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image of Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights

Abstract

Introduction

Butrin, a flavonoid glycoside derived from , has garnered attention for its neuroprotective effects attributed to its multifaceted pharmacological profile. It modulates dopamine and norepinephrine levels and exhibits antioxidant, anti-inflammatory, and mitochondrial-protective actions. These properties position butrin as a promising candidate for therapeutic intervention in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. This review consolidates mechanistic insights, preclinical evidence, and therapeutic perspectives of butrin to assess its potential clinical applicability in managing neurodegenerative disorders.

Methods

This review critically analyzes existing preclinical studies on the neuroprotective effects of butrin. Emphasis is placed on its mechanisms of action, including mitigation of oxidative stress, suppression of neuroinflammation, enhancement of neurotrophic factors, and preservation of mitochondrial integrity. Additionally, the review explores current limitations in clinical translation and evaluates emerging drug delivery strategies aimed at improving its therapeutic potential.

Results

Preclinical evidence indicates that butrin effectively counters excitotoxicity and protein aggregation, key pathological features of neurodegenerative disorders. It attenuates neuropathological processes and demonstrates synergistic effects when combined with other neuroprotective and anti-inflammatory agents. Nonetheless, its poor bioavailability and limited ability to cross the blood-brain barrier remain significant barriers to clinical application.

Discussion

Despite its promising pharmacological profile, the clinical translation of butrin is constrained by absorption challenges and suboptimal pharmacokinetics. Innovative strategies, such as nanocarrier-based delivery systems, drug repurposing, and combination therapies, may enhance its therapeutic efficacy. Addressing these limitations is crucial for advancing butrin from bench to bedside.

Conclusion

Butrin exhibits compelling neuroprotective properties supported by robust preclinical data. However, large-scale clinical trials are essential to validate its efficacy. Integrating advanced drug delivery systems and personalized medicine approaches may unlock its full potential in managing neurodegenerative diseases.

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2025-09-29
2025-12-05

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/content/journals/cdrr/10.2174/0125899775398736250911114640
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Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights
Bentham Science Publishers ; https://doi.org/10.2174/0125899775398736250911114640
/content/journals/cdrr/10.2174/0125899775398736250911114640
/content/journals/cdrr/10.2174/0125899775398736250911114640
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  • Article Type:     Review Article
Keywords: dopamine modulation ; brain-derived neurotrophic factor ; neuroinflammation ; oxidative stress ; Neuroprotection ; glutamate excitotoxicity

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