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2000
Volume 32, Issue 31
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

Nickel nanomaterials play an important role in biological applications, but they have high toxicity and poor biocompatibility. To overcome these defects, we coated the surface of Ni nanotubes with different thicknesses of SiO to reduce cytotoxicity, improve biocompatibility, and broaden their biological application value.

Objective

This study aimed to construct Ni nanotubes with different thicknesses of SiO nanoshells; investigate the effects of silicon layer thickness, incubation time, and cell line category on the cytotoxicity of the as-synthesized materials, and evaluate the biocompatibility of the materials by biological enzymes. The Ni@SiO-NH was selected for use as an adsorbent for the adsorption and purification of histidine-rich proteins, such as Bovine Hemoglobin (BHb).

Methods

Magnetic Ni nanotubes were prepared by the template-chemical deposition method. A modified version of the Stöber process was used for the SiO coating of Ni@SiO nanotubes, and adjusted by changing the volume of TEOS for different thicknesses of SiO nanoshells.

Results

Different cell lines containing tumor cells and normal cells were used in the toxicity experiment, which confirmed the low cytotoxicity and good biocompatibility of Ni@SiO. To achieve high efficiency of immobilization and purification of histidine-rich proteins, Ni@SiO-NH was obtained by introducing the amino functional group. The Ni@SiO-NH was found to possess lower cytotoxicity and higher adsorption capacity compared to other synthesized materials. Besides, the Ni@SiO-NH also exhibited good selectivity of histidine-rich proteins.

Conclusion

This work has not only provided ideas for reducing the cytotoxicity and improving the biocompatibility of biological nanomaterials, but also laid a foundation for subsequent biological applications.

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Construction and Biological Evaluation of Different Nanoshell Thickness Ni@SiO2 Nanotubes as Good Protein Separation Carriers for Bovine Hemoglobin
Curr. Med. Chem. 32, 6867 (2025); https://doi.org/10.2174/0109298673307793240802062318
/content/journals/cmc/10.2174/0109298673307793240802062318
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  • Article Type:     Research Article
Keyword(s): biocompatibility; core-shell structure; Cytotoxicity; magnetic nanotubes; protein adsorption; surface modification

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