Mini-Reviews in Organic Chemistry - Volume 13, Issue 2, 2016

The fruit of Cnidium monnieri (L) Cusson is an important traditional medicine employed in Taiwan and China as the treatments of impotence, sterilization, renal disease, dermatosis, colpitis, inflammation and gynecological disease. Peroxisome Proliferator-activated Receptor γ (PPARγ) and Farnesoid X receptor (FXR) are the members of nuclear receptor superfamily that have been targeted for developing treatments for chr Read More

Nuclear receptors (NRs) are ligand-activated transcription factors modulating significant biological functions including cell growth, lipid metabolism, and glucose homeostasis, so they are frequently to be utilized as important drug targets to develop therapeutic reagents. Farnesoid X receptor (FXR) with bile acids as the natural ligands, plays an essential role in regulation of bile acid and glucose metabolism, and is involved in th Read More

Cationic polyacrylamide (CPAM) is a polyelectrolyte whose monomeric unit contains ionizable cationic groups. In recent years, CPAM has received increasing attention owing to its unique properties and superior performance compared with those of other conventional inorganic coagulants and organic polymeric flocculants. This review examined the recent advances in CPAM synthesis. The synthetic mechanisms include direct c Read More

Magnetic polymer microspheres with unique magnetic properties and excellent physical chemical properties, such as strong stability, high biocompatibility, and exclusive adsorption properties, are widely used in biology and medicine, as well as show unique advantages in environmental fields. This article aims to provide recent preparation and characterization methods of magnetic polymer microspheres and their applic Read More

Natural products bearing a triazaspirocyclic motif have received significant attention in recent years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles in Nature, their biological acti Read More

β-Aminocarbonyl compounds are useful building blocks for the synthesis of biologically and medicinally important molecules. They are important intermediates for molecules like β-amino alcohols, β-amino acids and lactams which have applications in various pharmaceutical and natural product syntheses. The derivatives of β-aminocarbonyl compounds have found applications as diverse therapeutic agents such as antim Read More

Chitosan is an ideal biomaterial due to its excellent comprehensive properties. Cyclodextrins bearing the cavity structure and amphiphilic properties have become the focus of supramolecular chemistry. The chemical immobilization of cyclodextrin on the chitosan skeleton can be a feasible means to generate supramolecular host material. However, cyclodextrin is usually immobilized on the 2-NH2 group of chitosan, which suppress Read More