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2000
Volume 15, Issue 9
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

Lam. is one of the very few lign-aloes trees that can produce highly valuable resin-impregnated heartwood, commonly known as agarwood.

Aim

This study aimed to determine the chemical profile of essential oil and describe its antiproliferative effects against the HeLa cervical cancer cell line.

Method

The essential oils hydro-distilled from agarwood were characterised using GC−MS with the aid of spectral deconvolution. The antiproliferative effects were evaluated the MTT assay.

Result

A total of 143 metabolites were tentatively identified in two different grades of essential oils, which accounted for 56.80% and 78.19% of the total ion counts, respectively. These metabolites were distributed over the chemical families of monoterpenes, sesquiterpenes, cyclic hydrocarbons, and others. The essential oils exhibited antiproliferative activities, with IC values of 79.42 and 128.77 µg/mL, respectively.

Conclusion

The results have suggested the chemical differences in secondary compounds to be the main factor contributing to the decrease in cell viability. Further investigations are warranted to understand its mechanisms of action and its potential use in cervical cancer treatment.

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Phytochemical Profiling of Aquilaria malaccensis Lam. Essential Oils and their Antiproliferative Potential against HeLa Human Cervical Cancer Cells
Natural Products Journal, The 15, E22103155319796 (2025); https://doi.org/10.2174/0122103155319796240909075317
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  • Article Type:     Research Article
Keyword(s): agarwood; antiproliferative activity; Aquilaria malaccensis Lam.; gas chromatography; HeLa cells; mass spectrometry; MTT assay; spectral deconvolution

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