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2000
Volume 20, Issue 5
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903
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Abstract

Mpox is an emerging zoonotic viral infection caused by the Monkeypox virus that has become a global health threat. Though vaccines for smallpox are available and used, therapeutics are scarce for Mpox, and increasing drug-resistant strains are found. Among recent advances in antiviral therapy, amphiphilic small molecules have been found, which could potentially serve as inhibitors of viral replication. This editorial describes the challenges presented by the Mpox virus as it evolves over time and delves deeper into more recent studies based on computational drug design and nanoassembly. In this regard, small amphiphilic molecules have established their potential to inhibit viral entry and replication through interaction with viral envelope proteins. This editorial also describes the current state of research into such small molecules. It underlines their promise in the potential struggle against Mpox and explores their mechanisms of action, therapeutic efficacy, and prospects for clinical application.

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2025-02-14
2025-12-07

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References

  1. WangJ. NguyenL. VolanteV. DanielJ. PreussC. Mpox: New challenges with the disease.In: Rising Contagious Diseases: Basics Management, and Treatments.John Wiley & Sons, Inc.2024203010.1002/9781394188741.ch3
     [Google Scholar]
  2. ChhabraM. ShanthamurthyC.D. KumarN.V. Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2.J. Med. Chem.20246714118851191610.1021/acs.jmedchem.4c00487 38995734
     [Google Scholar]
  3. IbrahimH. ErankiA. Mpox: An emerging global orthopoxvirus outbreak.In: Global Virology IV: Viral Disease Diagnosis and Treatment Delivery in the 21st Century.Springer2024143153
     [Google Scholar]
  4. JiangL. XuA. GuanL. TangY. ChaiG. FengJ. A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies.In: Exploration.Wiley Online Library202420230112
     [Google Scholar]
  5. GiganteC.M. TakakuwaJ. McGrathD. Notes from the field: Mpox cluster caused by tecovirimat-resistant monkeypox virus — Five states, october 2023–february 2024.MMWR Morb. Mortal. Wkly. Rep.2024734090390510.15585/mmwr.mm7340a3 39388389
     [Google Scholar]
  6. The Antiviral Tecovirimat Is Safe but Did Not Improve Clade I Mpox Resolution in Democratic Republic of the Congo.Annapolis, MD, USANational Institutes of Health Report2024
     [Google Scholar]
  7. ShahB.M. ModiP. Breaking barriers: Current advances and future directions in Mpox therapy.Curr. Drug Targets2024251627610.2174/0113894501281263231218070841 38151842
     [Google Scholar]
  8. PasikhovaY. Antiviral agents: Cidofovir and brincidofovir.In: Global Virology IV: Viral Disease Diagnosis and Treatment Delivery in the 21st Century.Springer2024251277
     [Google Scholar]
  9. SmithT.G. GiganteC.M. WynnN.T. Tecovirimat resistance in mpox patients, United States, 2022–2023.Emerg. Infect. Dis.202329122426243210.3201/eid2912.231146 37856204
     [Google Scholar]
  10. KumarS. GuruparanD. KaruppananK. KumarK.J.S. Comprehensive insights into monkeypox (mpox): Recent advances in epidemiology, diagnostic approaches and therapeutic strategies.Pathogens2024141110.3390/pathogens14010001 39860962
     [Google Scholar]
  11. AlameerR.M. YamaniA. Al-SaudA. The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases.Int. J. Infect. Dis.202414310701510.1016/j.ijid.2024.107015 38521447
     [Google Scholar]
  12. WangJ. Shahed-AI-MahmudM. ChenA. LiK. TanH. JoyceR. An overview of antivirals against monkeypox virus and other orthopoxviruses.J. Med. Chem.20236674468449010.1021/acs.jmedchem.3c00069 36961984
     [Google Scholar]
  13. SagdatK. BatyrkhanA. KanayevaD. Exploring monkeypox virus proteins and rapid detection techniques.Front. Cell. Infect. Microbiol.202414141422410.3389/fcimb.2024.1414224 38863833
     [Google Scholar]
  14. de AraújoL.P. de Melo SantosN.C. CorsettiP.P. de AlmeidaL.A. Immunoinformatic approach for rational identification of immunogenic peptides against host entry and/or exit Mpox proteins and potential multiepitope vaccine construction.J. Infect. Dis.2024229Suppl. 2S285S29210.1093/infdis/jiad443 37804521
     [Google Scholar]
  15. PaulD. SahaS. BasuS. ChakrabortiT. Computational analysis of pathogen-host interactome for fast and low-risk in-silico drug repurposing in emerging viral threats like Mpox.Sci. Rep.20241411873610.1038/s41598‑024‑69617‑8 39134619
     [Google Scholar]
  16. PyrćK. MilewskaA. DuranE.B. SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray.Sci. Rep.20211112001210.1038/s41598‑021‑99404‑8 34625610
     [Google Scholar]
  17. DasP.P. SenguptaS. BalramD. LianK-Y. AzizovS. NeogiU.K. Recent advancements of nanoparticles for antiviral therapy.Adv Nat Sci Nanosci Nanotechnol202415404300110.1088/2043‑6262/1/4/043001
     [Google Scholar]
  18. DashS.R. KunduC.N. Advances in nanomedicine for the treatment of infectious diseases caused by viruses.Biomater. Sci.202311103431344910.1039/D2BM02066A 36974930
     [Google Scholar]
  19. RochaB. de MoraisL.A. VianaM.C. CarneiroG. Promising strategies for improving oral bioavailability of poor water-soluble drugs.Expert Opin. Drug Discov.202318661562710.1080/17460441.2023.2211801 37157841
     [Google Scholar]
/content/journals/cdth/10.2174/0115748855364446250208172119
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  • Article Type:     Editorial
Keyword(s): amphiphilic small molecules; antiviral; drug resistance; Mpox virus; tecovirimat; viral envelope; zoonotic viral

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