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2000
Volume 15, Issue 8
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

HIV/AIDS is one of the most widespread global diseases. It is caused by the human immunodeficiency virus (HIV), which leads to the development of acquired immunodeficiency syndrome (AIDS). In AIDS patients, the immune system progressively weakens, making them vulnerable to various infections and cancers. The virus can be transmitted through the exchange of bodily fluids such as blood, semen, vaginal fluid, and breast milk, where HIV can be found in both free virus particles and infected immune cells. Although drug resistance remains a challenge for HIV/AIDS treatment, researchers are exploring the use of natural substances in the development of anti-HIV drugs. Clinical trials based on plant-derived compounds are currently being conducted. Experimental research suggests that plants may have the potential to treat HIV. However, the identification of active compounds, testing of extracts, and creation of suitable bioassays are all complex processes. Natural product scientists face the challenge of separating these complicated extracts into their active components. Various phytochemicals found in Astragalus membranaceus Bunge, L, Combretum molle (R. Br. ex. G. Don.) Engl& Diels, (L.) Greuter, Helichrysum populifolium, (Masson) Sweet ex Decne, and Hypericumperf, have been investigated pharmacologically and pharmacokinetically. Further research is needed to optimize formulations and production in accordance with preclinical safety and efficacy studies.

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/content/journals/npj/10.2174/0122103155300377240831120327
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A Review of the Therapeutical Perspective of Phytochemicals in the Treatment of HIV
Natural Products Journal, The 15, e22103155300377 (2025); https://doi.org/10.2174/0122103155300377240831120327
/content/journals/npj/10.2174/0122103155300377240831120327
/content/journals/npj/10.2174/0122103155300377240831120327
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  • Article Type:     Review Article
Keyword(s): AIDS; HIV; mechanism; pharmacophore; phytochemicals; potency

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