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2000
Volume 32, Issue 33
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Reactive Oxygen Species (ROS) and the redoxin system regulate the redox environment. Thus, they mediate various physiological and pathological processes involved in tumor occurrence and development by activating redox-sensitive genes and regulating redox signaling pathways, including tumor cell proliferation, migration, invasion, and various cell death types. Therefore, the mechanism underlying redox environment regulation must be clarified to accurately target this mechanism and improve the effect of tumor treatment. This review introduces redox-sensitive transcription factors and their activated downstream signaling pathways, and the application of inhibitors targeting related transcription factors in tumor therapy.

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The Role of Redox Environment in Tumors
Curr. Med. Chem. 32, 7265 (2025); https://doi.org/10.2174/0109298673309338240819063253
/content/journals/cmc/10.2174/0109298673309338240819063253
/content/journals/cmc/10.2174/0109298673309338240819063253
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  • Article Type:     Review Article
Keyword(s): carcinogens; defense system; glutathione; Redox environment; targeted therapeutic inhibitors; tumor

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