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2000
Volume 32, Issue 32
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Introduction

The incidence of Breast Cancer (BC), a prevalent malignancy in women, has gone up recently, although the molecular pathways underlying the carcinogenesis of BC are still unknown. Long non-coding RNAs (lncRNAs) have become important tumor progression regulators.

Methods

The present study has revealed increased expression of LINC00651 in BC tissues through a thorough investigation of whole-transcriptome resequencing on matched BC and normal tissues from 8 patients. It is yet unknown precisely as to what biological function LINC00651 serves in BC.

To obtain further insight, 39 matched pairs of breast tumors and normal tissues underwent Real-time quantitative Polymerase Chain Reaction (RT-qPCR) for validation. The validated cohort's clinicopathologic characteristics were then carefully examined. Following short interfering RNA transfection, proliferation, colony formation, migration, invasion, and examination of phenotypes associated with the Epithelial-mesenchymal Transition (EMT) were conducted in BC cell lines (MDA-MB-231 and BT-549).

Results

Our findings have confirmed that LINC00651 plays a role in augmenting BC cell lines' proliferation, migration, and invasion. Consequently, LINC00651 can be considered a potential new therapeutic target for BC treatment.

Conclusion

As breast cancer remains a significant health concern, understanding its molecular underpinnings is crucial for developing effective treatments. The identification of LINC00651 as a promoter of BC cell growth and metastasis has suggested that it could be a promising target for future therapeutic interventions, potentially offering new avenues for improved patient outcomes.

© 2025 Bentham Science Publishers
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/content/journals/cmc/10.2174/0109298673328556240813111417
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LINC00651, A Long Non-coding RNA, Acts as a Catalyst in the Progression of Breast Cancer by Promoting Proliferation, Migration, and Invasion
Curr. Med. Chem. 32, 7117 (2025); https://doi.org/10.2174/0109298673328556240813111417
/content/journals/cmc/10.2174/0109298673328556240813111417
/content/journals/cmc/10.2174/0109298673328556240813111417
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  • Article Type:     Research Article
Keyword(s): Breast cancer; chemotherapy; invasion; LINC00651; migration; proliferation

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