Skip to content
2000
Volume 21, Issue 7
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Background

One of the (Leguminosae) species with remarkable pharmacological and biological properties is , which has been utilized in traditional medicine. Very little study has been conducted on this species thus far. The purpose of this study was to examine the anti-microbial and antioxidant properties of two distinct extracts of aerial parts (n-butanol and ethyl acetate) as well as an ethyl acetate extract of the root.

Methods

Each extract's ability to scavenge the free radicals of DPPH was used to express the antioxidant property. Gram-positive and gram-negative bacteria, such as , , , and , were spread to assess the extract's antimicrobial properties.

Results

The aerial portions' n-butanol extract (IC = 0.92 µg/mL) demonstrated excellent antioxidant properties. The microorganisms that responded to the root's ethyl acetate extract the most were (MIC = 1 µg/mL).

Conclusion

This study's findings demonstrated that has strong antibacterial and antioxidant properties, which allow for its application as a natural antioxidant or antibiotic in a variety of pharmaceutical formulations for the prevention of cancer.

Loading

Article metrics loading...

/content/journals/cbc/10.2174/0115734072310658240822045329
2024-09-02
2025-08-18
Loading full text...

Full text loading...

References

  1. HuangR. ZhouP.K. DNA damage repair: Historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.Signal Transduct. Target. Ther.20216125428810.1038/s41392‑021‑00648‑734238917
    [Google Scholar]
  2. MarkiewiczE. IdowuO.C. DNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling.Open Biol.201991219020819021910.1098/rsob.19020831847786
    [Google Scholar]
  3. KaurP. PurewalS.S. SandhuK.S. KaurM. DNA damage protection: An excellent application of bioactive compounds.Bioresour. Bioprocess.201961210.1186/s40643‑019‑0237‑9
    [Google Scholar]
  4. KashyapD. TuliH.S. YererM.B. SharmaA. SakK. SrivastavaS. PandeyA. GargV.K. SethiG. BishayeeA. Natural product-based nanoformulations for cancer therapy: Opportunities and challenges.Semin. Cancer Biol.20216952310.1016/j.semcancer.2019.08.01431421264
    [Google Scholar]
  5. Jamshidi-KiaF. LorigooiniZ. Amini-KhoeiH. Medicinal plants: Past history and future perspective.J. Herbmed Pharmacol.2018711710.15171/jhp.2018.01
    [Google Scholar]
  6. SonboliA. MirzaniaF. AliahmadiA. AmiriM.S. Composition and antibacterial activity of the essential oil of Phlomidoschema parviflorum from Iran.Chem. Nat. Compd.201551236636810.1007/s10600‑015‑1286‑8
    [Google Scholar]
  7. MirzaniaF. FarimaniM.M. Biochemical evaluation of antioxidant activity, phenol and flavonoid contents of Dracocephalum kotschyiBoiss extracts obtained with different solvents.HBB201813244
    [Google Scholar]
  8. NguyenH.C. ChenC.C. LinK.H. ChaoP.Y. LinH.H. HuangM.Y. Bioactive compounds, antioxidants, and health benefits of sweet potato leaves.Molecules20212671820182910.3390/molecules2607182033804903
    [Google Scholar]
  9. HanY. ChiJ. ZhangM. ZhangR. FanS. HuangF. XueK. LiuL. Characterization of saponins and phenolic compounds: antioxidant activity and inhibitory effects on α-glucosidase in different varieties of colored quinoa ( Chenopodium quinoa Willd).Biosci. Biotechnol. Biochem.201983112128213910.1080/09168451.2019.163875631282254
    [Google Scholar]
  10. Guajardo-FloresD. Serna-SaldívarS.O. Gutiérrez-UribeJ.A. Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).Food Chem.201314121497150310.1016/j.foodchem.2013.04.01023790944
    [Google Scholar]
  11. LuoB. LiF. AhmedS. LongC. Diversity and use of medicinal plants for soup making in traditional diets of the Hakka in West Fujian, China.J. Ethnobiol. Ethnomed.20191516010.1186/s13002‑019‑0335‑y31779654
    [Google Scholar]
  12. RoomiM.W. NiedzwieckiA. RathM. Scientific evaluation of dietary factors in cancer.J. Nutri. Med. Diet Care.20184029113
    [Google Scholar]
  13. Abd El-GhaniM.M. El-SayedA.S. MoubarakA. RashadR. NosierH. KhattabA. Biosystematic study on some Egyptian species of Astragalus L. (Fabaceae).Agric2021112125136
    [Google Scholar]
  14. ShahrajabianM.H. SunW. ChengQ. A review of Astragalus species as foodstuffs, dietary supplements, a traditional chinese medicine and a part of modern pharmaceutical science.Appl. Ecol. Environ. Res.2019176133711338210.15666/aeer/1706_1337113382
    [Google Scholar]
  15. Clement-KruzelS. HwangS.A. KruzelM.C. DasguptaA. ActorJ.K. Immune modulation of macrophage pro-inflammatory response by goldenseal and Astragalus extracts.J. Med. Food200811349349810.1089/jmf.2008.004418800897
    [Google Scholar]
  16. Ghasemian-YadegariJ. MirzaniaF. Fard ArdaliJ.K. NikbakhtM.R. RashidipourM. NouraieH. SikevandiS.J. RadM.T. Evaluation of antioxidant, mutagenicity, and anti-mutagenicity potential of Astragalus gossypinus Fisch. extracts.Curr. Bioact. Compd.2023193e10052220454810.2174/1573407218666220510145320
    [Google Scholar]
  17. PistelliL.F. Secondary metabolites of genus Astragalus: Structure and biological activity.Studies in Natural Products Chemistry20022744354510.1016/S1572‑5995(02)80043‑6
    [Google Scholar]
  18. AlrummanS.A. MoustafaM.F. AlamriS.A. Antibacterial and anti-fungal investigation of Astragalus atropilosulus subsp. abyssinicus.Afr. J. Microbiol. Res.20126346365636910.5897/AJMR12.778
    [Google Scholar]
  19. Ghasemian-YadegariJ. HamedeyazdanS. NazemiyehH. FathiazadF. Evaluation of phytochemical, antioxidant and antibacterial activity on Astragalus chrysostachys Boiss. roots.Iran. J. Pharm. Res.20191841902191132184856
    [Google Scholar]
  20. ChengR.B. ChenX. LiuS.J. ZhangX.F. ZhangG.H. Experimental study of the inhibitory effects of Chelidonium majus L. extractive on Streptococcus mutans in vitro..Shanghai Kou Qiang Yi Xue200615331832016862371
    [Google Scholar]
  21. KüçükM. KolaylıS. KaraoğluŞ. UlusoyE. BaltacıC. CandanF. Biological activities and chemical composition of three honeys of different types from Anatolia.Food Chem.2007100252653410.1016/j.foodchem.2005.10.010
    [Google Scholar]
  22. HrašA.R. HadolinM. KnezŽ. BaumanD. Comparison of antioxidative and synergistic effects of rosemary extract with α-tocopherol, ascorbyl palmitate and citric acid in sunflower oil.Food Chem.200071222923310.1016/S0308‑8146(00)00161‑8
    [Google Scholar]
  23. TeyebH. ZaninaN. NeffatiM. DoukiW. NajjarM.F. Cytotoxic and antibacterial activities of leaf extracts of Astragalus gombiformis Pomel (Fabaceae) growing wild in Tunisia.Turk. J. Biol.2012361535810.3906/biy‑1010‑131
    [Google Scholar]
  24. JaradatN.A. ZaidA.N. AbuzantA. KhalafS. Abu-HassanN. Phytochemical and biological properties of four Astragalus species commonly used in traditional Palestinian medicine.Eur. J. Integr. Med.201791810.1016/j.eujim.2017.01.008
    [Google Scholar]
  25. AdigüzelA. SökmenM. ÖzkanH. AğarG. GüllüceM. ŞahınF. In vitro antimicrobial and antioxidant activities of methanol and hexane extract of Astragalus species growing in the eastern Anatolia region of Turkey.Turk. J. Biol.2009331657110.3906/biy‑0805‑1
    [Google Scholar]
  26. KanaanH. ElMestrahM. SweidanA. AssadiF. BazzalA. ChokrA. Screening for antibacterial and antibiofilm activities in Astragalus angulosus. J. Intercult. Ethnopharmacol.201761505710.5455/jice.2016101810172028163960
    [Google Scholar]
  27. ReuterS. GuptaS.C. ChaturvediM.M. AggarwalB.B. Oxidative stress, inflammation, and cancer: How are they linked?Free Radic. Biol. Med.201049111603161610.1016/j.freeradbiomed.2010.09.00620840865
    [Google Scholar]
  28. KeypourS. MirzaniaF. FarimaniM.M. Antioxidant activity, total flavonoid and phenolic contents of three different extracts of Hyrcanian reishi .Curr. Bioact. Compd.201915110911310.2174/1573407213666171107151007
    [Google Scholar]
  29. BorneoR. LeónA.E. AguirreA. RibottaP. CanteroJ.J. Antioxidant capacity of medicinal plants from the Province of Córdoba (Argentina) and their in vitro testing in a model food system.Food Chem.2009112366467010.1016/j.foodchem.2008.06.027
    [Google Scholar]
  30. WongB.Y.Y. LauB.H.S. TadiP.P. TeelR.W. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of aflatoxin B1.Mutat. Res. Genet. Toxicol. Test.1992279320921610.1016/0165‑1218(92)90069‑C1377337
    [Google Scholar]
  31. Vera-RamirezL. Sanchez-RoviraP. Ramirez-TortosaM.C. Ramirez-TortosaC.L. Granados-PrincipalS. LorenteJ.A. QuilesJ.L. Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies.Crit. Rev. Oncol. Hematol.201180334736810.1016/j.critrevonc.2011.01.00421288735
    [Google Scholar]
  32. TuY. WangY. XUC. YaoG. ShanT. Effect of Astragalus and Astragalus polysaccharide on antimicrobial peptides PR-39 and protegrin-1 gene expression in pigs.Turk. J. Vet. Anim. Sci.2006303325330
    [Google Scholar]
  33. HaoB. XingX. WuF. XiangH. WenF. HuY. LiangJ. Study on the anti-bovine viral diarrhea virus effect of swainsonine extract of Astragalus strictus Grah Ex Bend in vitro. Indian J. Anim. Res.2019531216661670
    [Google Scholar]
  34. JeeJ.P. LimS.J. ParkJ.S. KimC.K. Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles.Eur. J. Pharm. Biopharm.200663213413910.1016/j.ejpb.2005.12.00716527470
    [Google Scholar]
  35. ChunS.S. VattemD.A. LinY.T. ShettyK. Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochem.200540280981610.1016/j.procbio.2004.02.018
    [Google Scholar]
  36. ÇoruhN. Sagˇdıçogˇlu CelepA.G. ÖzgökçeF. İşcanM. Antioxidant capacities of Gundelia tournefortii L. extracts and inhibition on glutathione-S-transferase activity.Food Chem.200710031249125310.1016/j.foodchem.2005.12.008
    [Google Scholar]
  37. EbrahimiS. FarimaniM.M. MirzaniaF. HamburgerM. New sesterterpenoids from Salvia mirzayanii - Stereochemical characterization by computational electronic circular dichroism.Planta Med.20137913PG210.1055/s‑0033‑1352072
    [Google Scholar]
  38. KhorshidiN. RahimiM. SalimikiaI. Application of aeration‐assisted homogeneous liquid–liquid microextraction procedure using Box–Behnken design for determination of curcumin by HPLC.J. Sep. Sci.202043132513252010.1002/jssc.20200000132255267
    [Google Scholar]
  39. BaderM.S. LoebM. LetoD. BrooksA.A. Treatment of urinary tract infections in the era of antimicrobial resistance and new antimicrobial agents.Postgrad. Med.2020132323425010.1080/00325481.2019.168005231608743
    [Google Scholar]
  40. MirzaniaF. Moridi FarimaniM. SarrafiY. Nejad EbrahimiS. TroppmairJ. KwiatkowskiM. StuppnerH. AlilouM. New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical characterization by computational electronic circular dichroism.Front Chem.2022978329210.3389/fchem.2021.78329235127644
    [Google Scholar]
  41. MirzaniaF. SonboliA. Chemical diversity of essential oil composition from five populations of Dracocephalum kotschyi Boiss.HBB2021513950
    [Google Scholar]
  42. Jinous Asgarpanah MotamedS.M. FarzanehA. GhanizadehB. TomraeeS. Antioxidant activity and total phenolic and flavonoid content of Astragalus squarrosus Bunge.Afr. J. Biotechnol.20111082191761918010.5897/AJB11.3073
    [Google Scholar]
  43. TedjaniA. BoualZ. TelliA. ChemsaA.E. KhelefY. Ethnobotanical survey of two astragalus species used by the local population in El-Oued province (septentrional Algerian Sahara).Vegetos202331110.1007/s42535‑023‑00755‑6
    [Google Scholar]
  44. AhmadN. RiazS. AliA. RiazT. Fenugreek (Trigonella foenum-graecum ): An overview of food uses and health benefits.Neglected Plant Foods Of South Asia202345347110.1007/978‑3‑031‑37077‑9_18.
    [Google Scholar]
  45. BettsT.J. The detection of possible toxic constituents in plant material.Toxicon198321414410.1016/0041‑0101(83)90150‑2
    [Google Scholar]
  46. WinkM. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective.Phytochemistry200364131910.1016/S0031‑9422(03)00300‑512946402
    [Google Scholar]
  47. WinkM. Evolution of secondary metabolites in legumes (Fabaceae).S. Afr. J. Bot.20138916417510.1016/j.sajb.2013.06.006
    [Google Scholar]
  48. HendersonC.B. The influence of seed apparency, nutrient content and chemical defenses on dietary preference in Dipodomys ordii. Oecologia199082333334110.1007/BF0031748028312708
    [Google Scholar]
  49. RiosJ.L. WatermanP.G. A review of the pharmacology and toxicology of Astragalus. PTR1997116411418
    [Google Scholar]
  50. PistelliL. GiachiI. LeporiE. BertoliA. Further saponins and flavonoids from Astragalus verrucosus Moris.Pharm. Biol.200341856857210.1080/13880200390501370
    [Google Scholar]
  51. VerottaL. El-SebakhyN.A. Cycloartane and oleanane saponins from Astragalus sp.Studies in Natural Products Chemistry20012517923410.1016/S1572‑5995(01)80008‑9
    [Google Scholar]
  52. KrastevaI. BratkovV. BucarF. KunertO. KollroserM. Kondeva-BurdinaM. IonkovaI. Flavoalkaloids and flavonoids from Astragalus monspessulanus. J. Nat. Prod.201578112565257110.1021/acs.jnatprod.5b0050226558405
    [Google Scholar]
  53. ShahrajabianM.H. SunW. ChengQ. Astragalus, an ancient medicinal root in traditional Chinese medicine, a gift from silkroad.IJOABS20193062738
    [Google Scholar]
  54. Bouarab ChibaneL. DegraeveP. FerhoutH. BouajilaJ. OulahalN. Plant antimicrobial polyphenols as potential natural food preservatives.J. Sci. Food Agric.20199941457147410.1002/jsfa.935730206947
    [Google Scholar]
  55. AwadA.M. KumarP. Ismail-FitryM.R. JusohS. Ab AzizM.F. SaziliA.Q. Overview of plant extracts as natural preservatives in meat.J. Food Process. Preserv.2022468e1679610.1111/jfpp.16796
    [Google Scholar]
  56. Efenberger-SzmechtykM. NowakA. CzyzowskaA. Plant extracts rich in polyphenols: Antibacterial agents and natural preservatives for meat and meat products.Crit. Rev. Food Sci. Nutr.202161114917810.1080/10408398.2020.172206032043360
    [Google Scholar]
  57. ErkanN. DoğruyolH. GünlüA. Gençİ.Y. Use of natural preservatives in seafood: Plant extracts, edible film and coating.Food and Health2015113349
    [Google Scholar]
  58. ShanB. CaiY.Z. BrooksJ.D. CorkeH. Potential application of spice and herb extracts as natural preservatives in cheese.J. Med. Food201114328429010.1089/jmf.2010.000921142945
    [Google Scholar]
  59. KerdudoA. BurgerP. MerckF. DingasA. RollandY. MichelT. FernandezX. Development of a natural ingredient – Natural preservative: A case study.C. R. Chim.20161991077108910.1016/j.crci.2016.06.004
    [Google Scholar]
  60. DaneshniyaM. MalekiM.H. MohammadiM.A. AhangarianK. KondeskalaeiV.J. AlaviH. Antioxidant and antimicrobial activity of Ferula species’ essential oils and plant extracts and their application as the natural food preservatives.South Asian Res. J. Nat. Prod.202143123
    [Google Scholar]
  61. SundarS. PadmalathaK. HelasriG. VasanthiM. NarmadaB.S. LekhyaB. JyothiR.N. SravaniT. Anti-microbial activity of aqueous extract of natural preservatives-cumin, cinnamon, coriander and mint.Res J Pharm Technol20169784384710.5958/0974‑360X.2016.00159.1
    [Google Scholar]
  62. da SilvaB.D. BernardesP.C. PinheiroP.F. FantuzziE. RobertoC.D. Chemical composition, extraction sources and action mechanisms of essential oils: Natural preservative and limitations of use in meat products.Meat Sci.202117610846310.1016/j.meatsci.2021.10846333640647
    [Google Scholar]
  63. OfosuF.K. DaliriE.B.M. ElahiF. ChelliahR. LeeB.H. OhD.H. New insights on the use of polyphenols as natural preservatives and their emerging safety concerns.Front. Sustain. Food Syst.2020452581010.3389/fsufs.2020.525810
    [Google Scholar]
  64. TayelA.A. AlmabadyN.A. SorourN.M. DiabA.M. Application of natural plant extracts as colorants, preservatives, and anti‐listerial agents in processed fish products.J. Food Saf.2018382e1243510.1111/jfs.12435
    [Google Scholar]
  65. OstroskyE.A. MarcondesE.M.C. NishikawaS.O. LopesP.S. VarcaG.H.C. PintoT.J.A. ConsiglieriT.V.O. BabyA.R. VelascoM.V.R. KanekoT.M. Rubus rosaefolius extract as a natural preservative candidate in topical formulations.AAPS PharmSciTech201112273273710.1208/s12249‑011‑9635‑921643865
    [Google Scholar]
  66. SerraA.T. MatiasA.A. NunesA.V.M. LeitãoM.C. BritoD. BronzeR. SilvaS. PiresA. CrespoM.T. San RomãoM.V. DuarteC.M. In vitro evaluation of olive- and grape-based natural extracts as potential preservatives for food.Innov. Food Sci. Emerg. Technol.20089331131910.1016/j.ifset.2007.07.011
    [Google Scholar]
  67. HamadG.M. DarwishA.M. Abu-SerieM.M. El SohaimyS.A. Antimicrobial, antioxidant and anti-inflammatory characteristics of combination (Cassia fistula and Ocimum basilicum) extract as natural preservative to control & prevent food contamination.J. Food Nutr. Res.201751077178010.12691/jfnr‑5‑10‑8
    [Google Scholar]
  68. SelahvarziA. RamezanY. SanjabiM.R. MirsaeedghaziH. AzarikiaF. AbediniaA. Investigation of antimicrobial activity of orange and pomegranate peels extracts and their use as a natural preservative in a functional beverage.J. Food Meas. Charact.20211565683569410.1007/s11694‑021‑01141‑z
    [Google Scholar]
  69. GokogluN. Novel natural food preservatives and applications in seafood preservation: A review.J. Sci. Food Agric.20199952068207710.1002/jsfa.941630318589
    [Google Scholar]
  70. HartC. IlankoP. SirdaartaJ. RayanP. McDonnellP.A. CockI.E. Tasmannia stipitata as a functional food/natural preservative: Antimicrobial activity and toxicity. Phcog. Commn2014443347
    [Google Scholar]
  71. NegiP.S. Plant extracts for the control of bacterial growth: Efficacy, stability and safety issues for food application.Int. J. Food Microbiol.2012156171710.1016/j.ijfoodmicro.2012.03.00622459761
    [Google Scholar]
/content/journals/cbc/10.2174/0115734072310658240822045329
Loading
/content/journals/cbc/10.2174/0115734072310658240822045329
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test