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2000
Volume 23, Issue 1
  • ISSN: 1570-1638
  • E-ISSN: 1875-6220

Abstract

Diabetes mellitus (DM) is a prevalent metabolic disorder with a rapidly rising global incidence, presenting a significant burden to healthcare systems worldwide. Flavonoids, a class of naturally occurring polyphenolic compounds, are well-documented for their diverse pharmacological activities, particularly their anti-diabetic and anti-inflammatory effects. These secondary metabolites are commonly found in fruits, vegetables, and fungi and are classified into six main subclasses: flavanols, flavones, flavanones, isoflavones, anthocyanidins, and chalcones. The interplay between hyperglycemia, inflammation, and vascular complications in diabetes is now well recognized. Flavonoids with anti-diabetic properties may help mitigate inflammation by reducing hyperglycemia through various mechanisms. This review explores the antidiabetic potential and molecular mechanisms of citrus flavonoids, drawing on updated evidence from and studies. Flavonoids are shown to regulate biomarkers of glycemic control, lipid metabolism, renal function, hepatic enzymes, and antioxidant defenses. They also modulate signaling pathways implicated in glucose uptake and insulin sensitivity, which are central to the development of diabetes and its complications. Furthermore, this review synthesizes current knowledge on the antidiabetic effects of dietary flavonoids, emphasizing their molecular mechanisms in modulating key pathways such as glucose transporters, hepatic enzymes, tyrosine kinase inhibitors, AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs), and nuclear factor kappa B (NF-κβ). Further research is essential to deepen our understanding of flavonoids' therapeutic mechanisms in managing diabetes.

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/content/journals/cddt/10.2174/0115701638333208250522050837
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Therapeutic Potential of Flavonoids in Diabetes Mellitus Management: Molecular Insights and the Future Directions for Drug Design
Current Drug Discovery Technologies 23, e15701638333208 (2026); https://doi.org/10.2174/0115701638333208250522050837
/content/journals/cddt/10.2174/0115701638333208250522050837
/content/journals/cddt/10.2174/0115701638333208250522050837
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  • Article Type:     Review Article
Keyword(s): biomarkers; Diabetes mellitus; flavonoids; hyperglycaemia; inflammation; metabolic disorder

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