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2000
Volume 22, Issue 5
  • ISSN: 1570-1638
  • E-ISSN: 1875-6220

Abstract

Still today, peptic ulcer disease (PUD) is a major digestive illness that affects millions of people around the world every year. This study looks at both traditional and herbal ways of treating PUD, focusing on how they work, how well they work, and whether they can work together. Pharmaceuticals like antibiotics, proton pump inhibitors (PPIs), and H2-receptor antagonists are common ways to treat the condition. In more serious cases, surgery may also be an option. The use of medical plants in phytotherapy, an herbal treatment, has shown promise in helping people with PUD deal with their symptoms and speed up the healing of ulcers. (Pomelo), a plant in the Rutaceae family, may be able to help treat PUD because it has functional and antioxidant properties. In addition, studies on how well different plants treat PUD have shown that they have anti-inflammatory and cytoprotective qualities. Also, the parts of photosynthesis that plants use contain many beneficial substances that might help with the treatment of PUD. This all-around method would deal with many pathogenic pathways at the same time. More study needs to be done to learn more about how herbal therapies can be used to treat PUD and how they can be combined with other common treatments.

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2025-01-21
2025-09-10
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References

  1. FashnerJ. GituA.C. Diagnosis and treatment of peptic ulcer disease and H. pylori infection.Am. Fam. Physician2015914236242 25955624
    [Google Scholar]
  2. TriantafyllidiA. XanthosT. PapaloisA. TriantafillidisJ.K. Herbal and plant therapy in patients with inflammatory bowel disease.Ann. Gastroenterol.2015282210220 25830661
    [Google Scholar]
  3. LauretM. PérezI. RodrigoL. Peptic ulcer disease.Austin J. Gastroenterol.20152510551063
    [Google Scholar]
  4. ShellE.J. Pathophysiology of peptic ulcer disease.Physician Assist. Clin.20216460361110.1016/j.cpha.2021.05.005
    [Google Scholar]
  5. OngL.L. LinC.H. Adhesion, infection, and therapeutic treatment of Helicobacter pylori: A review on current aspects and future promise.Discover Applied Sciences20246632310.1007/s42452‑024‑05923‑0
    [Google Scholar]
  6. Al-FakhranyO.M. ElekhnawyE. Helicobacter pylori in the post-antibiotics era: From virulence factors to new drug targets and therapeutic agents.Arch. Microbiol.2023205930110.1007/s00203‑023‑03639‑0 37550555
    [Google Scholar]
  7. TarasconiA. CoccoliniF. BifflW.L. Perforated and bleeding peptic ulcer: WSES guidelines.World J. Emerg. Surg.2020151310.1186/s13017‑019‑0283‑9 31921329
    [Google Scholar]
  8. SweeneyC. Analyses of NSAID Induced GI bleed related hospitalization discharges from 2016 to 2018 in the United States.Doctoral dissertation, Rutgers The State University of New Jersey, Rutgers School of Health Professions2016
    [Google Scholar]
  9. AzhariH UnderwoodF KingJ The global incidence of peptic ulcer disease and its complications at the turn of the 21st century: A systematic review. Official J Am Coll Gastroenterol | ACG2018113S6845
    [Google Scholar]
  10. GhasemianA. FattahiA. Shokouhi MostafaviS.K. Herbal medicine as an auspicious therapeutic approach for the eradication of Helicobacter pylori infection: A concise review.J. Cell. Physiol.201923410168471686010.1002/jcp.28363 30847906
    [Google Scholar]
  11. MazumderA. YadavB. SharmaH. Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.Plant Sci. Today2021841006101410.14719/pst.1350
    [Google Scholar]
  12. LeeS.P. SungI.K. KimJ.H. LeeS.Y. ParkH.S. ShimC.S. Risk factors for the presence of symptoms in peptic ulcer disease.Clin. Endosc.201750657858410.5946/ce.2016.129 28008163
    [Google Scholar]
  13. AlapakaM.R. AravaS. PopuriY. A glimpse on herbal anti-ulcer agents.Res J Pharm and Phytochem20191129710610.5958/0975‑4385.2019.00018.9
    [Google Scholar]
  14. DunlapJ.J. PattersonS. Peptic ulcer disease.Gastroenterol. Nurs.201942545145410.1097/SGA.0000000000000478 31574075
    [Google Scholar]
  15. TadesseT.Y. ZelekeM.M. DagnewS.B. Review of ethnobotanical and ethnopharmacological evidence of some Ethiopian medicinal plants traditionally used for peptic ulcer disease treatment.Clin. Exp. Gastroenterol.20221517118710.2147/CEG.S384395 36186925
    [Google Scholar]
  16. XieX. RenK. ZhouZ. DangC. ZhangH. The global, regional and national burden of peptic ulcer disease from 1990 to 2019: A population-based study.BMC Gastroenterol.20222215810.1186/s12876‑022‑02130‑2 35144540
    [Google Scholar]
  17. DadfarA. EdnaT.H. Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years.World J. Gastroenterol.202026355302531310.3748/wjg.v26.i35.5302 32994689
    [Google Scholar]
  18. AhmadB A RaoM U MuhammadA Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer. J Appl Pharm Sci20144808090
  19. MolaoaS.Z. Prevalence of Helicobacter pylori infection and the incidence of the associated malignant and peptic ulcer disease (PUD) at nelson mandela academic hospital: A retrospective analysis.J. Drug Assess.2021101576110.1080/21556660.2020.1854560 34104536
    [Google Scholar]
  20. MustefaA. NardosA. HailuD. DeynoS. Phytochemistry, efficacy, and safety of medicinal plants used traditionally for the management of peptic ulcer diseases in Ethiopia: A systematic review.Clin Phytosci202391910.1186/s40816‑023‑00362‑7
    [Google Scholar]
  21. ZatorskiH. Pathophysiology and risk factors in peptic ulcer disease.Int Gastro Dis2017272010.1007/978‑3‑319‑59885‑7_2
    [Google Scholar]
  22. HanM. CleryA. LiuJ. Banxia Xiexin Decoction for patients with peptic ulcer or chronic gastritis infected with Helicobacter pylori.J. Tradit. Chin. Med. Sci.20196212213010.1016/j.jtcms.2019.04.001
    [Google Scholar]
  23. ShojaeianA. KhalilianA. MehrpoyaM. PoorolajalJ. DastanD. Efficacy of a standardised herbal formulation in Helicobacter pylori positive patients with gastritis or peptic ulcer: A triple-blind randomised clinical trial.J. Herb. Med.20234110070610.1016/j.hermed.2023.100706
    [Google Scholar]
  24. SaheedS. OladipoA.E. SunmonuT.O. BalogunF.O. AshafaA.O. The purview of phytotherapy in the management of gastric ulcer.Stomach Disord201823
    [Google Scholar]
  25. AhmedS.R. RabbeeM.F. RoyA. Therapeutic promises of medicinal plants in Bangladesh and their bioactive compounds against ulcers and inflammatory diseases.Plants2021107134810.3390/plants10071348 34371551
    [Google Scholar]
  26. AgbatutuA. Ogie-OdiaE.A. IfedeleM.O. AbdulrasaqF.M. EseigbeD. ImadeF.N. Ethnobotanical survey of plants used in the management of peptic ulcer diseases in wukari metropolis.Biol Med Nat Prod Chem2022112137143
    [Google Scholar]
  27. BeredaG. Peptic Ulcer disease: Definition, pathophysiology, and treatment.J Biomed Biol Sci202212110
    [Google Scholar]
  28. NisaZ U ShareefU NadeemW Role of medicinal plants in the treatment of peptic ulcer. MedERA-J CMH LMC IOD202131
    [Google Scholar]
  29. HuangS.C. SheuB.S. LeeS.C. YangH.B. YangY.J. Etiology and treatment of childhood peptic ulcer disease in Taiwan: A single center 9-year experience.J. Formos. Med. Assoc.20101091758110.1016/S0929‑6646(10)60024‑1 20123589
    [Google Scholar]
  30. YegenB.C. Lifestyle and peptic ulcer disease.Curr. Pharm. Des.201824182034204010.2174/1381612824666180510092303 29745325
    [Google Scholar]
  31. TahirM. RahmanM.A. KhushtarM. Gastroprotective effect of Hyssopus officinalis L. leaves via reduction of oxidative stress in indomethacin-induced gastric ulcer in experimental rats.Drug Chem. Toxicol.202245129130010.1080/01480545.2019.1685537 31694395
    [Google Scholar]
  32. YangJ. YangH. DaiY. Evidence construction of Chinese herbal formulae for the treatment of H. pylori positive peptic ulcer: A Bayesian network Meta-analysis.Phytomedicine202210515432710.1016/j.phymed.2022.154327 35905565
    [Google Scholar]
  33. ChenT.H. ChengH.T. YehC.T. Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori.Transl. Res.202123211512010.1016/j.trsl.2020.12.006 33352297
    [Google Scholar]
  34. SinghK. SinghL.R. MishraA. Therapeutic potential of indigenous medicinal plants against gastric ulcer.Ann. Phytomed.202211120621410.54085/ap.2022.11.1.20
    [Google Scholar]
  35. HuangX. SunX. YuX. QianH. Efficacy and safety of Sijunzi Decoction for peptic ulcers: A systematic review and meta-analysis.J. Tradit. Chin. Med. Sci.20185323725410.1016/j.jtcms.2018.11.001
    [Google Scholar]
  36. KunaL. JakabJ. SmolicR. Raguz-LucicN. VcevA. SmolicM. Peptic ulcer disease: A brief review of conventional therapy and herbal treatment options.J. Clin. Med.20198217910.3390/jcm8020179 30717467
    [Google Scholar]
  37. YadavS K Review of conventional and herbal treatment for peptic ulcer disease. NVEO-Natural Volatiles & Essential Oils J | NVEO2021631024
    [Google Scholar]
  38. IsaacJ.U. EzeM. KerenhappuchI.U. Peptic ulcer disease and its implications.Res Gastric Manag Hepatol.20221111510.58489/2836‑6204/004
    [Google Scholar]
  39. KrupavaramB BabuA K PillayS M A review of herbal treatment for functional gastrointestinal disorders and infection.Prog Microbes Mol Biol202361
    [Google Scholar]
  40. IkedaS. TamamuroT. HamashimaC. AsakaM. Evaluation of the cost‐effectiveness of Helicobacter pylori eradication triple therapy vs. conventional therapy for ulcers in Japan.Aliment. Pharmacol. Ther.200115111777178510.1046/j.1365‑2036.2001.01106.x 11683692
    [Google Scholar]
  41. ManuP. RogozeaL.M. SandorV. Dumitra DanL. Pharmacological management of peptic ulcer: a century of expert opinions in cecil textbook of medicine.Am. J. Ther.2021285e552e55910.1097/MJT.0000000000001439
    [Google Scholar]
  42. TripathyS. AfrinR. Herbal treatment alternatives for peptic ulcer disease.J. Drug Deliv. Ther.201663273310.22270/jddt.v6i3.1210
    [Google Scholar]
  43. AddissoukyT.A. AliM.M.A. El Tantawy El SayedI. WangY. Recent advances in diagnosing and treating Helicobacter pylori through botanical extracts and advanced technologies.Arch. Pharmacol. Ther.202351536610.33696/Pharmacol.4.045
    [Google Scholar]
  44. HuangS.C. WuW.J. LeeY.J. Gastroprotective effects of Machilus zuihoensis Hayata bark against acidic ethanol-induced gastric ulcer in mice.J. Tradit. Complement. Med.202313551152010.1016/j.jtcme.2023.05.006 37693097
    [Google Scholar]
  45. DevhareL.D. GokhaleN. In silico anti-ulcerative activity evaluation of some bioactive compound from Cassia tora and Butea monosperma through moleculer docking approach.Int. J. Pharm. Sci. Res.202314210001008
    [Google Scholar]
  46. ArdalaniH. HadipanahA. SahebkarA. Medicinal plants in the treatment of peptic ulcer disease: A review.Mini Rev. Med. Chem.202020866270210.2174/1389557520666191227151939 31880244
    [Google Scholar]
  47. RoyA.J. MautC. GogoiH.K. AhmedS.I. KashyapA. A review on herbal drugs used in the treatment of peptic ulcer.Curr. Drug Discov. Technol.2023203e12122221186910.2174/1570163820666221212142221 36515023
    [Google Scholar]
  48. SapkotaB. JainV. Evaluation of anti-ulcer activity of Citrus Maxima (brum.) leaves extract in experimental animals.J Clin Exp Pharmacol202111216
    [Google Scholar]
  49. MandalariG. BisignanoC. CirmiS. NavarraM. Effectiveness of citrus fruits on Helicobacter pylori.Evid. Based Complement. Alternat. Med.201720171837926210.1155/2017/8379262 28408943
    [Google Scholar]
  50. SinghP.K. EaswariT.S. Emerging trends and their impacts on peptic ulcer diseases: Treatments and techniques.Curr. Drug Ther.202217121110.2174/1574885517666220307115813
    [Google Scholar]
  51. KeshariP. SrivastavaA.K. JaiswalS. MukerjeeA. Exploring the therapeutic potential of Psidium guajava and b vulgaris extracts for peptic ulcers: A natural alternative to conventional medications.J. Pharmacogn. Phytochem.2023124425210.22271/phyto.2023.v12.i4a.14692
    [Google Scholar]
  52. DekaH. TamuliA.K. Peels as an important natural source for different house hold and medicinal uses-A Short Review.J Intellects20211198111
    [Google Scholar]
  53. YadavR. KumarJ. SinghA.K. YadavA. GuptaP.C. A review on the pathogenesis, treatment and prevention of peptic ulcer disease.Asian J Med Prin Clin Pract202254183197
    [Google Scholar]
  54. CardosI.A. ZahaD.C. SindhuR.K. CavaluS. Revisiting therapeutic strategies for H. pylori treatment in the context of antibiotic resistance: Focus on alternative and complementary therapies.Molecules20212619607810.3390/molecules26196078 34641620
    [Google Scholar]
  55. SharmaV. RaniG. SinghD. Beneficial remedies of ayurvedic medicines against allopathic drugs in peptic ulcer.J Adv Zool202344
    [Google Scholar]
  56. SongH. HouX. ZengM. Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway.J. Ethnopharmacol.202025911297910.1016/j.jep.2020.112979 32442585
    [Google Scholar]
  57. PawarR.S. PatilU.K. GadekarR. SingourP.K. ChaurasiyaP.K. A potential of some medicinal plants as an antiulcer agents.Pharmacogn. Rev.20104813614610.4103/0973‑7847.70906 22228953
    [Google Scholar]
  58. PrajapatiS. AlamS. AhmadS. A review on herbal drugs used to treat ulcer.Int J Pharm Chem Sci201213970972
    [Google Scholar]
  59. BhatnagarM. SisodiaS.S. BhatnagarR. Antiulcer and antioxidant activity of Asparagus Racemosus Willd and Withania somnifera Dunal in rats.Ann. N. Y. Acad. Sci.20051056126127810.1196/annals.1352.027 16387694
    [Google Scholar]
  60. VoglerB.K. ErnstE. Aloe Vera: A systematic review of its clinical effectiveness.Br. J. Gen. Pract.199949447823828 10885091
    [Google Scholar]
  61. HammanJ.H. Composition and applications of Aloe Vera leaf gel.Molecules20081381599161610.3390/molecules13081599 18794775
    [Google Scholar]
  62. EamlamnamK. PatumrajS. VisedopasN. Thong-NgamD. Effects of Aloe Vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats.World J. Gastroenterol.200612132034203910.3748/wjg.v12.i13.2034 16610053
    [Google Scholar]
  63. GohilK. PatelJ. GajjarA. Pharmacological review on Centella asiatica: A potential herbal cure-all.Indian J. Pharm. Sci.201072554655610.4103/0250‑474X.78519 21694984
    [Google Scholar]
  64. AbdullaM.A. Al-bayatyF.H. YounisL.T. HassanM.I.A. Anti-ulcer activity of centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats.J. Med. Plants Res.201041312531259
    [Google Scholar]
  65. ChattopadhyayI. NandiB. ChatterjeeR. BiswasK. BandyopadhyayU. BanerjeeR.K. Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: Effect on H+-K+-ATPase, oxidative damage and apoptosis.Inflammopharmacology200412215317610.1163/1568560041352257 15265317
    [Google Scholar]
  66. KimD.C. KimS.H. ChoiB.H. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors.Biol. Pharm. Bull.200528122220222410.1248/bpb.28.2220 16327153
    [Google Scholar]
  67. PrucksunandC. IndrasukhsriB. LeethochawalitM. HungspreugsK. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer.Southeast Asian J. Trop. Med. Public Health2001321208215 11485087
    [Google Scholar]
  68. HakkimF.L. ShankarC.G. GirijaS. Chemical composition and antioxidant property of holy basil (Ocimum sanctum L.) leaves, stems, and inflorescence and their in vitro callus cultures.J. Agric. Food Chem.200755229109911710.1021/jf071509h 17924700
    [Google Scholar]
  69. DharmaniP. KuchibhotlaV.K. MauryaR. SrivastavaS. SharmaS. PalitG. Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.J. Ethnopharmacol.2004932-319720610.1016/j.jep.2004.02.029 15234753
    [Google Scholar]
  70. PrakashP. GuptaN. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review.Indian J. Physiol. Pharmacol.2005492125131 16170979
    [Google Scholar]
  71. KhanK.H. Roles of Emblica Officinalis in medicine- A review.Bot. Res. Int.200924218228
    [Google Scholar]
  72. Al-RehailyA.J. Al-HowirinyT.S. Al-SohaibaniM.O. RafatullahS. Gastroprotective effects of ‘Amla’ Emblica Officinalis on in vivo test models in rats.Phytomedicine20029651552210.1078/09447110260573146 12403160
    [Google Scholar]
  73. VermaM. Investigation on antiulcer activity of aegle marmelos root as experimental, biochemical and histological study.J. Pharm. Res.201031025232528
    [Google Scholar]
  74. SwapnaP. RobertsonS. ElumalaiA. EswaraiahM.C. NirmalaK. Evaluation of antiulcer activity of calotropis gigantea r. br leaves.IJPSR20112112938294110.13040/IJPSR.0975‑8232.2(11).2938‑41
    [Google Scholar]
  75. BorrelliF. IzzoA.A. The plant kingdom as a source of anti-ulcer remedies.Phytother. Res.200014858159110.1002/1099‑1573(200012)14:8<581:AID‑PTR776>3.0.CO;2‑S 11113992
    [Google Scholar]
  76. AlyA.M. Al-AlousiL. SalemH.A. Licorice: A possible anti-inflammatory and anti-ulcer drug.AAPS PharmSciTech200561E74E8210.1208/pt060113 16353966
    [Google Scholar]
  77. SalehA. MohammedA. TawfeqA. MohammedA. IbrahimA. SyedR. Gastric antiulcer activity of a pungent spice ferula asafoetida in L. in rats.Farmacia2011596750759
    [Google Scholar]
  78. SaravananR. DhachinamoorthiD. SenthilkumarK. SrilakshmiM. Antibacterial activity of Euphorbia hirta extracts.IJRAP201233439441
    [Google Scholar]
  79. KhareC.P. Indian medicinal plants.Springer200710.1007/978‑0‑387‑70638‑2
    [Google Scholar]
  80. LawandeY.S. HaseR.S. JadhavD.P. HyalijT.A. Recent advances in research of antiulcer drugs of natural origin: A review.IJPRD2012311160170
    [Google Scholar]
  81. AggarwalB.B. PrasadS. ReuterS. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “Reverse pharmacology” and “bedside to bench” approach.Curr. Drug Targets201112111595165310.2174/138945011798109464 21561421
    [Google Scholar]
  82. JainD.L. BahetiA.M. JainS.R. KhandelwalK.R. Use of medicinal plants among tribes in Satpuda region of Dhule and Jalgaon districts of Maharashtra – An ethnobotanical survey.Indian J. Tradit. Knowl.201091152157
    [Google Scholar]
  83. KumarR. BhagatN. Ethnomedicinal plants of district Kathua (J&K).Int. J. Med. Aromat. Plants201224603611
    [Google Scholar]
  84. JoyP.P. ThomasJ. MathewS. SkariaB.P. A textbook of medicinal plants.Kerala Agricultural University1998
    [Google Scholar]
  85. SaurabhA. MishraA.S. GuptaS. A review on medicinal plants effective in the treatment of ulcers or with antiulcer activities.Int J Biopharm Toxicol Res201221266276
    [Google Scholar]
  86. ElayaA.R. VijaylakshmiM. GarikapatiG. Acorus calamus Linn.: Chemistry and biology.Res J Pharm Tech200922256261
    [Google Scholar]
  87. SahaiS. PavithranP. BarpujariI. Biopiracy: Imitation not innovation.Gene Campaign2007
    [Google Scholar]
  88. NadkarniA.K. Indian material medica.Popular Prakashan Pvt Ltd20091
    [Google Scholar]
  89. VermaM. Investigation on antiulcer activity of Aegle marmelos root: Experimental, biochemical, and histological study.J. Pharm. Res.201031025232528
    [Google Scholar]
  90. RamasubramaniarajaR. NiranjanM.B. Peptic ulcer and phytochemistry: An overview.J. Pharm. Res.201141156160
    [Google Scholar]
  91. MauryaU. SrivastavaS. Traditional Indian herbal medicine as antipyretic, antiulcer, antidiabetic, and anticancer: A review.IJRPC20111411521159
    [Google Scholar]
  92. NikhatS. KhanJ.A. AhmadG. Experimentally proven herbs in peptic ulcer disease.IJPSR20123823872392
    [Google Scholar]
  93. KosifR. AktaG. ÖztekinA. Microscopic examination of placenta of rats prenatally exposed to Aloe barbadensis: A preliminary study.Int. J. Morphol.200826227528110.4067/S0717‑95022008000200005
    [Google Scholar]
  94. GuptaM. ShawB.P. Uses of medicinal plants in Panchakarma Ayurvedic therapy.Indian J. Tradit. Knowl.200983372378
    [Google Scholar]
  95. GirijaK. LakshmanK. Anti-hyperlipidemic activity of methanol extracts of three plants of Amaranthus in triton-WR 1339 induced hyperlipidemic rats.Asian Pac. J. Trop. Biomed.201111S62S6510.1016/S2221‑1691(11)60125‑1
    [Google Scholar]
  96. KumarP.K. JainS.K. LalN. AlokS. A review on antiulcer activity.IJPSR20123824872493
    [Google Scholar]
  97. KambleS.Y. PatilS.R. SawantP.S. SawantS. PawarS.G. SinghE.A. Study on plants used in traditional medicine by Bhilla tribe of Maharashtra.Indian J. Tradit. Knowl.201093591598
    [Google Scholar]
  98. PriyaC.L. RaoK.V.B. Ethnobotanical and ethnopharmacological aspects of Argemone mexicana Linn.: An overview.IJPSR20123721432148
    [Google Scholar]
  99. CraciunescuO. ConstantinD. GasparA. TomaL. UtoiuE. MoldovanL. Evaluation of antioxidant activity of Arnica montana L. and Artemisia absinthium L. ethanolic extracts.Chem. Cent. J.201261810.1186/1752‑153X‑6‑97
    [Google Scholar]
  100. ThirunavukkarasuP. RamanathanT. Ram KumarL. ShanmugapriyaP. Anti-ulcer effect of Avicennia officinalis leaves in albino rats.World Appl. Sci. J.2010915558
    [Google Scholar]
  101. AyyanarM. Indian medicinal plants as a source of therapeutic agents: A review.Int. J. Biosoc. Res.201211124
    [Google Scholar]
  102. VenkatalakshmiP. SenthamaraiselviV. Anti-ulcer effect of Basella alba leaf extract in aspirin-induced albino rats.IJPSR20123825392542
    [Google Scholar]
  103. AkshathaK.N. MurthyS.M. LakshmideviN. Ethnomedical uses of Madhuca longifolia – A review.Int. J. Life Sci. Pharma Res.2013314453
    [Google Scholar]
  104. RajkapoorB. JayakarB. AnandanR. KavimaniS. Anti-ulcer effect of Bauhinia variegata Linn. in rats.J. Nat. Rem.200332215217
    [Google Scholar]
  105. SinghS. KhajuriaA. TanejaS.C. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.Phytomedicine2008156-740841510.1016/j.phymed.2008.02.017 18424019
    [Google Scholar]
  106. SwapnaP. RobertsonS. ElumalaiA. EswaraiahM.C. NirmalaK. Antiulcer activity of different plant extracts.IJPSR201121129382941
    [Google Scholar]
  107. GuliaY. ChoudharyM. Evaluation of antiulcer activity of Cassia tora leaf extract using ethanol-induced ulcer model in rats.Pharmacologyonline2011210381045
    [Google Scholar]
  108. KumarM. PaulY. AnandV.K. Ethnobotanical study of medicinal plants used by locals in Kishtwar, Jammu and Kashmir, India.Ethnobotanical Leaflets20091312401256
    [Google Scholar]
  109. KaruppusamyS. PullaiahT. Pollination system and ex situ fruit set in Ceropegia juncea Wight (Apocynaceae) – An endemic species of India.Asian J. Exp. Biol. Sci.200924242245
    [Google Scholar]
  110. NigamV. PaarakhP.M. Anti-ulcer effect of Chenopodium album Linn. against gastric ulcers in rats.Int. J. Pharm. Sci. Drug Res.201134319322
    [Google Scholar]
  111. AmrR. RezqA. ElmallahM. Anti-ulcer effect of cinnamon and chamomile aqueous extracts in rat models.J. Am. Sci.2010612209216
    [Google Scholar]
  112. RafatullahS. Al-YahyaM.A. Al-SaidM.S. TaraganK.U.A.H. MossaJ.S. Gastric anti-ulcer and cytoprotective effect of Cyamopsis tetragonoloba (‘Guar’) in rats.Int. J. Pharm.199432216317010.3109/13880209409082988
    [Google Scholar]
  113. MinaiyanM. GhannadiA. EtemadM. MahzouniP. A study of the effects of Cydonia oblonga Miller (Quince) on TNBS-induced ulcerative colitis in rats.Res. Pharm. Sci.201272103110 23181087
    [Google Scholar]
  114. VenkataswamyR. MohamadH.M. DossA. RaviT.K. SukumarM. Ethnobotanical study of medicinal plants by Malasar tribals in Coimbatore district of Tamil Nadu (South India).Asian J. Exp. Biol. Sci.201012387392
    [Google Scholar]
  115. PurohitM.G. ShanthaveerappaB.K. BadamiS. SwamyH.K.S. Antiulcer and anticatatonic activity of alcoholic extract of Evolvulus alsinoides (Convolvulaceae).Indian J. Pharm. Sci.1996583110112
    [Google Scholar]
  116. SalehA. MohammedA. TawfeqA. MohammedA. IbrahimA. SyedR. Gastric antiulcer activity of a pungent spice Ferula asafoetida in rats.Farmacia2011596750759
    [Google Scholar]
  117. PatilS.M. SainiR. Antiulcer activity of stem bark extract of Ficus bengalensis Linn. in rats.Am J Pharmtech Res201222349355
    [Google Scholar]
  118. ShenoyA.M. ShastryC.S. Antiulcer activity of Heliotropium indicum leaves extract.IJPSR201121161164
    [Google Scholar]
  119. ArsićI. ŽugićA. AntićD.R. Hypericum perforatum L. (Hypericaceae/Guttiferae) sunflower, olive, and palm oil extracts attenuate cold-resistant stress-induced gastric lesions.Molecules201015106688669810.3390/molecules15106688
    [Google Scholar]
  120. SathishR. VyawahareB. NatarajanK. Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats.J. Ethnopharmacol.2011134119519710.1016/j.jep.2010.11.049 21129476
    [Google Scholar]
  121. PatelP.K. PrajapatiN.K. DubeyB.K. Madhuca indica: A review of its medicinal property.IJPSR20123512851293
    [Google Scholar]
  122. KangJ.M. KimN. KimB. Enhancement of gastric ulcer healing and angiogenesis by Cochinchina momordica seed extract in rats.J. Korean Med. Sci.201025687588110.3346/jkms.2010.25.6.875 20514308
    [Google Scholar]
  123. GopalakrishananS. GC-MS analysis of some bioactive constituents of Mussaenda frondosa Linn.Int. J. Pharma Bio Sci.201121313320
    [Google Scholar]
  124. ShenoyA.M. ShastryC.S. Anti-ulcer activity of Naravelia zeylanica leaves extract.J. Pharm. Res.20092712181220
    [Google Scholar]
  125. VijayaraghavanR. GautamA. KumarO. Protective effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas.Indian J. Exp. Biol.20064410821831 17131913
    [Google Scholar]
  126. RachhadiyaR.M. KabraM.P. SheteR.V. Evaluation of antiulcer activity of castor oil in rats.IJRAP20112413491353
    [Google Scholar]
  127. ShahC. KumarS. BattiwalaA. Evaluation of anti-ulcer activity of Rosa centifolia (Linn.) flowers in experimental rats.J. Nat. Rem.20121212029
    [Google Scholar]
  128. HaliciM. OdabasogluF. SuleymanH. CakirA. AslanA. BayirY. Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats.Phytomedicine200512965666210.1016/j.phymed.2004.06.021 16194053
    [Google Scholar]
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