. RobertsM.D. RawsonE.S. Metabolic basis of creatine in health and disease: A bioinformatics-assisted review.Nutrients2021134123810.3390/nu1304123833918657
     [Google Scholar]
  5. NiklassonF. AgrenH. Brain energy metabolism and blood-brain barrier permeability in depressive patients: Analyses of creatine, creatinine, urate, and albumin in CSF and blood.Biol. Psychiatry1984198118312066498242
     [Google Scholar]
  6. RanisavljevM. TodorovicN. PanicJ. AndjelicB. VranesM. OstojicS.M. Short-term fasting affects biomarkers of creatine metabolism in healthy men and women.Hum. Nutr. Metab.202334420021710.1016/j.hnm.2023.200217
     [Google Scholar]
  7. JatoiA. SteenP.D. AthertonP.J. MooreD.F. RowlandK.M. Le-LindqwisterN.A. AdonizioC.S. JaslowskiA.J. SloanJ. LoprinziC. A double-blind, placebo-controlled randomized trial of creatine for the cancer anorexia/weight loss syndrome (N02C4): An Alliance trial.Ann. Oncol.20172881957196310.1093/annonc/mdx23228475678
     [Google Scholar]
  8. StefanakisK. UpadhyayJ. Ramirez-CisnerosA. PatelN. SahaiA. MantzorosC.S. Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health.Metabolism202416115605610.1016/j.metabol.2024.15605639481533
     [Google Scholar]
  9. BakianA.V. HuberR.S. SchollL. RenshawP.F. KondoD. Dietary creatine intake and depression risk among U.S. adults.Transl. Psychiatry20201015210.1038/s41398‑020‑0741‑x32066709
     [Google Scholar]
  10. TodorovicN. KorovljevD. StajerV. JorgaJ. OstojicS.M. Creatine consumption and liver disease manifestations in individuals aged 12 years and over.Food Sci. Nutr.20231121134114110.1002/fsn3.315136789045
     [Google Scholar]
  11. NedeljkovicD. BalticS. TodorovicN. OstojicS.M. Creatine intake is not associated with elevated circulating cystatin C levels in individuals with and without kidney dysfunction in the general population.J. Am. Nutr. Assoc.202544433834110.1080/27697061.2024.243248439778146
     [Google Scholar]
  12. JuhnM.S. TarnopolskyM. Potential side effects of oral creatine supplementation: A critical review.Clin. J. Sport Med.19988429830410.1097/00042752‑199810000‑000079884794
     [Google Scholar]
  13. TerjungR.L. ClarksonP. EichnerE.R. GreenhaffP.L. HespelP.J. IsraelR.G. KraemerW.J. MeyerR.A. SprietL.L. TarnopolskyM.A. WagenmakersA.J. WilliamsM.H. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation.Med. Sci. Sports Exerc.200032370671710.1097/00005768‑200003000‑0002410731017
     [Google Scholar]
  14. BenziG. CeciA. Creatine as nutritional supplementation and medicinal product.J. Sports Med. Phys. Fitness200141111011317142
     [Google Scholar]
  15. KutzM.R. GunterM.J. Creatine monohydrate supplementation on body weight and percent body fat.J. Strength Cond. Res.200317481782110.1519/1533‑4287(2003)017<0817:CMSOBW>2.0.CO;214636103
     [Google Scholar]
  16. KoenigC.A. BenardotD. CodyM. ThompsonW.R. Comparison of creatine monohydrate and carbohydrate supplementation on repeated jump height performance.J. Strength Cond. Res.20082241081108610.1519/JSC.0b013e31816a58c618545204
     [Google Scholar]
  17. BenderA. SamtlebenW. ElstnerM. KlopstockT. Long-term creatine supplementation is safe in aged patients with Parkinson disease.Nutr. Res.200828317217810.1016/j.nutres.2008.01.00119083405
     [Google Scholar]
  18. SemerediS. StajerV. OstojicJ. VranesM. OstojicS.M. Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial.Nutrition20195716216610.1016/j.nut.2018.04.00930170305
     [Google Scholar]
  19. de GuingandD.L. PalmerK.R. SnowR.J. Davies-TuckM.L. ElleryS.J. Risk of adverse outcomes in females taking oral creatine monohydrate: A systematic review and meta-analysis.Nutrients2020126178010.3390/nu1206178032549301
     [Google Scholar]
  20. LiuZ. XiaoT. LiuH. Leptin signaling and its central role in energy homeostasis.Front. Neurosci.202317123852810.3389/fnins.2023.123852838027481
     [Google Scholar]
  21. JéquierE. Leptin signaling, adiposity, and energy balance.Ann. N. Y. Acad. Sci.2002967137938810.1111/j.1749‑6632.2002.tb04293.x12079865
     [Google Scholar]
  22. GalbraithR.A. FurukawaM. LiM. Possible role of creatine concentrations in the brain in regulating appetite and weight.Brain Res.200611011859110.1016/j.brainres.2006.05.03216781683
     [Google Scholar]
/content/journals/cnf/10.2174/0115734013395816250715145327
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Dietary Creatine Intake and Serum Leptin Levels: A Population-Based Analysis
Curr. Nutr. Food Sci. 21, 1081 (2025); https://doi.org/10.2174/0115734013395816250715145327
/content/journals/cnf/10.2174/0115734013395816250715145327
/content/journals/cnf/10.2174/0115734013395816250715145327
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  • Article Type:     Research Article
Keyword(s): adenosine triphosphate; appetite regulation; Creatine; dietary creatine; leptin; regression

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