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image of Advanced Strategies for Enhancing Analytical Techniques of Solid Phase Microextraction: An Overview

Abstract

Solid-phase microextraction (SPME) is a popular technique for sample preparation, known for reducing the need for solvents and integrating well with chromatography instruments. Recent advancements focus on improving extraction efficiency through new coating materials. Despite improvements in analytical instruments, sample preparation remains a challenge, especially for detecting trace substances. This review explores the latest developments in SPME, particularly new coating materials, including nanomaterials like metal oxide nanoparticles, metal nanoparticles, carbon-based nanomaterials, and silica nanoparticles. These materials improve enrichment, analyte selectivity, and resistance to interference. The review also examines how analyte properties and coating composition affect extraction performance, helping researchers design better coatings. Additionally, the manuscript discusses modern applications of SPME, such as direct coupling with mass spectrometry and sampling, highlighting its growing importance in analytical fields. By summarizing recent innovations and applications, this review aims to provide valuable insights into developing more effective SPME techniques using advanced adsorbents for detecting and analyzing a wide range of substances.

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2025-07-18
2025-09-04

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Advanced Strategies for Enhancing Analytical Techniques of Solid Phase Microextraction: An Overview
Bentham Science Publishers ; https://doi.org/10.2174/0122133461384287250711063801
/content/journals/cgc/10.2174/0122133461384287250711063801
/content/journals/cgc/10.2174/0122133461384287250711063801
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  • Article Type:     Review Article
Keywords: sample preparation ; Solid phase microextraction ; mass spectrometry ; miniaturization ; automation ; nanomaterials

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