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Lotus leaves are the main medicinal parts of Nelumbo nucifera Gaertn, which is widely distributed in East Asia, especially in China. It contains a variety of chemical activation components. Among them, alkaloids are considered to be the most relevant ingredient for its bioactivity. This article mainly introduces the structure of alkaloids isolated from Lotus leaves and their pharmacological activities, such as anti-obesity, antioxidant, antiviral, anticancer, anti-diabetic activities.