Current Drug Discovery Technologies - Online First
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Evaluation of Cytotoxicity and Antimicrobial Activity of Thanatin Recombinant Peptide against Some Oral Bacteria: A Novel Approach against Bacterial Pathogens in Dentistry
Available online: 24 February 2025More LessObjectiveThis study investigated the antimicrobial properties of the thanatin peptide against oral bacteria associated with dental caries and endodontic failures. Additionally, the cytotoxic effects of this peptide on human gingival fibroblast cells (HGFCs) were assessed.Methods and MaterialsThe antimicrobial property of thanatin was tested on Streptococcus mutans, Streptococcus salivarius, Streptococcus oralis, and Read More
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Renal Impairment Caused by Statins in Rats Can Be Restored by Thymoquinone
Available online: 23 January 2025More LessBackground Atorvastatin (ATO) is an HMG-CoA reductase inhibitor used to lower blood cholesterol, but it causes renal injury in high doses. Thymoquinone (TQ), is a natural antioxidant that has been shown to protect the kidney through its anti-inflammatory, antioxidant, & antiapoptotic, effects. Objective The current study aimed to investigate whether posttreatment TQ could reverse ATO-induced renal injury, and the pos Read More
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Long Non-Coding RNA HCP5 Affects Ferroptosis in Lung Adenocarcinoma through miR-17-5p/HOXA7 Axis
Authors: Qingyun Pan, Zige Tang, Jiayu Zheng, Lingxin Yan and Quanfang ChenAvailable online: 21 October 2024More LessBackgroundFerroptosis, a regulated cell death initiated by Fe-dependent lipoperoxidation, is closely linked to the development of lung adenocarcinoma (LUAD). LncRNA human leukocyte antigen complex P5 (HCP5) has been confirmed as oncogenic in LUAD, but its function in ferroptosis is unknown.ObjectiveBased on the previous bioinformatics mining of the ceRNA (competitive endogenous RNA) network HCP Read More
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