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- ISSN: 1570-1638
- E-ISSN: 1875-6220
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Convection Enhanced Delivery of Macromolecules for Brain Tumors
- Source: Current Drug Discovery Technologies, Volume 9, Issue 4, Dec 2012, p. 305 - 310
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- 01 Dec 2012
Abstract
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
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