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2000
Volume 21, Issue 10
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder in which inflammation occurs in the synovial joint and synovial membrane, and in severe condition, it leads to erosion of cartilage and bone. The etiology of RA is still indescribable; generally, RA is a multifactorial disease, wherein complex interactions between patients and different factors such as environmental, genetic, and epigenetic factors determine the overall risk of disease. RA is classified based on the stage of disease. Treatment for RA is still a challenge for doctors and researchers. Effective treatment for RA can be achieved by decreasing disease activity or reduction of RA to other patients using currently available treatment options. This article gives a comprehensive perspective of data regarding different signaling pathways involved in RA development, factors affecting RA, stages of RA, and other treatments of RA. This article also suggests future research perspectives that would be helpful for the development of RA treatment (medicine) with more efficacy, safety profiles, and lower financial costs.

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References

  1. AbhishekA. DohertyM. KuoC.F. MallenC.D. ZhangW. GraingeM.J. Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study.Rheumatology (Oxford)2017565736744 28064207
     [Google Scholar]
  2. FishmanP. Bar-YehudaS. Rheumatoid arthritis: History, molecular mechanisms and therapeutic applications. A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics.Berlin, HeidelbergSpringer Link2010
     [Google Scholar]
  3. ChenC-Y. ChenJ. HeL. StilesB.L. PTEN: Tumor suppressor and metabolic regulator.Front. Endocrinol. (Lausanne)20189338 30038596
     [Google Scholar]
  4. SatheA. NawrothR. Targeting the PI3K/AKT/mTOR pathway in bladder cancer. Urothelial carcinoma.Methods Protoc.20182018335350
     [Google Scholar]
  5. NoortA.R. TakP.P. TasS.W. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?Arthritis Res. Ther.201517115 25774937
     [Google Scholar]
  6. ViatteS. MasseyJ. BowesJ. DuffusK. EyreS. BartonA. WorthingtonJ. Replication of associations of genetic loci outside the HLA region with susceptibility to anti–cyclic citrullinated peptide–negative rheumatoid arthritis.Arthritis Rheumatol.201668716031613 26895230
     [Google Scholar]
  7. ViatteS. PlantD. BowesJ. LuntM. EyreS. BartonA. WorthingtonJ. Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.Ann. Rheum. Dis.201271121984199010.1136/annrheumdis‑2011‑201225 22661644
     [Google Scholar]
  8. KrabbenA. HuizingaT.W. MilA.H. Biomarkers for radiographic progression in rheumatoid arthritis.Curr. Pharm. Des.2015212147169 25163742
     [Google Scholar]
  9. SokoloveJ. WagnerC.A. LaheyL.J. SaylesH. DuryeeM.J. ReimoldA.M. KerrG. RobinsonW.H. CannonG.W. ThieleG.M. MikulsT.R. Increased inflammation and disease activity among current cigarette smokers with rheumatoid arthritis: A cross-sectional analysis of US veterans.Rheumatology (Oxford)201655111969197710.1093/rheumatology/kew285 27477806
     [Google Scholar]
  10. SmolenJ.S. AletahaD. BartonA. BurmesterG.R. EmeryP. FiresteinG.S. KavanaughA. McInnesI.B. SolomonD.H. StrandV. YamamotoK. Rheumatoid arthritis.Nat. Rev. Dis. Primers2018411800110.1038/nrdp.2018.1 29417936
     [Google Scholar]
  11. SunK. LuoJ. GuoJ. YaoX. JingX. GuoF. The PI3K/AKT/mTOR signaling pathway in osteoarthritis: A narrative review.Osteoarthritis Cartilage2020284400409 32081707
     [Google Scholar]
  12. MiaoC.G. YangY.Y. HeX. LiX.F. HuangC. HuangY. ZhangL. LvX.W. JinY. LiJ. Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling.Cell. Signal.2013251020692078 23602936
     [Google Scholar]
  13. CiciD. CorradoA. RotondoC. CantatoreF.P. Wnt signaling and biological therapy in rheumatoid arthritis and spondyloarthritis.Int. J. Mol. Sci.201920225552 31703281
     [Google Scholar]
  14. AradhyaS. NelsonD.L. NF-kappaB signaling and human disease.Curr. Opin. Genet. Dev.2001113300306 11377967
     [Google Scholar]
  15. van LooG. BeyaertR. Negative regulation of NF-κB and its involvement in rheumatoid arthritis.Arthritis Res. Ther.2011133221 21639951
     [Google Scholar]
  16. WardwellP.R. ForstnerM.B. BaderR.A. Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models.Arthritis Res. Ther.201517310 26531309
     [Google Scholar]
  17. WinthropK.L. The emerging safety profile of JAK inhibitors in rheumatic disease.Nat. Rev. Rheumatol.2017134234243 28250461
     [Google Scholar]
  18. SimonL.S. The Jak/STAT pathway: A focus on pain in rheumatoid arthritis.Seminars in arthritis and rheumatism.AmsterdamElsevier2021
     [Google Scholar]
  19. XueC. YaoQ. GuX. ShiQ. YuanX. ChuQ. BaoZ. LuJ. LiL. Evolving cognition of the JAK-STAT signaling pathway: Autoimmune disorders and cancer.Signal Transduct. Target. Ther.202381204 37208335
     [Google Scholar]
  20. NahS.S. WonH.J. HaE. KangI. ChoH.Y. HurS.J. LeeS.H. BaikH.H. Epidermal growth factor increases prostaglandin E2 production via ERK1/2 MAPK and NF-κB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis.Rheumatol. Int.201030444344910.1007/s00296‑009‑0976‑6 19680656
     [Google Scholar]
  21. PaunovicV. HarnettM.M. Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis.Drugs2013732101115 23371304
     [Google Scholar]
  22. GeeE. MilkiewiczM. HaasT.L. p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis.J. Cell. Physiol.20102221120126 19774558
     [Google Scholar]
  23. MengW. ZhuZ. JiangX. TooC.L. UebeS. JagodicM. KockumI. MuradS. FerrucciL. AlfredssonL. ZouH. KlareskogL. FeinbergA.P. EkströmT.J. PadyukovL. LiuY. DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.Arthritis Res. Ther.201719171 28356135
     [Google Scholar]
  24. Frank-BertonceljM. TrenkmannM. KleinK. KarouzakisE. RehrauerH. BratusA. KollingC. ArmakaM. FilerA. MichelB.A. GayR.E. BuckleyC.D. KolliasG. GayS. OspeltC. Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions.Nat. Commun.2017811485210.1038/ncomms14852 28332497
     [Google Scholar]
  25. MillerJ.L. GrantP.A. The role of DNA methylation and histone modifications in transcriptional regulation in humans.Subcell. Biochem.201361289317
     [Google Scholar]
  26. PikwerM. BergströmU. NilssonJ.Å. JacobssonL. TuressonC. Early menopause is an independent predictor of rheumatoid arthritis.Ann. Rheum. Dis.2012713378381 21972241
     [Google Scholar]
  27. AdabP. JiangC.Q. RankinE. TsangY.W. LamT.H. BarlowJ. ThomasG.N. ZhangW.S. ChengK.K. Breastfeeding practice, oral contraceptive use and risk of rheumatoid arthritis among Chinese women: The Guangzhou Biobank Cohort Study.Rheumatology (Oxford)2014535860866 24395920
     [Google Scholar]
  28. KarlsonE.W. ChangS.C. CuiJ. ChibnikL.B. FraserP.A. De VivoI. CostenbaderK.H. Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis.Ann. Rheum. Dis.20106915460 19151010
     [Google Scholar]
  29. RosserE.C. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells.Cell Metab.2020314837851.e10
     [Google Scholar]
  30. PotempaJ. MydelP. KozielJ. The case for periodontitis in the pathogenesis of rheumatoid arthritis.Nat. Rev. Rheumatol.20171310606620 28835673
     [Google Scholar]
  31. TooC.L. MuhamadN.A. IlarA. PadyukovL. AlfredssonL. KlareskogL. MuradS. BengtssonC. Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study.Ann. Rheum. Dis.20167569971002 26681695
     [Google Scholar]
  32. StoltP. KällbergH. LundbergI. SjögrenB. KlareskogL. AlfredssonL. Silica exposure is associated with increased risk of developing rheumatoid arthritis: Results from the Swedish EIRA study.Ann. Rheum. Dis.200564458258610.1136/ard.2004.022053 15319232
     [Google Scholar]
  33. SalliotC. NguyenY. Boutron-RuaultM.C. SerorR. Environment and lifestyle: Their influence on the risk of RA.J. Clin. Med.20209103109 32993091
     [Google Scholar]
  34. SalgadoE. Bes-RastrolloM. de IralaJ. CarmonaL. Gómez-ReinoJ.J. High sodium intake is associated with self-reported rheumatoid arthritis: A cross sectional and case control analysis within the SUN cohort.Medicine (Baltimore)20159437e0924 26376372
     [Google Scholar]
  35. SongB. JinB. LiY. WangF. YangY. CuiY. SongX. YueZ. LiuJ. C19-norditerpenoid alkaloids from Aconitum szechenyianum.Molecules20182351108 29738430
     [Google Scholar]
  36. HeJ. WangY. FengM. ZhangX. JinY.B. LiX. SuL.C. LiuS. WangA.X. ChenX.M. WuL.J. YuX.X. XuN. LiuX.Y. YanH.M. WangY.F. JiaB. LiJ.F. TaoJ.M. ZhangF.X. YuP. CuiL.F. YangJ. LiZ.B. XieJ.L. WeiP. SunW.W. GongL. ChengY.J. HuangC.B. WangX.Y. WangY. GuoH.F. JinH.T. LiuX. WangG.C. WangY.H. HeL. ZhaoY. LiX.X. ZhangY. GuoJ.P. LiZ.G. Dietary intake and risk of rheumatoid arthritis—a cross section multicenter study.Clin. Rheumatol.201635122901290810.1007/s10067‑016‑3383‑x 27553386
     [Google Scholar]
  37. LuB. HirakiL.T. SparksJ.A. MalspeisS. ChenC.Y. AwosogbaJ.A. ArkemaE.V. CostenbaderK.H. KarlsonE.W. Being overweight or obese and risk of developing rheumatoid arthritis among women: A prospective cohort study.Ann. Rheum. Dis.2014731119141922 25057178
     [Google Scholar]
  38. LeeY.C. Agnew-BlaisJ. MalspeisS. KeyesK. CostenbaderK. KubzanskyL.D. RobertsA.L. KoenenK.C. KarlsonE.W. Post‐traumatic stress disorder and risk for incident rheumatoid arthritis.Arthritis Care Res. (Hoboken)201668329229810.1002/acr.22683 26239524
     [Google Scholar]
  39. DougadosM. SoubrierM. AntunezA. BalintP. BalsaA. BuchM.H. CasadoG. DetertJ. El-ZorkanyB. EmeryP. Hajjaj-HassouniN. HarigaiM. LuoS.F. KuruczR. MacielG. MolaE.M. MontecuccoC.M. McInnesI. RadnerH. SmolenJ.S. SongY.W. VonkemanH.E. WinthropK. KayJ. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: Results of an international, cross-sectional study (COMORA).Ann. Rheum. Dis.20147316268 24095940
     [Google Scholar]
  40. VallerandI.A. PattenS.B. BarnabeC. Depression and the risk of rheumatoid arthritis.Curr. Opin. Rheumatol.2019313279284 30789849
     [Google Scholar]
  41. BullockJ. RizviS.A.A. SalehA.M. AhmedS.S. DoD.P. AnsariR.A. AhmedJ. Rheumatoid arthritis: A brief overview of the treatment.Med. Princ. Pract.2018276501507 30173215
     [Google Scholar]
  42. OngC.K. LirkP. TanC.H. SeymourR.A. An evidence-based update on nonsteroidal anti-inflammatory drugs.Clin. Med. Res.2007511934 17456832
     [Google Scholar]
  43. CombeB. LandeweR. DaienC.I. HuaC. AletahaD. Álvaro-GraciaJ.M. BakkersM. BrodinN. BurmesterG.R. CodreanuC. ConwayR. DougadosM. EmeryP. FerraccioliG. FonsecaJ. RazaK. Silva-FernándezL. SmolenJ.S. SkingleD. SzekaneczZ. KvienT.K. van der Helm-van MilA. van VollenhovenR. 2016 update of the EULAR recommendations for the management of early arthritis.Ann. Rheum. Dis.2017766948959 27979873
     [Google Scholar]
  44. LiuD. AhmetA. WardL. KrishnamoorthyP. MandelcornE.D. LeighR. BrownJ.P. CohenA. KimH. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy.Allergy Asthma Clin. Immunol.20139130 23947590
     [Google Scholar]
  45. SuttonL.B. Naproxen Sodium: Pharmacists should counsel patients to determine whether self-medication with OTC NSAIDs is contraindicated.J. American Pharmaceut. Assoc.1996361166366710.1016/S1086‑5802(16)30151‑6
     [Google Scholar]
  46. UrsiniF. NatyS. BrunoC. GrembialeR.D. Old but good: Modified-release prednisone in rheumatoid arthritis.Rev. Recent Clin. Trials201712212412810.2174/1574887112666170328124539 28356031
     [Google Scholar]
  47. SmolenJ.S. LandewéR. BreedveldF.C. DougadosM. EmeryP. Gaujoux-VialaC. GorterS. KnevelR. NamJ. SchoelsM. AletahaD. BuchM. GossecL. HuizingaT. BijlsmaJ.W.J.W. BurmesterG. CombeB. CutoloM. GabayC. Gomez-ReinoJ. KouloumasM. KvienT.K. Martin-MolaE. McInnesI. PavelkaK. van RielP. ScholteM. ScottD.L. SokkaT. ValesiniG. van VollenhovenR. WinthropK.L. WongJ. ZinkA. van der HeijdeD. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs.Ann. Rheum. Dis.201069696497510.1136/ard.2009.126532 20444750
     [Google Scholar]
  48. LuoQ. SunY. LiuW. QianC. JinB. TaoF. GuY. WuX. ShenY. XuQ. A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.J. Immunol.20131911049694978 24123677
     [Google Scholar]
  49. DaleJ. AlcornN. CapellH. MadhokR. Combination therapy for rheumatoid arthritis: Methotrexate and sulfasalazine together or with other DMARDs.Nat. Clin. Pract. Rheumatol.20073845045810.1038/ncprheum0562 17664952
     [Google Scholar]
  50. SmolenJ.S. EmeryP. KaldenJ.R. Van RielP.L. DougadosM. StrandC.V. BreedveldF.C. The efficacy of leflunomide monotherapy in rheumatoid arthritis: Towards the goals of disease modifying antirheumatic drug therapy.J. Rheumatol. Suppl.2004711320 15170903
     [Google Scholar]
  51. DhillonS. Tofacitinib: A review in rheumatoid arthritis.Drugs2017771819872001 29139090
     [Google Scholar]
  52. TaylorP.C. KeystoneE.C. van der HeijdeD. WeinblattM.E. Del Carmen MoralesL. Reyes GonzagaJ. YakushinS. IshiiT. EmotoK. BeattieS. AroraV. GaichC. RooneyT. SchlichtingD. MaciasW.L. de BonoS. TanakaY. Baricitinib versus placebo or adalimumab in rheumatoid arthritis.N. Engl. J. Med.20173767652662 28199814
     [Google Scholar]
  53. FrenchJ.B. BonaciniM. GhabrilM. FoureauD. BonkovskyH.L. Hepatotoxicity associated with the use of anti-TNF-α agents.Drug Saf.2016393199208 26692395
     [Google Scholar]
  54. GabayC. EmeryP. Van VollenhovenR. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial.Lancet201338198771540 23602231
     [Google Scholar]
  55. KasiP.M. TawbiH.A. OddisC.V. KulkarniH.S. Clinical review: Serious adverse events associated with the use of rituximab - a critical care perspective.Crit. Care2012164231 22967460
     [Google Scholar]
  56. MaxwellL. SinghJ.A. Abatacept for rheumatoid arthritis.Cochrane Database Syst. Rev.200920094CD007277
     [Google Scholar]
  57. DaienC.I. HuaC. CombeB. LandeweR. Non-pharmacological and pharmacological interventions in patients with early arthritis: A systematic literature review informing the 2016 update of EULAR recommendations for the management of early arthritis.RMD Open201731e000404 28151539
     [Google Scholar]
  58. InoueK. YuasaH. Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy.Drug Metab. Pharmacokinet.20142911219 24284432
     [Google Scholar]
  59. HaskóG. LindenJ. CronsteinB. PacherP. Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases.Nat. Rev. Drug Discov.200879759770 18758473
     [Google Scholar]
  60. MontesinosM.C. DesaiA. DelanoD. ChenJ.F. FinkJ.S. JacobsonM.A. CronsteinB.N. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.Arthritis Rheum.2003481240247 12528125
     [Google Scholar]
  61. TianH. CronsteinB.N. Understanding the mechanisms of action of methotrexate: Implications for the treatment of rheumatoid arthritis.Bull. NYU Hosp. Jt. Dis.2007653168173 17922664
     [Google Scholar]
  62. KremerJ.M. Use of methotrexate in the treatment of rheumatoid arthritis.Waltham, MAWalters Kluwer2019
     [Google Scholar]
  63. da SilvaJ.C. MarizH.A. da Rocha JúniorL.F. Santana de OliveiraP.S. DantasA.T. DuarteA.L.B.P. da Rocha PittaI. GaldinoS.L. da Rocha PittaM.G. Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients.Clinics (São Paulo)201368676677110.6061/clinics/2013(06)07 23778483
     [Google Scholar]
  64. SchrezenmeierE. DörnerT. Mechanisms of action of hydroxychloroquine and chloroquine: Implications for rheumatology.Nat. Rev. Rheumatol.2020163155166 32034323
     [Google Scholar]
  65. RodenburgR. The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor a expression in macrophages by inducing apoptis.Arthritis Rheum.200043919411950
     [Google Scholar]
  66. HirohataS. OhshimaN. YanagidaT. AramakiK. Regulation of human B cell function by sulfasalazine and its metabolites.Int. Immunopharmacol.200225631640 12013503
     [Google Scholar]
  67. HerrmannM.L. SchleyerbachR. KirschbaumB.J. Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases.Immunopharmacology2000472-327328910.1016/S0162‑3109(00)00191‑0 10878294
     [Google Scholar]
  68. GibofskyA. Combination therapy for rheumatoid arthritis in the era of biologicals.HSS J.2006213041 18751844
     [Google Scholar]
  69. MusumeciF. GrecoC. GiacchelloI. FallacaraA.L. IbrahimM.M. GrossiG. BrulloC. SchenoneS. An update on JAK inhibitors.Curr. Med. Chem.201926101806183210.2174/0929867325666180327093502 29589523
     [Google Scholar]
  70. RouxC.H. BrocqO. BreuilV. AlbertC. Euller-ZieglerL. Safety of anti-TNF-α therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis.Rheumatology (Oxford)2006451012941297 16603583
     [Google Scholar]
  71. van SchouwenburgP.A. RispensT. WolbinkG.J. Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis.Nat. Rev. Rheumatol.20139316417210.1038/nrrheum.2013.4 23399692
     [Google Scholar]
  72. KatzungB.G. Basic and clinical pharmacology.14th edNew York, United StatesMcGraw Hill Professional2017
     [Google Scholar]
  73. PerpétuoI.P. Caetano-LopesJ. RodriguesA.M. Campanilho-MarquesR. PonteC. CanhãoH. AinolaM. FonsecaJ.E. Effect of tumor necrosis factor inhibitor therapy on osteoclasts precursors in rheumatoid arthritis.BioMed Res. Int.20172017111010.1155/2017/2690402 28286757
     [Google Scholar]
  74. DesaiR.J. HansenR.A. RaoJ.K. WilkinsT.M. HardenE.A. YuenA. JonasD.E. RoubeyR. JonasB. GartlehnerG. LuxL. DonahueK.E. Mixed treatment comparison of the treatment discontinuations of biologic disease-modifying antirheumatic drugs in adults with rheumatoid arthritis.Ann. Pharmacother.2012461114911505 23092868
     [Google Scholar]
  75. KumarV. Fostered antiarthritic upshot of moringa oleifera lam. stem bark extract in diversely induced arthritis in wistar rats with plausible mechanism.Int. J. Pharm. Sci. Res.20134103894
     [Google Scholar]
  76. LouieG.H. WardM.M. Changes in the rates of joint surgery among patients with rheumatoid arthritis in California, 1983-2007.Ann. Rheum. Dis.2010695868871 19581279
     [Google Scholar]
  77. ChungK.C. PushmanA.G. Current concepts in the management of the rheumatoid hand.J. Hand Surg. Am.2011364736747 21463736
     [Google Scholar]
  78. BarchiE.I. SwensenS. DimantO.E. McKayT.E. RoseD.J. Flexor hallucis longus tenolysis and tenosynovectomy in dancers.J. Foot Ankle Surg.20226118487 34301473
     [Google Scholar]
  79. KnutL. Radiosynovectomy in the therapeutic management of arthritis.World J. Nucl. Med.20151411015 25709538
     [Google Scholar]
  80. PudduG. CipollaM. CerulloG. FrancoV. GiannìE. Which osteotomy for a valgus knee?Int. Orthop.201034223924710.1007/s00264‑009‑0820‑3 19547972
     [Google Scholar]
  81. PajarinenJ. LinT.H. SatoT. YaoZ. GoodmanS.B. Interaction of materials and biology in total joint replacement–successes, challenges and future directions.J. Mater. Chem. B Mater. Biol. Med.201424170947108 25541591
     [Google Scholar]
  82. Escott-StumpS. Nutrition and diagnosis-related care.PhiladelphiaLippincott Williams & Wilkins2008
     [Google Scholar]
  83. CooneyJ.K. LawR.J. MatschkeV. LemmeyA.B. MooreJ.P. AhmadY. JonesJ.G. MaddisonP. ThomJ.M. Benefits of exercise in rheumatoid arthritis.J. Aging Res.201120111681640 21403833
     [Google Scholar]
  84. BurskaA.N. RogetK. BlitsM. Soto GomezL. van de LooF. HazelwoodL.D. VerweijC.L. RoweA. GoulielmosG.N. van BaarsenL.G.M. PonchelF. Gene expression analysis in RA: Towards personalized medicine.Pharmacogenomics J.20141429310610.1038/tpj.2013.48 24589910
     [Google Scholar]
  85. González-ÁlvaroI. OrtizA.M. SeoaneI.V. García-VicuñaR. MartínezC. GomarizR.P. Biomarkers predicting a need for intensive treatment in patients with early arthritis.Curr. Pharm. Des.201421217018110.2174/1381612820666140825123104 25163741
     [Google Scholar]
  86. RavikumarC. Herbal Remedy for Rheumatoid Arthritis.J. Pharmaceut. Sci. Res.201469310
     [Google Scholar]
  87. FarinonM. ClarimundoV.S. PedrazzaG.P.R. GulkoP.S. ZuanazziJ.A.S. XavierR.M. de OliveiraP.G. Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes.Eur. J. Pharmacol.201779918018710.1016/j.ejphar.2017.02.013 28192100
     [Google Scholar]
  88. RiehemannK. BehnkeB. Schulze-OsthoffK. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB.FEBS Lett.199944218994 9923611
     [Google Scholar]
  89. JoshiB.C. MukhijaM. KaliaA.N. Pharmacognostical review of Urtica dioica L.Int. J. Green Pharm.201484
     [Google Scholar]
  90. LuoX. LiL.L. ZhangS.S. LuJ.L. ZengY. ZhangH.Y. XiangM. Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice.J. Ethnopharmacol.2011138252352910.1016/j.jep.2011.09.050 22001857
     [Google Scholar]
  91. Sanmuga PriyaE. VenkataramanS. Anti-inflammatory effect of Strychnos potatorum. seeds on acute and subacute inflammation in experimental rat models.Pharm. Biol.200745643543910.1080/13880200701388922
     [Google Scholar]
  92. EkambaramS.P. PerumalS.S. SubramanianV. Strychnos potatorum Linn Seed Extract Enhances Lysosomal Membrane Stability and Collagen Formation in Freunds Complete Adjuvant-Induced Arthritic Rats.J. Herbs Spices Med. Plants2011174392402
     [Google Scholar]
  93. VetalS. BodhankarS.L. MohanV. ThakurdesaiP.A. Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats.Food Sci. Hum. Wellness201322596710.1016/j.fshw.2013.03.003
     [Google Scholar]
  94. ZhangC. FanL. FanS. WangJ. LuoT. TangY. ChenZ. YuL. Cinnamomum cassia Presl: A review of its traditional uses, phytochemistry, pharmacology and toxicology.Molecules20192419347310.3390/molecules24193473 31557828
     [Google Scholar]
  95. HanX. ParkerT.L. Antiinflammatory activity of cinnamon (Cinnamomum zeylanicum) bark essential oil in a human skin disease model.Phytother. Res.201731710341038 28444928
     [Google Scholar]
  96. LiaoJ-C. DengJ.S. ChiuC.S. HouW.C. HuangS.S. ShieP.H. HuangG.J. Anti‐inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo.Evid. Based Complement. Alternat. Med.201220121429320 22536283
     [Google Scholar]
  97. LiuP. WangJ. WenW. PanT. ChenH. FuY. WangF. HuangJ.H. XuS. Cinnamaldehyde suppresses NLRP3 derived IL-1β via activating succinate/HIF-1 in rheumatoid arthritis rats.Int. Immunopharmacol.20208410657010.1016/j.intimp.2020.106570 32413739
     [Google Scholar]
  98. MoutiaM. SeghrouchniF. AbouelazzO. ElouaddariA. Al JahidA. ElhouA. NadifiS. Jamal EddineJ. HabtiN. BadouA. Allium sativum L. regulates in vitro IL-17 gene expression in human peripheral blood mononuclear cells.BMC Complement. Altern. Med.201616137710.1186/s12906‑016‑1365‑9 27681382
     [Google Scholar]
  99. MoosavianS.P. PaknahadZ. HabibagahiZ. MaracyM. The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled trial.Phytother. Res.202034112953296210.1002/ptr.6723 32478922
     [Google Scholar]
  100. AimanU. Anti-arthritic effect of onion skin extract on rat complete freund’s adjuvant-induced.Eur. J. Mol. Clin. Med.202077e230
     [Google Scholar]
  101. WuT.T. TsaiC.W. YaoH.T. LiiC.K. ChenH.W. WuY.L. ChenP.Y. LiuK.L. Suppressive effects of extracts from the aerial part of Coriandrum sativum L. on LPS-induced inflammatory responses in murine RAW 264.7 macrophages.J. Sci. Food Agric.201090111846185410.1002/jsfa.4023 20549653
     [Google Scholar]
  102. NairV. SinghS. GuptaY.K. Anti-granuloma activity of Coriandrum sativum in experimental models.J. Ayurveda Integr. Med.2013411318 23741156
     [Google Scholar]
  103. BhatS.P. Waseem RizviW.R. Anil KumarA.K. Coriandrum sativum on pain and inflammation.IJRPC201444939945
     [Google Scholar]
  104. FunkJ.L. FryeJ.B. OyarzoJ.N. ZhangH. TimmermannB.N. Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).J. Agric. Food Chem.201058284284910.1021/jf9027206 20025215
     [Google Scholar]
  105. ZouS. WangC. CuiZ. GuoP. MengQ. ShiX. GaoY. YangG. HanZ. β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase.Pharmacol. Rep.2016681711 26721344
     [Google Scholar]
  106. PanM.H. HsiehM.C. KuoJ.M. LaiC.S. WuH. SangS. HoC.T. 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression.Mol. Nutr. Food Res.2008525527537 18384088
     [Google Scholar]
  107. JungH.W. YoonC.H. ParkK.M. HanH.S. ParkY.K. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway.Food Chem. Toxicol.200947611901197 19233241
     [Google Scholar]
  108. FunkJ.L. FryeJ.B. OyarzoJ.N. TimmermannB.N. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis.J. Nat. Prod.2009723403407 19216559
     [Google Scholar]
  109. FunkJ.L. FryeJ.B. OyarzoJ.N. ChenJ. ZhangH. TimmermannB.N. Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis.PharmaNutrition20164312313110.1016/j.phanu.2016.02.004 27872812
     [Google Scholar]
  110. FoudaA.M.M. BerikaM.Y. Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis.Basic Clin. Pharmacol. Toxicol.2009104326227110.1111/j.1742‑7843.2008.00363.x 19175367
     [Google Scholar]
  111. MuC-X. [Effect of Tetramethyl pyrazine on serum levels of IL-1beta, IL-6, and IL-2, and NO and PGE2 in the synovial fluid of CIA rats: An experimental research].Zhongguo Zhong Xi Yi Jie He Za Zhi2014342214217
     [Google Scholar]
  112. KimH.M. KimY.M. HuhJ.H. LeeE.S. KwonM.H. LeeB.R. KoH.J. ChungC.H. α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2.PLoS One2017126e017920410.1371/journal.pone.0179204 28598982
     [Google Scholar]
  113. LeeL.T. TsaiY-F. HuN-Y. WangC-W. HuangK-K. HsiaoJ-K. ShihY-C. MunekazuI. Anti-arthritis effect of mangostins from G. Mangostana. Biomed.Prev. Nutr.20133322723210.1016/j.bionut.2012.10.002
     [Google Scholar]
  114. FuY. ZhouH. WangM. CenJ. WeiQ. Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana L. against collagen-induced arthritis.J. Agric. Food Chem.201462184127413410.1021/jf405790q 24738849
     [Google Scholar]
  115. GolechhaM. SarangalV. OjhaS. BhatiaJ. AryaD.S. Anti-inflammatory effect of emblica officinalis in rodent models of acute and chronic inflammation: Involvement of possible mechanisms.Int. J. Inflamm.201420141178408 25215258
     [Google Scholar]
  116. SunH. WangM. ZhangA. NiB. DongH. WangX. UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach.Phytochem. Anal.201324326327610.1002/pca.2407 23225552
     [Google Scholar]
  117. GaiW. HaoX. ZhaoJ. WangL. LiuJ. JiangH. JinH. LiuG. FengY. Delivery of benzoylaconitine using biodegradable nanoparticles to suppress inflammation via regulating NF-κB signaling.Colloids Surf. B Biointerfaces202019111098010.1016/j.colsurfb.2020.110980 32252000
     [Google Scholar]
  118. YuH.H. LiM. LiY.B. LeiB.B. YuanX. XingX.K. XieY.F. WangM. WangL. YangH.J. FengZ.W. ChengB.F. Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.Biol. Pharm. Bull.202043233433910.1248/bpb.b19‑00719 31735734
     [Google Scholar]
  119. JangM. JeongS.W. ChoS.K. AhnK.S. LeeJ.H. YangD.C. KimJ.C. Anti-inflammatory effects of an ethanolic extract of guava (Psidium guajava L.) leaves in vitro and in vivo.J. Med. Food201417667868510.1089/jmf.2013.2936 24738717
     [Google Scholar]
  120. BarorohH.N. UtamiE.D. AchmadA. Psidium guajava leaves decrease arthritic symptoms in adjuvant-induced arthritic rats.Universa Medicina201634319720410.18051/UnivMed.2015.v34.197‑204
     [Google Scholar]
  121. MahdiH.J. In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund’s adjuvant (CFA)-induced arthritis in rats.Integr. Med. Res.201871859410.1016/j.imr.2017.11.002 29629295
     [Google Scholar]
  122. MahajanS.G. MaliR.G. MehtaA.A. Protective effect of ethanolic extract of seeds of Moringa oleifera Lam. against inflammation associated with development of arthritis in rats.J. Immunotoxicol.200741394710.1080/15476910601115184 18958711
     [Google Scholar]
  123. LiuY. LiM. HeQ. YangX. RuanF. SunG. Periploca forrestii saponin ameliorates murine CFA‐induced arthritis by suppressing cytokine production.Mediators Inflamm.2016201617941684 28057980
     [Google Scholar]
  124. HuangM. Effects and molecular mechanism of Periploca forrestii against rheumatoid arthritis.Zhongguo Shiyan Fangjixue Zazhi201117174177
     [Google Scholar]
  125. LiuT. WangX. HeY.L. WangY. DongL. MaX. ZhengL. LiuC.H. WangG.C. ZhengJ. LanY.Y. LiY.J. In vivo and in vitro anti-arthritic effects of cardenolide-rich and caffeoylquinic acid-rich fractions of Periploca forrestii.Molecules2018238198810.3390/molecules23081988 30096961
     [Google Scholar]
  126. LiangJ. Effects of Periploca forrestii ethanol extract (PFE) on proliferation, COX-2 expression, and PG2 expression of rheumatoid arthritis synovial fibroblasts from patients.Lishizhen Med. Mater. Med. Res2015262427
     [Google Scholar]
  127. GuoY. YeQ. YangS. WuJ. YeB. WuY. HuangZ. ZhengC. Therapeutic effects of polysaccharides from Anoectochilus roxburghii on type II collagen-induced arthritis in rats.Int. J. Biol. Macromol.201912288289210.1016/j.ijbiomac.2018.11.015 30408452
     [Google Scholar]
  128. BaoJ. DaiS.M. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: Mechanism, efficacy, and safety.Rheumatol. Int.20113191123112910.1007/s00296‑011‑1841‑y 21365177
     [Google Scholar]
  129. TaoX.L. SunY. DongY. XiaoY.L. HuD.W. ShiY.P. ZhuQ.L. DaiH. ZhangN.Z. A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis.Chin. Med. J. (Engl.)19891025327332 2509153
     [Google Scholar]
  130. TaoX. YoungerJ. FanF.Z. WangB. LipskyP.E. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double‐blind, placebo‐controlled study.Arthritis Rheum.20024671735174310.1002/art.10411 12124856
     [Google Scholar]
/content/journals/cbc/10.2174/0115734072317179240919081449
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Exploring Rheumatoid Arthritis: Unraveling Signaling Pathways, Advancing Management, and Charting Future Perspectives
Curr. Bioact. Compd. 21, E15734072317179 (2025); https://doi.org/10.2174/0115734072317179240919081449
/content/journals/cbc/10.2174/0115734072317179240919081449
/content/journals/cbc/10.2174/0115734072317179240919081449
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  • Article Type:     Review Article
Keyword(s): citrullinated protein; epigenetic factors; inflammation; Rheumatoid arthritis; signaling pathway; synovial membrane

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