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2000
Volume 16, Issue 1
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Introduction

Combining multiple natural extracts may provide an additive and/or synergistic effect, increasing the anti-cancer potential of the formulation while aiding in the search for targeted chemical compounds for cancer treatment.

Methods

Here, we confirmed the individual anti-proliferation effect of bee venom (BV) and red algae polysaccharide extract (PE) on HCT-116 and HT-29 colon cancer cell lines and explored the synergistic effect of these two natural extracts, aiming to develop a new mixture with promising potential against colorectal cancer.

Results and Discussion

Given that the synergy between BV and algal PE was evaluated using concentrations of 5 and 250 μg/mL, respectively, a significant combined effect was noted, leading to at least a 20% more reduction in cell viability than with either extract alone. Additionally, the combination therapy significantly reduced cell migration more than either extract achieved on its own, exhibiting increased anti-migratory capability in a time-dependent manner.

Conclusion

This synergy indicates the potential of enhanced anti-cancer efficacy in formulations based on combinations of natural components.

© 2026 Bentham Science Publishers
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2025-03-12
2025-10-22

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Synergistic Cytotoxic Effect of Apis Mellifera syriaca Venom and Jania rubens Polysaccharide Extract on HCT-116 and HT-29 Colon Cancer Cell Lines
Natural Products Journal, The 16, E22103155359674 (2026); https://doi.org/10.2174/0122103155359674250306055130
/content/journals/npj/10.2174/0122103155359674250306055130
/content/journals/npj/10.2174/0122103155359674250306055130
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  • Article Type:     Research Article
Keyword(s): algal extract; Anti-cancer activity; Apis mellifera; bee venom; biomolecules; colorectal cancer; Jania rubens

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