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Abstract

Introduction

In clinical practice, several commercial drug-eluting stent products have limitations during the early drug-release phase due to the phenomenon of initial burst release (IBR), which may increase the risk of restenosis. This experimental study utilized a multilayer strategy with genipin-crosslinked chitosan as the polymer and curcumin as the drug to address these limitations.

Methods

Based on the forward speed of the rotary drive (7, 8, and 9 mm/s), ultrasonic coating was used to create uniform layers, followed by scanning electron microscopy (SEM) and a release study. Validation of the analytical method confirmed the reliability of the UV-Vis spectrophotometric technique.

Results

The release data modeled with the Korsmeyer-Peppas model show Super Case II transport relaxation/erosion. The Peppas-Sahlin model indicates that Fickian diffusion dominated the first 6–7 days, after which polymer relaxation became dominant. At 9 mm/s, Fickian diffusion persisted for up to seven days, whereas at 7 and 8 mm/s, it was limited to the first six days.

Discussion

The multilayer system maintains matrix integrity during drug release, preventing initial burst release. Once the mechanism shifts from diffusion to relaxation, no burst is observed. The zero-order model fit confirms that the design reflects a controlled-release profile.

Conclusion

The strategy demonstrates controlled release without initial burst.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2026-01-21
2026-02-26

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Controlled Release Ultrasonic-Coated Drug-Eluting Stent with Multilayers of Chitosan and Curcumin
Bentham Science Publishers ; https://doi.org/10.2174/0126673878409943251202182512
/content/journals/raddf/10.2174/0126673878409943251202182512
/content/journals/raddf/10.2174/0126673878409943251202182512
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  • Article Type:     Research Article
Keywords: release kinetic ; burst release ; drug-eluting stent ; multi-layers ; ultrasonic coating ; Controlled release

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