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2000
Volume 21, Issue 6
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Introduction

Hepatocellular carcinoma (HCC) poses a threat to human health due to several risk factors associated with one’s lifestyle, including liver cirrhosis, alcohol intake, obesity, exposure to aflatoxin, hepatitis B and/or C virus infection, non-alcoholic steatohepatitis (NASH), diabetes and many other factors. The treatment of HCC involves several distinct approaches, including significant advancement in surgical interventions. Given the toxicity of conventional medicines or the need for a suitable approach focusing on the stages of HCC progression, the current treatment is not very effective, which brings a significant focus on improving alternative-targeted approaches as anti-HCC moieties.

Objective

Therefore, this review provides an update on how the phytoconstituents exhibit their anti-HCC effect by intervening in the control of autophagy.

Methods

This study conducted a thorough literature search on hepatocellular carcinoma (HCC), autophagy, and phytoconstituents. The search was performed using multiple search engines and the main keywords, and only English publications published before April 2023 were included.

Results

One of the various molecular-mediated mechanisms used in cancer therapies is ‘ a metabolic process whereby cellular stress causes damaged cells to be cleared out to preserve cellular homeostasis and provide cells with the nutrients they need to survive. Because of its dual activity as a tumor suppressor or tumorigenesis, autophagy-mediated manipulation could be a promising option for treating cancer.

Conclusion

Phytochemicals derived from natural sources offer an antitumorigenic effect and reduce the probability of HCC by regulating autophagy-mediated mechanisms and functioning as tumor suppressors.

© 2025 Bentham Science Publishers
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Phytochemicals as Autophagy Modulators in Hepatocellular Carcinoma
Curr. Bioact. Compd. 21, e250624231306 (2025); https://doi.org/10.2174/0115734072301308240607064104
/content/journals/cbc/10.2174/0115734072301308240607064104
/content/journals/cbc/10.2174/0115734072301308240607064104
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  • Article Type:     Review Article
Keyword(s): autophagy; Hepatocellular carcinoma; liver cancer; natural products; phytoconstituents; tumor suppressor

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