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2000
Volume 20, Issue 5
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Background

Selenium is an essential trace element that plays a role in the regulation of the metabolism of thyroid hormones. This study was designed to evaluate the effect of selenium on the volume of thyroid nodules in euthyroid patients.

Methods

In this Randomized clinical trial, a total of 60 euthyroid patients with benign thyroid nodules (solitary or multinodular goiter) and normal serum selenium were randomly divided into the intervention and control (n=30 each) groups. The intervention group received selenium 200 μg/day while the control group received placebo for 3 months. A thyroid ultrasound was used to measure thyroid nodule volume.

Results

Selenium supplementation (200 µg/day) retained the serum selenium levels of participants in the intervention group (=0.251), while the control group showed a significant drop in serum selenium levels (=0.002). Moreover, the thyroid nodule volume in the intervention group showed a significant decrease after selenium supplementation (=0.004); however, a nonsignificant increase was observed in thyroid nodule volume in the control group (=0.262).

Conclusion

Selenium supplementation may reduce benign thyroid nodule volume in euthyroid patients.

Clinical Trial Registration Number

IRCT20170710035001N2.

© 2025 Bentham Science Publishers
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2025-09-23

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Effects of Selenium Supplementation on Thyroid Nodule Volume in Euthyroid Patients: A Randomized Clinical Trial
Curr Drug Ther 20, 779 (2025); https://doi.org/10.2174/0115748855283065240403073316
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  • Article Type:     Research Article
Keyword(s): euthyroid; Selenium; serum selenium levels; supplementation; thyroid; thyroid nodule volume

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