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2000
Volume 19, Issue 1
  • ISSN: 2667-3878
  • E-ISSN: 2667-3886

Abstract

The Blood-Brain Barrier (BBB) makes it extremely difficult to get drugs to the brain, yet highly branching macromolecules known as dendrimers show a lot of promise in this regard. This review delves into the current and future prospects of dendrimers in facilitating brain-specific drug delivery within the framework of cerebroanoreach. The unique structural features of dendrimers allow for precise regulation of surface function, size, and shape, which are critical for targeting specific cell types in the brain and increasing blood-brain barrier permeability. Second, they can be conjugated with imaging agents, peptides, or pharmaceuticals thanks to their versatile surface chemistry, which enhances diagnostic capabilities and treatment efficacy. Recent advances in nanoformulations based on dendrimers have demonstrated promising improvements in the solubility, stability, and bioavailability of medications, suggesting their possible use in therapeutic contexts. Various obstacles, such as toxicity profiles and production bottlenecks that require scaling up are also addressed, with a focus on ongoing research projects and potential remedies. One potential solution to the problems with cerebroanoreach is the use of dendrimers for brain-specific drug delivery; this could revolutionize the treatment of neurological diseases and the precision of neurology diagnostics. By synthesizing current knowledge and future directions, this review urges the continuance of interdisciplinary collaboration, which is crucial for fully realizing the potential of dendrimers in neuroscience and therapeutic innovation.

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/content/journals/raddf/10.2174/0126673878303735240906065735
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Unlocking Dendrimers Future Potential for Brain-Specific Drug Delivery in Cerebroanoreach
Recent Advances in Drug Delivery and Formulation 19, 16 (2025); https://doi.org/10.2174/0126673878303735240906065735
/content/journals/raddf/10.2174/0126673878303735240906065735
/content/journals/raddf/10.2174/0126673878303735240906065735
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  • Article Type:     Review Article
Keyword(s): blood-brain barrier; Dendrimer; invasive; noninvasive; PAMAN; polypropyleneimine

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