Recent Advances in Food Nutrition & Agriculture - Volume 17, Issue 1, 2026
Volume 17, Issue 1, 2026
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Recent Trends on Plants and Agricultural Products as Nutritional Source in Treating Diabetes
More LessAuthors: Suryakant Verma and Milind Sharad PandeA metabolic disease that requires insulin and is marked by consistently high blood sugar levels is known as diabetes mellitus. Many healthcare systems throughout the world have long relied on medicinal herbs as a means of addressing diabetes and its complications. Traditional medicine derived from plant extracts has several advantages over contemporary pharmaceuticals, including lower costs, greater clinical efficacy, and fewer side effects. Primarily, the condition has been managed by a range of synthetic medications that improve the altered glycemic state in individuals with diabetes. Synthetic medications work well, but along with their benefits, they come with noticeable adverse effects. Due to the lack of knowledge regarding their chemical composition, preparation method, active bio-actives, potential side effects, and the optimal way to administer them, medicinal plants have not been fully utilised as acceptable drugs in the treatment of diabetes, despite their long history of use as primary health care. Because of a lack of sufficient data on the parameters described earlier, most medicinal plants that show promise as anti-diabetic agents do not make it to the clinical trial phase. Medicinal plants that have been studied in humans with diabetes and shown promise as a treatment for the disease, either alone or in conjunction with other plants, are summarised in this review. Pharmacologically active phytomolecules with an antidiabetic action that are derived from medicinal plants were the primary topic of this review article. Its goal was to discuss their importance in diabetes management and therapy. These all-natural substances have the potential to be successful and alternative diabetes treatments, as well as a new method of approaching the disease.
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Redefining Chronic Disease Care: Unleashing the Potential of Phytomedicines
More LessAuthors: Tohfa Siddiqui, Vikram Sharma, Sakshi Kumar and Komal GuptaPhytomedicines represent a diverse array of plant-derived compounds renowned for their therapeutic potential. Traditionally, these mixtures were extracted using water or ethanol, but simpler methods like tea infusions are gaining prominence. However, ensuring the efficacy and safety of phytomedicines demands high-quality plant material and stringent production processes. Advancements in biological screening techniques have shed light on the mechanisms of action of phytomedicines, emphasizing the significance of synergistic interactions among their constituents. Ten widely-used phytomedicines are outlined, detailing their applications, efficacy, and safety profiles, underscoring their global importance in healthcare. Moreover, ongoing research in phytomedicine development showcases the rich biodiversity's capacity to yield novel medicinal compounds. These studies highlight the potential of untapped plant sources in providing innovative solutions to medical challenges, offering promising avenues for future therapeutics. In essence, the utilization of phytomedicines underscores a fusion of traditional knowledge with modern scientific approaches, emphasizing both the importance of respecting ancient remedies and harnessing contemporary advancements for improved healthcare outcomes.
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Therapeutic Potential of Quercetin Analogues: Prospective and Advances
More LessAuthors: Harsh Yadav, Rishabha Malviya, Niranjan Kaushik and Sathvik Belagodu SridharThe purpose of the article is to investigate the therapeutic potential of quercetin and related compounds by elucidating their pharmacological characteristics and molecular mechanisms of action. The potential benefits of quercetin and its analogs for cardiovascular health, disorders of the brain, metabolic disorders, and more are discussed in the discussion part of this article. Concerns about their clinical efficacy due to issues with bioavailability and distribution are also discussed. This section of the paper emphasizes the importance of researchers and clinicians working together to maximize the incorporation of these chemicals into real-world therapeutic approaches. In conclusion, quercetin, along with related substances, shows great potential in a wide range of therapeutic settings. Potentially useful for the management of a wide variety of illnesses, their multiple methods of action include the regulation of pathways for cell signaling and interaction with different enzymes. However, additional clinical trials are needed to verify their efficacy and safety.
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Functionality of Semolina Pasta Supplemented with Grapefruit Flavedo Byproduct: Effect on Phytochemical, Functional, Textural, Cooking, and Sensorial Quality
More LessAuthors: Sahil Chaudhary, Barinderjit Singh, Tanjeet Singh Chahal and Yashi SrivastavaBackgroundPasta is consumed worldwide and can be an excellent food matrix for supplementation. Grapefruit (Citrus paradisi) flavedo byproduct is reported to contain considerable amounts of bioactive compounds, which represent a valuable and sustainable source of phenolics. So far, there is limited information available about the utilization of grapefruit flavedo byproducts for supplementation of pasta.
MethodsThe present study aimed to investigate the effect of freeze-dried grapefruit flavedo powder (GFP) incorporation at various concentrations (3, 6, 9, and 12%) on the phytochemical, functional, textural, microstructural, and sensory quality of the developed pasta.
ResultsFortification with GFP significantly (P<0.05) enhanced antioxidant activities relative to DPPH and FRAP and increased the total phenolic and flavonoid content from 132.41–211.63 mg GAE/100 g and 73.20–96.83 mg QE/100 g, respectively. Supplementation with GFP significantly (P<0.05) reduced the optimum cooking time of pasta, while cooking loss increased up to 6.32% with 12% GFP incorporation, which was still under the acceptable limits (<8%). The addition of GFP decreased the L* value, while the a* and b* values increased for the pasta. SEM analysis presented that GFP incorporation in pasta affected the structural integrity attributable to the enhanced fiber levels, inducing a weaker matrix, as ascertained by textural profile analysis (TPA) with a decline in hardness attribute with increasing GFP concentration. Sensory analysis divulged overall acceptability scores of 8.4 for the pasta with 6% GFP, while further increments in GFP levels led to decreased sensory scores.
ConclusionGrapefruit peels are typically discarded as waste, the outer layer of which, i.e., flavedo, could be used to enrich pasta. The present research divulged that pasta supplementation with freeze-dried flavedo powder could provide total phenolic content, flavonoid content, and antioxidant potential without compromising on the technological and sensory quality of pasta. Utilization of this citrus waste as a bioactive food ingredient with promising effects represents a valuable byproduct valorization strategy.
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Production and Characterization of Pomelo Albedo Powder Based Pasta: Physicochemical, Functional, Textural and Sensorial Attributes
More LessAuthors: Simple Sharma, Barinderjit Singh and Yashi SrivastavaBackgroundPomelo albedo peel byproducts are composed of many health-beneficial phytochemicals during processing. This study aimed to maximize the potential of incorporating pomelo albedo powder as a bioactive ingredient in pasta.
MethodsIn the present study, pomelo albedo was fortified with pasta at five different concentrations (0, 3, 6, 9, and 12%), and its effects on the antioxidant, functional, textural, and sensorial attributes of pasta were investigated.
ResultsThe results showed that the incorporation of albedo powder remarkably elevated the antioxidant properties and significantly increased the WAC (121.23 to 188.97%) and OAC (110.15 to 136.55%). An increase in pomelo albedo is associated with a decrease in cooking time from 10.24 to 8.28 min with cooking loss that is within an acceptable range. The pomelo albedo formulation improved the color and sensorial attributes. A higher albedo concentration significantly reduced the breaking stress, fracturability, firmness, and hardness but increased the adhesiveness and cohesiveness of pasta. FTIR spectra revealed the presence of characteristic peaks, and SEM reflects pomelo albedo's impact on the structural integrity of the pasta.
ConclusionOn the basis of physicochemical, cooking, and sensory data, pasta with a 6% pomelo albedo formulation was found to be the most acceptable, with an overall acceptability of 8.51. Thus, pomelo albedo can be incorporated into the industry for the preparation of pasta with enhanced nutritional characteristics.
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Biochar Amendment Alleviates the Risk of High-Salinity Saltwater Intrusion for the Growth and Yield of Rice (Oryza sativa L.)
More LessIntroductionSaltwater intrusion poses a serious risk to global food security. As a soil amendment, biochar mitigates the negative effects of saltwater intrusion in rice, yet the beneficial effects on agricultural productivity with different exposure times and salt concentrations have not been fully examined.
MethodsA pot experiment was conducted to investigate the effects of 30% (w/w) rice husk biochar on the growth, ion accumulation, and yield of the Phitsanulok 2 rice cultivar under salt stress due to saltwater intrusion. Rice plants were grown in saline soil amended with biochar and were salinized with 6, 8, and 10 dS/m saltwater for 1, 2, and 3 months. A treatment without biochar was taken as the control.
ResultsThe results showed that biochar amendment significantly increased the survival, shoot height, and tiller numbers of rice treated with the 6-10 dS/m saltwater for 1 and 2 months, as well as the treatment with 6 dS/m salt water for 3 months, in comparison with the control. The grain yield was about 40 g/pot for rice with biochar treated for 1 month with 6-10 dS/m saltwater and for the rice treated for 2 months with 6 dS/m. The results indicated that biochar application could alleviate the intrusion of high-salinity water for 1 month of salt exposure, and it could alleviate the intrusion of medium-salinity water for 2 months.
ConclusionTherefore, a 30% (w/w) rice husk biochar amendment is a reliable strategy for mitigating the risks of saltwater intrusion for the growth and productivity of rice.
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Pharmacognostic, GC-MS, and In silico Molecular Docking Studies of Phytoconstituents from Urtica dioica and Zanthoxylum armatum for Male Antifertility Potential
More LessAuthors: Swati Wadhawan, Anurag Chaudhary and Sameksha KoulBackgroundResearch on non-hormonal alternatives to traditional methods of male contraception has been prompted by the growing world population as well as the need for effective and reversible treatments. This study aimed to examine the possible antifertility potential of two medicinal herbs, i.e., Urtica dioica and Zanthoxylum armatum, that have been utilized for centuries in different cultures.
MethodologyA thorough pharmacognostical analysis was carried out to identify the ingredients of these plants. The phytoconstituents from Urtica dioica aqueous 96% methanolic leaf extract and Zanthoxylum armatum fruit essential oil were subjected to in silico molecular docking screening. The phytoconstituents were profiled using GC-MS analysis. To investigate how these phytoconstituents interact with important proteins involved in male fertility and identify potential candidates for the development of a plant-based oral contraceptive for men, further in silico molecular docking (receptor protein ID of 7FIH (3.20 Å), 7BPR (1.95 Å), and 2Q7J (1.90 Å) experiments were carried out.
ResultsThe GC-MS analysis revealed a wide variety of bioactive chemicals. Promising interactions between the discovered phytoconstituents and specific protein targets were found by the in silico molecular docking investigation, indicating the possibility of antifertility effects.
ConclusionThe results of this study demonstrate the medicinal use of these plants and provide the basis for the development of novel male contraceptive medicines and their further experimental validation.
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Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health
Authors: Romy Roy, Shamsudheen Marakkar, Munawar P. Vayalil, Alisha Shahanaz, Athira Panicker Anil, Shameer Kunnathpeedikayil, Ishaan Rawal, Kavya Shetty, Zahrah Shameer, Saraswathi Sathees, Adarsh Pooradan Prasannakumar, Oommen Kaleeckal Mathew, Lakshminarayanan Subramanian, Khader Shameer and Kamlesh K. Yadav
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