Lipid-based Nanocarriers for mRNA Delivery: Vital Considerations and Applications

The use of mRNA in therapeutics has lately emerged as a powerful strategy for alleviating the various viral infections and diseased conditions, along with prophylaxis. However, a key challenge in their efficient delivery is the protection of the nucleic acid from degradation followed by mRNA transport to the cells. In this regard, clinical translation of mRNA therapeutics has largely been facilitated with the advent of lipid-based nanoparticles (LBNPs). LBNPs–mRNA vaccines currently being employed for COVID-19 is one such instance substantiating and endorsing the use of lipidic nanocarriers for mRNA therapeutics. Thus, the current review article aims to furnish information on developmental challenges, different aspects of lipid-based carrier systems for mRNA delivery, their vital applications in different diseases and the future potential of LBNPs in therapeutics.