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2000
Volume 15, Issue 8
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

Myocardial Ischemia-Reperfusion Injury (MIRI) is associated with adverse cardiovascular outcomes that lead to the death of ischemic cardiomyocytes and, finally, dysfunction of cardiac tissue.

Objectives

This systematic review aims to comprehensively investigate and systematically review the existing literature on the effects of soy isoflavones and their underlying mechanisms in mitigating MIRI injuries.

Methods

A systematic search was conducted in high-coverage scientific databases, including Web of Science, MEDLINE/PubMed, Scopus, Embase, and Cochrane Library. On 6th December, 2023, an extensive literature search was done using predefined search terms (According to MeSH terms) and inclusion criteria. Any studies that investigated the effects of soy isoflavones on MIRI injuries were included. Search strategy, screening of the publications, and data extraction were performed following PRISMA guidelines 2020.

Results

Diverse mechanisms underlying the cardioprotective effects of soy isoflavones against MIRI include antioxidant properties, anti-inflammatory effects, enhanced mitochondrial function, regulation of apoptosis pathways, improving angiogenesis effects, attenuating heart histological changes, modulating factors that affect hemodynamic changes, and reducing Ca+2 overload. Although most studies reported promising effects in reducing the complications of MIRI, a small number of studies also showed no significant effect in this regard. Also, they did not report any specific side effects from consuming isoflavones alone.

Conclusion

The findings suggest that soy isoflavones as a complementary therapeutic strategy potentially benefit MIRI outcomes and support their role in cardiovascular health. However, further well-designed clinical trials are warranted to validate these findings and establish their clinical significance in cardiovascular disease management.

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/content/journals/npj/10.2174/0122103155327054240822064326
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The Biological Effects of Soy Isoflavones against Myocardial Ischemia-reperfusion Injuries: A Systematic Review
Natural Products Journal, The 15, e22103155327054 (2025); https://doi.org/10.2174/0122103155327054240822064326
/content/journals/npj/10.2174/0122103155327054240822064326
/content/journals/npj/10.2174/0122103155327054240822064326
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  • Article Type:     Review Article
Keyword(s): cardioprotection; daidzein; genistein; glycitein; myocardial ischemia-reperfusion injury; Soy isoflavones

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