Phenothiazine Derivatives as Potential Antiproliferative Agents: A Mini- Review

Abstract: Research for discovering chemical entities with antiproliferative properties to combat globally rising cancer cases has witnessed tremendous interest in recent years. Phenothiazines possess novel antiproliferative potentials and have often be described as crucial sources of scaffolds for anticancer drug discovery. Some several phenothiazine-hybrid compounds recently synthesised are effective against various cancer cell lines with improved multidrug resistance. In synthesising these phenothiazine-derivatives, therapeutic potentials of the phenothiazines are exploited, and they are enriched by molecular hybridisation with moieties known to possess great pharmacological profiles. This article critically reviews the anticancer properties of phenothiazine derivatives and focuses on the possibility of the derivation of the leads for a further spectrum of antiproliferative activities.