Ovulation Induction in Anovulatory Patients with Polycystic Ovary Syndrome

Ovarian dysfunction is probably the pivotal feature of polycystic ovary syndrome (PCOS) making this syndrome the major cause of anovulatory infertility in developed countries. Several approaches have been proposed to induce ovulation in PCOS patients. Notwithstanding lifestyle modifications, clomiphene citrate, surgery and, finally, gonadotropins are the classical and still effective therapeutic options, new drugs, such as metformin and aromatase inhibitors, are today available in the treatment of anovulation related to PCOS. The aim of the present review is to describe all therapeutic approaches to the anovulatory PCOS patients.