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- ISSN: 1570-1638
- E-ISSN: 1875-6220
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Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry for Drug Development
- Source: Current Drug Discovery Technologies, Volume 7, Issue 3, Sep 2010, p. 223 - 231
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- 01 Sep 2010
Abstract
Hydrophilic interaction chromatography (HILIC) offers a difference in selectivity as compared to traditional normal phase and reversed-phase liquid chromatography and therefore has great potential for the separation of a variety of pharmaceuticals. This review is devoted to summarizing HILIC coupled to tandem mass spectrometric (MS/MS) methods for the rapid, sensitive and accurate determinations of small molecules employed for supporting drug discovery. The perspectives and challenges on performing HILIC-MS/MS assays are also presented.
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